Ceria Nanoparticles as Enzyme Mimetics

Abstract

In the past decades, enzyme mimetics based on ceria nanoparticles (nanoceria) have been developed as potential substitutes for nature enzymes. The mixed valence states of cerium and the patterns of oxygen vacancies on crystal planes result in different enzyme mimetic activities. In this review we survey the bio-applications of nanoceria-based enzyme mimetics as well as the underlying mechanisms. Factors influencing the enzyme mimetic activities and future perspective of nanoceria-based enzyme mimetics are also addressed.

<p>Cyclodextrin-Modified CeO₂ Nanoparticles as a Multifunctional Nanozyme for Combinational Therapy of Psoriasis</p>

“…The results indicate that the synthesized NPs have a mixed-valence state (Ce 3+ /Ce 4+ ). 21,31,32 The bio-composite complex formation of the synthesized particles was further attested through Fourier transform infrared spectroscopy by analyzing the characteristic peaks involved. As shown in Figure 1F, the presence of β-CDs was confirmed on the nanoceria particle surface.…”

“…CeNPs possess SOD-and catalase-mimicking activities due to the mixed valence states of Ce 3+ and Ce 4+ . 21,31,32 Intracellular ROS Scavenging Detection…”

“…23 Ceria nanoparticles (CeNPs) exhibit tremendous potential as effective antioxidant enzymes, such as peroxidase, oxidase, catalase, and SOD. 31,32 These high-performance ROS reduction capacities originate from the dual oxidation states (Ce 3 + /Ce 4+ ) on the surface of these particles in which Ce 3+ is responsible for eliminating O 2 • − and •OH, while Ce 4+ eradicating H 2 O 2 . 32 CeNPs have been applied to treat various ROSassociated diseases, including ischemic stroke, 33 rheumatoid arthritis, 34 autoimmune degenerative disease.…”

Room-temperature synthesis of nanoceria for degradation of organophosphate pesticides and its regeneration and reuse

“…Thus, the properties and applications of nanoceria are deeply studied as documented by the abundant literature available. [8][9][10] Its properties may be further modied either by doping 11 of its structure or by depositing ceria on a conductive substrate (such as gold 12 ). Nevertheless, only a few studies 13 are devoted to the deep evaluation of the synthesis conditions such as temperature or composition of reaction atmosphere on the synthesis process.…”

Nanoparticles as Emerging Labels in Electrochemical Immunosensors

“…Nanoparticles (NPs) have been extensively studied compared to bulk materials due to their unique features, including their catalytic, electric, optical and magnetic properties, being electrochemical analysis one of the fields with higher potential application [1]. Thanks to their excellent stability against denaturation, ease of mass production, ease of bioconjugation, and lower cost, many NP-based biosensors, mainly DNA sensors [2,3] and immunosensors, have drawn widespread attention in bio nanotechnology, offering benefits compared to traditional methods in terms of time of analysis, sensitivity and simplicity [4,5,6,7,8].…”