Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways

Cimini, Annamaria; D’Angelo, Barbara; Das, Soumen; Gentile, Roberta; Benedetti, Elisabetta; Singh, Virendra; Monaco, Antonina; Santucci, S.; Seal, Sudipta

doi:10.1016/j.actbio.2012.01.035

Cited by 153 publications

(83 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…88 It is associated with multiple etiologies and pathogenic mechanisms, and Ab-associated free radicals and the resultant oxidative stress are an important part of the mechanism that is involved in the pathogenic cascade. 89 Subsequently, Cimini et al 90 developed an anti-amyloid b-antibody-conjugated CeONP to enhance its specific target to Ab aggregates. They synthesized polyethylene glycol-coated CeONP and subsequently conjugated anti-amyloid b-antibody to it (anti-Ab-CEONP-polyethylene glycol).…”

Section: Cerium Oxide Nanoparticle C Xu and X Qumentioning

confidence: 99%

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

2014

NPG Asia Mater

921

650

View full text Add to dashboard Cite

Section: Cerium Oxide Nanoparticle C Xu and X Qumentioning

confidence: 99%

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

2014

NPG Asia Mater

921

650

View full text Add to dashboard Cite

“…The utilization of nanoceria as oxidase under some special circumstances was also reported. Recently, nanoceria have been used for several applications either in biotic conditions or abiotic conditions, such as antioxidants, [63][64][65] capping [36] and neuroprotection agents, [66][67][68][69][70][71][72] biosensors, [23,28,73] immunoassays, [31,32,74] color indicator [27,[75][76][77][78][79] and so on.…”

Section: Bio-application Prospects Of Nanoceria As Enzyme Mimeticsmentioning

confidence: 99%

“…[66][67][68] Owing to the critical role of amyloid-β peptides (Aβ), degrading Aβ is a promising therapeutic approach to treat AD. [69,70] Ceria/polyoxometalates hybrid (nanoceria@POMs), a biocatalyst with both proteolytic and SOD mimetic activities, was designed by Guan and co-workers.…”

Section: Neuroprotectionmentioning

confidence: 99%

Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

View full text Add to dashboard Cite

In the past decades, enzyme mimetics based on ceria nanoparticles (nanoceria) have been developed as potential substitutes for nature enzymes. The mixed valence states of cerium and the patterns of oxygen vacancies on crystal planes result in different enzyme mimetic activities. In this review we survey the bio-applications of nanoceria-based enzyme mimetics as well as the underlying mechanisms. Factors influencing the enzyme mimetic activities and future perspective of nanoceria-based enzyme mimetics are also addressed.

show abstract

“…After centrifugation, the CNPs were washed with water several times and dried under vacuum. 27,28 Fourier transform infrared spectroscopy (FTIR) with a Bruker Vector-22 instrument (Bruker Daltonics, Billerica, MA, USA) was used to confirm amine functionalization.…”

Section: Synthesis and Characterization Of Cnpsmentioning

confidence: 99%

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

Chen¹,

Zhang²,

Hu³

et al. 2015

IJN

View full text Add to dashboard Cite

Radiotherapy is one of the main strategies for cancer treatment but has significant challenges, such as cancer cell resistance and radiation damage to normal tissue. Radiosensitizers that selectively increase the susceptibility of cancer cells to radiation can enhance the effectiveness of radiotherapy. We report here the development of a novel radiosensitizer consisting of monodispersed ceria nanoparticles (CNPs) covered with the anticancer drug neogambogic acid (NGA-CNPs). These were used in conjunction with radiation in MCF-7 breast cancer cells, and the efficacy and mechanisms of action of this combined treatment approach were evaluated. NGA-CNPs potentiated the toxic effects of radiation, leading to a higher rate of cell death than either treatment used alone and inducing the activation of autophagy and cell cycle arrest at the G2/M phase, while pretreatment with NGA or CNPs did not improve the rate of radiation-induced cancer cells death. However, NGA-CNPs decreased both endogenous and radiation-induced reactive oxygen species formation, unlike other nanomaterials. These results suggest that the adjunctive use of NGA-CNPs can increase the effectiveness of radiotherapy in breast cancer treatment by lowering the radiation doses required to kill cancer cells and thereby minimizing collateral damage to healthy adjacent tissue.

show abstract

Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways

Cited by 153 publications

References 53 publications

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

Ceria Nanoparticles as Enzyme Mimetics

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

Contact Info

Product

Resources

About

Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways

Cited by 153 publications

References 53 publications

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

Ceria Nanoparticles as Enzyme Mimetics

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in&nbsp;breast cancer cells

Contact Info

Product

Resources

About

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells