2022
DOI: 10.3390/ijms23031200
|View full text |Cite
|
Sign up to set email alerts
|

Antibody Conjugated PLGA Nanocarriers and Superparmagnetic Nanoparticles for Targeted Delivery of Oxaliplatin to Cells from Colorectal Carcinoma

Abstract: Anti-CD133 monoclonal antibody (Ab)-conjugated poly(lactide-co-glycolide) (PLGA) nanocarriers, for the targeted delivery of oxaliplatin (OXA) and superparamagnetic nanoparticles (IO-OA) to colorectal cancer cells (CaCo-2), were designed, synthesized, characterized, and evaluated in this study. The co-encapsulation of OXA and IO-OA was achieved in two types of polymeric carriers, namely, PLGA and poly(lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) by double emulsion. PLGA_IO-OA_OXA and PEGylated PLGA_IO… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
14
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 25 publications
(14 citation statements)
references
References 67 publications
(90 reference statements)
0
14
0
Order By: Relevance
“… 20 , 21 Additionally, PLGA nanoparticles possess free carboxyl end‐groups and can be modified as multifunctional nanoparticles, by connecting other bioactivation agents through covalent bonds. 22 Based on the delivered ability of PLGA, there are three main modification strategies for cancer therapy, namely encapsulation, coating, and covalent modification. Initially, these water‐soluble agents can be encapsulated in the PLGA core, while the hydrophobic agents are loaded in the PLGA shell, forming a core–shell structure.…”
Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning
confidence: 99%
See 1 more Smart Citation
“… 20 , 21 Additionally, PLGA nanoparticles possess free carboxyl end‐groups and can be modified as multifunctional nanoparticles, by connecting other bioactivation agents through covalent bonds. 22 Based on the delivered ability of PLGA, there are three main modification strategies for cancer therapy, namely encapsulation, coating, and covalent modification. Initially, these water‐soluble agents can be encapsulated in the PLGA core, while the hydrophobic agents are loaded in the PLGA shell, forming a core–shell structure.…”
Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning
confidence: 99%
“…As PLGA nanoparticles possess both hydrophilicity and hydrophobicity, they have the potential to form a water/oil/water (W/O/W) core–shell structure by the compatibility principle 20,21 . Additionally, PLGA nanoparticles possess free carboxyl end‐groups and can be modified as multifunctional nanoparticles, by connecting other bioactivation agents through covalent bonds 22 . Based on the delivered ability of PLGA, there are three main modification strategies for cancer therapy, namely encapsulation, coating, and covalent modification.…”
Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning
confidence: 99%
“…On the other hand, nanocarrier-based drug delivery systems have been spotlighted in last several decades due to their superiority in drug targeting issues [ 17 , 18 , 19 , 20 , 21 ]. Due to their small size, nanocarriers are believed to be an ideal candidate for tumor targeting [ 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, nanocarrier-based drug delivery systems have been spotlighted in last several decades due to their superiority in drug targeting issues [ 17 , 18 , 19 , 20 , 21 ]. Due to their small size, nanocarriers are believed to be an ideal candidate for tumor targeting [ 17 , 18 ]. Since the surface of nanocarriers such as polymeric nanoparticles can be easily decorated with targeting moieties such as monoclonal antibodies, they can then be specifically delivered to the tumor with a minimization of side effects against normal cells [ 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation