Antibodies to Human Immunodeficiency Virus (HTLV-III/LAV) in People from Lagos and Cross River States of Nigeria

Okpara, Robert A.; Akinsete, I; Williams, Eka; Schneider, J.; Wendler, I.; Hunsmann, G

doi:10.1159/000205728

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…The mothers of the children in our study were at low-risk for infection with HIV-1. This is in agreement with other studies that show a relatively low but significant seroprevalence of HIVI-1 infection in low-and high-risk adult populations in Nigeria [1,[4][5][6]. These surveys indicate that HIV-1 seroprevalence increased from 0 to 0 03-0 3 % in low-risk adults in Northeastern.…”

Section: Discussionsupporting

confidence: 92%

Seroprevalence of HIV-1 and HIV-2 infection among children diagnosed with protein-calorie malnutrition in Nigeria

Fischer¹,

Rinaldo²,

Gbadero³

et al. 1993

Epidemiol. Infect.

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Excessive weight loss due to protein calorie malnutrition (PCM) is a significant problem in Nigerian children. This syndrome may be difficult to differentiate from the wasting disease caused by human immunodeficiency virus type 1 (HIV-1) infection. We studied 70 children admitted to the Baptist Medical Center in Ogbomosho, Nigeria in 1990 with PCM for prevalence of antibodies to HIV-1 and HIV-2. The cohort was from low-risk mothers and had a median age of 25 months (range, 4 months-9 years) with a weight deficit of at least 20% of the theoretical weight for age. Two sera were positive for anti-HIV-1 by both ELISA and Western blot (WB). A high prevalence of samples negative for HIV-1 antibody by ELISA were repeatedly reactive (11%, 8/70) or indeterminate (46%, 32/70) by WB. None of the sera was positive for antibody to HIV-2. There was no correlation of ELISA positivity or extent of WB banding with successful recovery from malnutrition. These results indicate a relatively low but significant prevalence of HIV-1 infection in Nigerian children with PCM. The high prevalence of indeterminate reactions in WB assays for HIV-1 suggests that other procedures may be necessary for confirmatory diagnosis of HIV-1 infection in this African population.

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Section: Discussionsupporting

confidence: 92%

Seroprevalence of HIV-1 and HIV-2 infection among children diagnosed with protein-calorie malnutrition in Nigeria

Fischer¹,

Rinaldo²,

Gbadero³

et al. 1993

Epidemiol. Infect.

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Isolation and characterization of a new subtype A variant of human immunodeficiency virus type I from Nigeria

Olaleye

Sheng

Howard

et al. 1996

Tropical Med Int Health

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SummaryWe have isolated a new variant of HIV-I from Nigeria, Africa. The virus was recovered from the peripheral blood mononuclear cells (PBMCs) of an apparently healthy z3-year-old male from Ibadan, Nigeria. The in vitro studies indicated that the virus was highly cytopathic and replicated well in normal PBMCs, established T-cell lines and the monocytic cell line U937. The highest replicative titre of the virus was obtained in freshly isolated primary macrophage/monocyte cells which also showed the least cytopathology. Most other cultures showed single-cell cytolysis and giant cells, and syncytia were not induced in the HTLV

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Seroprevalence study of HIV‐I, HIV‐II and HTLV‐I among patients at the Dermato‐Venereology Clinic of the Lagos University Teaching Hospital

et al. 1997

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Antibodies to Human Immunodeficiency Virus (HTLV-III/LAV) in People from Lagos and Cross River States of Nigeria

Cited by 6 publications

References 16 publications

Seroprevalence of HIV-1 and HIV-2 infection among children diagnosed with protein-calorie malnutrition in Nigeria

Seroprevalence of HIV-1 and HIV-2 infection among children diagnosed with protein-calorie malnutrition in Nigeria

Isolation and characterization of a new subtype A variant of human immunodeficiency virus type I from Nigeria

Seroprevalence study of HIV‐I, HIV‐II and HTLV‐I among patients at the Dermato‐Venereology Clinic of the Lagos University Teaching Hospital

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