Antibodies to extracellular matrix proteins in the sera of MRL-lpr mice

Ratkay, Leslie G.; Tonzetich, J.; Waterfield, J D

doi:10.1016/0090-1229(91)90021-2

Cited by 16 publications

(23 citation statements)

References 21 publications

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“…As 60 ppb-0.6 ppm of sulfide were demonstrated in the culture medium utilized for experiments that examined the adverse effects of VSCs on human cell cultures, these studies, which were discussed in this paper, could simulate of the conditions of human tissues [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Total VSCs or H 2 S concentration in mouth air from healthy subjects is reported as a maximum of 2 ppm or 1 ppm, while several times this concentration is found in periodontal patients [4,33,34].…”

Section: Toxicity Of Vscs In General Conditionsmentioning

confidence: 99%

“…The host factors of periodontitis are clearly identified, but the etiology of periodontitis has not yet been explicitly illustrated, especially at its initial stage [7]. It has been recently elucidated that VSCs reduce the effectiveness of the gingival epithelial tissues that normally play a key role as a barrier against penetration and invasion by detrimental compounds and microorganisms [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Oral malodorous compounds are periodontally pathogenic and carcinogenic

Yaegaki

2008

Japanese Dental Science Review

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Section: Toxicity Of Vscs In General Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral malodorous compounds are periodontally pathogenic and carcinogenic

Yaegaki

2008

Japanese Dental Science Review

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“…The mode by which nephrophilic antibodies bind glomeruli still remains uncertain. Some studies lend support for direct antibody cross-reactivity with glomerular basement membrane components, including collagen, laminin, and heparan sulfate, very often with pathogenic consequences (27,(44)(45)(46)(47)(48)(49). As gauged by ELISA cross-reactivity and molecular sequence comparison, this class of autoantibodies appears to overlap ANAs (36).…”

Section: Figurementioning

confidence: 99%

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

et al. 1999

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Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of mice. Our previous work has shown that B6.NZMc1 mice, congenic for Sle1, exhibit loss of tolerance to chromatin but do not develop any pathogenic autoantibodies or disease. B6.NZMc7 mice, congenic for Sle3, exhibit low-grade polyclonal B-and T-cell activation, elevated CD4/CD8 ratios, and mildly penetrant glomerulonephritis. In contrast to these monocongenics, the present study reveals that B6.NZMc1|c7 mice, bicongenic for Sle1 and Sle3, exhibit splenomegaly, significantly expanded populations of activated B and CD4 + T cells, and a robust, variegated IgG autoantibody response targeting multiple components of chromatin (including double-stranded DNA), intact glomeruli, and basement membrane matrix antigens. As one might predict, these mice, particularly the females, exhibit highly penetrant glomerulonephritis.These findings lend strong support to a two-step epistatic model for the formation of pathogenic, nephrophilic autoantibodies in lupus. Whereas loci such as Sle1 may serve to breach tolerance to chromatin, full-blown pathogenic maturation of the autoantibody response appears to require additional input from other loci (such as Sle3) and gender-based factors.

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“…In lupus sera, reactivity against heparan sulphate proteoglycan, laminin, collagen type IV, fibronectin and entactin has been described [16]. In another experimental model for lupus nephritis, the chronic graft-versus-host (GVH) model, a role for anti-basement membrane and anti-tubular brush border antibodies has been proposed [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis; a longitudinal study on plasma and glomerular eluates in MRL/l mice

Bruggen¹,

Kramers²,

Hylkema

et al. 1996

Clinical and Experimental Immunology

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SUMMARYThe relationship between autoantibody reactivities and nephritis in systemic lupus erythematosus (SLE) is unclear. We studied MRL/l mice which developed a considerable albuminuria (either mice with short (< 1 week) or heavy and prolonged (3 weeks) albuminuria) and compared them with non-albuminuric age-matched controls, with young (12 weeks old) non-albuminuric mice and with mice which were followed for 36 weeks and did not develop albuminuria. In a longitudinal prospective study on plasma samples we correlated a variety of anti-nuclear reactivities and reactivities against extracellular matrix (ECM) components, with the onset of albuminuria. We found that at the onset of albuminuria, anti-DNA was higher while anti-nucleosome and anti-H2A/H2B-DNA subnucleosome reactivities were lower compared with age-matched non-albuminuric mice. We also studied glomerular eluates of these mice in ELISA and in indirect immunofluorescence (IF). In the eluates we found with IF that anti-glomerular basement membrane (GBM)-tubular basement membrane (TBM) antibodies were already present in 12-week-old non-albuminuric mice. These eluates showed no anti-nuclear antibodies. In eluates of albuminuric mice more immunoglobulin was deposited, and anti-ECM, anti-DNA and anti-nucleosome reactivities were higher than in eluates of age-matched non-albuminuric mice. The deposition of antinucleosome antibodies preceded the deposition of anti-DNA antibodies since they were deposited to a greater extent in mice with a short albuminuria. We conclude that anti-GBM-TBM antibodies are the first autoantibodies that deposit in glomeruli of MRL/l mice at an early age. The onset of albuminuria is associated with additional deposition of both anti-ECM and anti-nuclear (anti-nucleosome and anti-DNA) antibodies, but the difference with non-albuminuric mice seems to be more quantitative than qualitative.

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Antibodies to extracellular matrix proteins in the sera of MRL-lpr mice

Cited by 16 publications

References 21 publications

Oral malodorous compounds are periodontally pathogenic and carcinogenic

Oral malodorous compounds are periodontally pathogenic and carcinogenic

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies

Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis; a longitudinal study on plasma and glomerular eluates in MRL/l mice

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