Antibodies to HBV surface antigen in relation to interferon-λ3 in hemodialysis patients

Grzegorzewska, Alicja E.; Świderska, Monika; Mostowska, Adrianna; Warchoł, Wojciech; Jagodzińśki, Paweł P.

doi:10.1016/j.vaccine.2016.08.073

Cited by 7 publications

(15 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…rs12979860 and rs8099917 IFNL3 SNPs were involved in the production of IFN-λ3 [33]. IFNL3 rs8099917 polymorphisms seem to be associated with IFN-λ3 plasma levels also in HD subjects [34]. Major alleles of rs12979860 and rs8099917 have been found to influence the response of HCV-infected patients to pegylated-IFN/ribavirin therapy [35].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The G allele in IFNL3 rs8099917 was attributed to lower circulating IFN-λ3 than that shown in the TT genotype subjects [34]. Circulating IFN-λ3 strongly correlates with anti-HBs production after HBV vaccination and infection in this group of patients [34]. However, a direct association between IFNL3 polymorphic variants and anti-HBs generation was not demonstrated [13], although both are related to survival of HD patients.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients – a prospective study

Grzegorzewska¹,

Świderska²,

Mostowska³

et al. 2017

BMC Nephrol

Self Cite

View full text Add to dashboard Cite

BackgroundCirculating pro-inflammatory cytokines were associated with increased relative mortality risk, while immune parameters reflecting improved T-cell function were predictors of survival in hemodialysis (HD) patients. We evaluated in the prospective study whether variants in T helper cell cytokine-associated genes are determinants of mortality in HD patients.MethodsThe study was carried out in 532 prevalent HD subjects who were followed-up for 7 years. HRM analysis was used for IFNL3, IL12A, IL13, and IL4R genotyping. CCL2, IL12B, and IL18 were genotyped using PCR–RFLP analysis. Survival analyses were conducted using the Kaplan-Meier method and the Cox proportional hazard model.ResultsIn univariate analyses, IFNL3 rs8099917 was associated with all-cause mortality in recessive model of inheritance (log-rank test P = 0.044), IL12A rs568408 - in dominant model (log-rank test P = 0.029). Minor homozygotes (the genotype GG) in IFNL3 rs8099917 showed shorter survival during the study (3.6, 1.0–7.0 years vs 4.7, 0.1–7.0 years, P = 0.009) than the major allele (T) bearers. The rs8099917 GG patients demonstrated higher risk of death than the remaining patients (GT + TT) (OR 1.94, 95%CI 1.11–3.40, P = 0.020). Major homozygosity (the genotype GG) in IL12A rs568408 was associated with higher mortality than that shown in bearers of the minor allele (AA + AG) (HR 1.31, 95%CI 1.02–1.69, P = 0.035). In multivariate analyses, however, the mentioned polymorphisms were not independent predictors of survival.ConclusionsPolymorphisms of IFNL3 rs8099917 and IL12A rs568408 contribute to survival of HD patients, but not as independent factors.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-017-0582-x) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients – a prospective study

Grzegorzewska¹,

Świderska²,

Mostowska³

et al. 2017

BMC Nephrol

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our earlier studies, HD individuals showing persistent HCV infection, subjects not developing anti -HBs after HBV infection or vaccination, or patients presenting combined HBsAg and HCV RNA positivity demonstrated lower circulating IFN -λ3 levels compared with patients who had favorable outcomes in terms of the above infections and with those never exposed to HB and HCV. 19,22 HD groups with favorable outcomes, as well as noninfected individuals, did not differ in circulating IFN -λ3 levels. 19 The currently studied HD patients with isolated HEV IgG positivity were considered as those with resolved HEV infection.…”

Section: Correlates Of Anti-hepatitis E Virus Immunoglobulin Gmentioning

confidence: 80%

“…Both single nucleotide variants (SNVs) were genotyped using high -resolution melting curve analysis as previously described. 22 For quality control, 20 of the randomly chosen samples were regenotyped using the same genotyping method; the concordance rate was 100%.…”

Section: Characteristics Of Patients Positive For Anti-hepati-mentioning

confidence: 99%

IFN-λ4 gene polymorphisms, circulating IFN-λ3, and clinical variables in hemodialysis patients exposed to hepatitis E virus

Grzegorzewska¹,

Świderska²,

Niepolski³

et al. 2018

Polish Archives of Internal Medicine

Self Cite

View full text Add to dashboard Cite

Introduction Factors associated with hepatitis E virus (HEV) infection are rarely recognized in patients on renal replacement therapy (RRT), and the results of studies are inconsistent. Objectives We aimed to search for determinants of HEV seroprevalence among polymorphisms of the interferon‑λ4 gene (IFNL4) associated with seroclearance of hepatotropic viruses (IFNL4 rs12979860, rs8099917 near IFNL4), circulating interferon λ3 (IFN‑λ3), and clinical variables of patients treated with hemodialysis (HD) in a HEV‑endemic region. Patients and methods The study was carried out in 90 HD patients. HEV open reading frame 2 antigen (HEV Ag), immunoglobulin M and G antibodies to HEV (anti‑HEV IgM and anti‑HEV IgG, respectively) and IFN‑λ3 were tested, and IFNL4 polymorphic variants (rs8099917, rs12979860) were genotyped. Survival analysis was conducted concerning anti‑HEV IgG positivity. Results In the study group, there were 37.8% anti‑HEV IgG‑positive subjects. None was HEV Ag or anti‑HEV IgM positive. HD modalities utilizing high‑flux dialyzers (adjusted odds ratio [OR], 3.586; 95% confidence interval [CI], 1.142-11.263; P = 0.03) as well as major homozygosity in rs8099917 (adjusted OR, 4.933; 95% CI, 1.516-16.054; P = 0.008) and rs12979860 (adjusted OR, 3.537; 95% CI, 1.136-11.014, P = 0.03), but not circulating IFN‑λ3 levels, were positive determinants of anti‑HEV IgG positivity. Liver enzyme activities and C‑reactive protein levels tested as response variables to HEV exposure, as well as survival probability, were not different between patients stratified by anti‑HEV IgG positivity. Conclusions Among HD patients, IFNL4 polymorphisms and treatment with high‑flux HD are explanatory variables for isolated anti‑HEV IgG positivity indicating spontaneous HEV resolution.

show abstract

Circulating interferon-λ3 and post-vaccination antibodies against the surface antigen of hepatitis B virus in hemodialysis patients exposed to hepatitis E virus

et al. 2019

View full text Add to dashboard Cite

Antibodies to HBV surface antigen in relation to interferon-λ3 in hemodialysis patients

Cited by 7 publications

References 51 publications

Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients – a prospective study

Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients – a prospective study

IFN-λ4 gene polymorphisms, circulating IFN-λ3, and clinical variables in hemodialysis patients exposed to hepatitis E virus

Circulating interferon-λ3 and post-vaccination antibodies against the surface antigen of hepatitis B virus in hemodialysis patients exposed to hepatitis E virus

Contact Info

Product

Resources

About