Antibodies to the metacestode of <i>taenia solium</i> in the saliva from patients with neurocysticercosis

Acosta, E.

doi:10.1002/jcla.1860040204

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…Kunz et al 24 , detected antibodies in the 14 serum samples analyzed by ELISA with antigen of vesicular fluid from T. cracisseps and T. solium, with higher reading intensity with T. solium antigen, similar to our results (Fig 1). Otherwise, other authors reported higher sensitivity than us for IgG detection in saliva samples 25,26 .…”

Section: Discussioncontrasting

confidence: 74%

“…These discordant results reinforce the heterogeneity of the humoral immune response involved in the parasite-host interaction in NC. Acosta 26 did not find any difference in IgA detection in saliva samples between the group of patients with NC, the control group and the group with other neurological disorders by ELISA with T. solium total antigen. Although we used the Tcra antigen, we also did not find significant differences among the groups in CSF, serum or saliva samples (p <0.001).…”

Section: Discussionmentioning

confidence: 73%

“…Only the specific antibody of the IgE class was more frequent in serum than in CSF. Acosta 26 , had already reported that there was no significant difference between the results obtained with serum and saliva samples for IgG detection by ELISA with T. solium total antigen, with a better performance for CSF samples. The higher frequency of antibodies in CSF is expected due to the local immune response at the site of lesion and to the compartmentalization of the process.…”

Section: Discussionmentioning

confidence: 93%

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Neurocysticercosis: detection of IgG, IgA and IgE antibodies in cerebrospinal fluid, serum and saliva samples by ELISA with Taenia solium and Taenia crassiceps antigens

Bueno¹,

Vaz

Machado

et al. 2000

Arq. Neuro-Psiquiatr.

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-We assayed samples of cerebrospinal fluid (CSF), serum and saliva from patients with neurocysticercoses, control group and individuals with other parasitoses, by ELISA with Taenia crassiceps vesicular fluid antigen (Tcra) and Taenia solium total antigen (Tso) for the detection of antibodies. The sensitivity for IgG-Tcra was 100% for CSF and serum, and 32.0% for saliva; and for IgG-Tso 100% for CSF, 80.0% for serum and 24.% for saliva. Specificity was 100% for CSF and 80.0% for serum with both antigens, and 100% for saliva with Tcra and 87.5% with Tso. The sensitivity and specificity for IgA-Tcra was, respectively, 40.0% and 100% for CSF, 36.0% and 97.1% for serum, and 4.0% and 90.0% for saliva. IgE detection showed 24.0% sensitivity and 97.1% specificity for serum, with no detection in CSF samples. The search for antibodies revealed the presence of IgG > IgA > IgE in CSF, serum and saliva samples, with IgG being present in all phases of the disease, while IgA/IgE were more frequent in the inactive form.KEY WORDS: cysticercosis, central nervous system, humoral immune response, IgG, IgE, IgA, T. crassiceps.Neurocisticercose: detecção de anticorpos IgG, IgA e IgE em amostras de líquido cefalorraquidiano, soro e saliva por ELISA com antígenos de Taenia solium e Taenia crassiceps RESUMO -Analisamos amostras de líquido cefalorraquidiano (LCR), soro e saliva de pacientes com neurocisticercose, grupo de controle e indivíduos com outras parasitoses, por ELISA com antígenos de líquido vesicular de T. crassiceps (Tcra) e salino total de T. solium (Tso) para a pesquisa de anticorpos. A sensibilidade para IgG-Tcra foi 100% para LCR e soro e 32,0% para saliva, e para IgG-Tso 100% para LCR, 80,0% para soro e 24,0% para saliva. A especificidade foi de 100% para CSF e 80,0% para soro com ambos os antígenos, e 100% para saliva com Tcra e 87,5% com Tso. A sensibilidade e especificidade para IgA-Tcra foi, respectivamente: 40,0% e 100% para LCR, 36,0% e 97,1% para soro, e 4,0% e 90,0% para saliva. A pesquisa de IgE mostrou 24,0% de sensibilidade e 97,1% de especificidade para soro, sem detecção nas amostras de LCR. A pesquisa de anticorpos revelou a presença de IgG > IgA > IgE no LCR, soro e saliva, com presença de IgG em todas as fases evolutivas da doença, enquanto que IgA/IgE foram mais frequentes na forma inativa.

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Section: Discussioncontrasting

confidence: 74%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 93%

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Neurocysticercosis: detection of IgG, IgA and IgE antibodies in cerebrospinal fluid, serum and saliva samples by ELISA with Taenia solium and Taenia crassiceps antigens

Bueno¹,

Vaz

Machado

et al. 2000

Arq. Neuro-Psiquiatr.

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“…Stroehle et al [136] showed that specific anti- T. gondii salivary IgG concentration can be used for the diagnosis of toxoplasmosis disease. Besides that, IgG antibodies to Ags of Taenia solium metacestodes infection can also be detected in saliva samples of intracerebral cysticercosis patients, thus making it useful for the diagnosis of neurocysticercosis disease [137]. …”

Section: Salivary Antibodiesmentioning

confidence: 99%

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Malon

Sadir

Malarvili

et al. 2014

BioMed Research International

189

108

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Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.

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“…In this context, an increasing number of reports dealing with salivary diagnostic tests have been published (12)(13)(14). Saliva is a more accessible fluid and easy to collect, which makes it a very attractive noninvasive procedure.…”

Section: Discussionmentioning

confidence: 99%

Detection of salivary and seric IgG and IgA antipooled pigeon sera activities in patients with pigeon breeder's disease

Mendoza

Baltazares

Ramìrez

et al. 1996

J. Clin. Lab. Anal.

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Pigeon breeder's disease (PBD) is an interstitial lung disease induced by exposure to pigeon antigens. Search of antipigeon antigen antibodies (APSA) in serum or bronchoalveolar lavage is generally used for auxiliary diagnostic purposes. However, APSA can be present in a number of exposed but asymptomatic individuals as well as in patients with other interstitial lung diseases who live in areas where keeping pigeons is a common domestic habit. In this study, saliva was evaluated as an alternative means to serum for APSA detection by ELISA using pooled pigeon sera as antigen. Serum and saliva samples obtained from 17 patients with PBD, 14 with idiopathic pulmonary fibrosis (IPF), 19 asymptomatic relatives (AR) exposed to pigeon antigens, and 27 clinical healthy voluntary subjects (CHVS) were tested for IgG and IgA APSA. Our results showed that both fluids obtained from PBD patients exhibited a significantly higher specific IgG antibody activity compared to the other groups. Serum optical density (O.D.) values for PBD were 1.187 ± 0.738 vs. 0.024 ± 0.033, 0.255 ± 0.471, and 0.204 ± 0.346 for CHVS, AR and IPF, respectively (P < 0.05). Salivary O.D. for PBD were 0.801 ± 0.447 vs 0.010 ± 0.011, 0.104 ± 0.151, and 0.22 ± 0.447 (P < 0.05). In contrast, serum specific IgA did not discriminate between PBD and IPF patients. In addition, although the PBD group exhibited the highest values of IgA salivary APSA, high levels were also observed in saliva specimens from CHVS, a group of normal individuals who deny pigeon exposure. These findings suggest that measurement of IgG salivary APSA can play a role in the evaluation process of patients with pigeon breeder's disease. © 1996 Wiley‐Liss, Inc.

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Antibodies to the metacestode of taenia solium in the saliva from patients with neurocysticercosis

Cited by 9 publications

References 20 publications

Neurocysticercosis: detection of IgG, IgA and IgE antibodies in cerebrospinal fluid, serum and saliva samples by ELISA with Taenia solium and Taenia crassiceps antigens

Neurocysticercosis: detection of IgG, IgA and IgE antibodies in cerebrospinal fluid, serum and saliva samples by ELISA with Taenia solium and Taenia crassiceps antigens

Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Detection of salivary and seric IgG and IgA antipooled pigeon sera activities in patients with pigeon breeder's disease

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