Antibody-coupled hydroxyapatite nanoparticles as efficient tools for labeling intracellular proteins

Vázquez-Hernández, F.; Mendoza-Acevedo, S.; Mendoza‐Barrera, C.; Mendoza-Álvarez, J.G.; Luna-Arias, Juan Pedro

doi:10.1016/j.msec.2016.10.082

Cited by 13 publications

(5 citation statements)

References 18 publications

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“…It has been shown that half of the elements in the periodic table could be incorporated into HA crystal structure, which paves the way to synthesise a series of HA derivatives. Therefore, HA nanoparticles (NPs) with excellent biocompatibility display promising potentials in biomedical fields, including artificial bone, tissue engineering scaffolds, biological probing, anticancer and antibacterial reagents, and drug delivery system [7][8][9][10][11][12].…”

mentioning

confidence: 99%

Synthesis and characterisation of fluorescent and biocompatible hydroxyapatite nanoparticles with cerium doping

Huang

Zhou

Chen

et al. 2018

Micro & Nano Letters

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In this work, the fluorescent hydroxyapatite nanoparticles (HA NPs) were synthesised by doping cerium (Ce) ions into the crystal structure of HA at different concentrations. The fluorescent property of the Ce-doped HA NPs was determined by the content of Ce doping. The results show that HA NPs with the Ce-doping content of 5% displayed the highest fluorescent emission peak near 380 nm at the excitation wavelength of 300 nm. The CCK-8 assay showed that no significant cytotoxicity was observed when the L929 cells were incubated with the fluorescent HA NPs with the Ce-doping content of 5% for 12 h at the dose lower than 0.1 mg/ml. Therefore, the fluorescent HA NPs could be used as a fluorescent probing for cellular imaging and antioxidant agent against oxidative stress-induced cell damages.

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confidence: 99%

Synthesis and characterisation of fluorescent and biocompatible hydroxyapatite nanoparticles with cerium doping

Huang

Zhou

Chen

et al. 2018

Micro & Nano Letters

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“…52,53 Moreover, HA NPs also has low cytotoxicity and easy to prepare and modify, and are considered ideal carriers for drugs and gene delivery. 54 At present, HA NPs have become an ideal alternative for orthopedic implants due to their unique properties. The physicochemical properties of HA NPs are mainly related to particle size, shape, and surface functional groups, charge, and morphology.…”

Section: Organic Npsmentioning

confidence: 99%

Recent advances of nanoparticles on bone tissue engineering and bone cells

Zhang,

Zhen,

Yang

et al. 2024

Nanoscale Adv.

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“…Te nHAP particles were synthesized using three reported wet methods with slight modifcations: hydrolysis method (nHAP-1) [31], hydrothermal method (nHAP-2, nHAP-4) [32,33], and chemical precipitation (nHAP-3) [34].…”

Section: Synthesis Of Nhapsmentioning

confidence: 99%

Size and Morphology-Mediated Antiproliferative Activity of Hydroxyapatite Nanoparticles in Human Breast Cancer Cells

Fukada

Chhetri

Suresh

et al. 2023

Journal of Nanotechnology

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Hydroxyapatite nanoparticles (nHAPs) have been recognized for potent antitumor effects in certain cancer cells, making them good candidates as drug delivery agents and tumor therapeutics with fewer than normal side effects. This study is aimed to correlate cell proliferation inhibition with the size and morphology of nHAPs in a human breast cancer cell line as well as in normal tissue cells. We present our in vitro experimental evidence that nHAPs with sizes smaller than 50 nm have high inhibitory activity against human MCF-7 breast cancer cell lines. Based on our experimental data, normal fibroblast cells (NIH 3T3) were relatively more viable upon treatment with the nanoconstructs. The present study indicates that nHAPs can be engineered as nontoxic specific inhibitors as efficient breast cancer therapeutics in humans.

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Antibody-coupled hydroxyapatite nanoparticles as efficient tools for labeling intracellular proteins

Cited by 13 publications

References 18 publications

Synthesis and characterisation of fluorescent and biocompatible hydroxyapatite nanoparticles with cerium doping

Synthesis and characterisation of fluorescent and biocompatible hydroxyapatite nanoparticles with cerium doping

Recent advances of nanoparticles on bone tissue engineering and bone cells

Size and Morphology-Mediated Antiproliferative Activity of Hydroxyapatite Nanoparticles in Human Breast Cancer Cells

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