Antibody Response to Campylobacter pylori in Diverse Ethnic Groups

Dwyer, Brian; Kaldor, J.; Tee, Wee; Marakowski, Eugene; Raios, Kerry

doi:10.3109/00365548809032465

Cited by 54 publications

(27 citation statements)

References 3 publications

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“…Serologic studies suggested that the difference in the colonization rates of H. pylori was related to the ethnic backgrounds of the population studied. 24,25 In this study, the seropositive rate for preschool aboriginal children of Hsing-Yi and Jen-Ai townships in Nantou County was higher than that of any other ethnic groups. Similar observations were also reported in another study.…”

Section: Discussionmentioning

confidence: 49%

Seroepidemiology of Helicobacter pylori infection among preschool children in Taiwan.

Lin¹,

Nieh²,

Wang³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. Helicobacter pylori is associated with chronic antral gastritis that is related to duodenal ulcer, gastric ulcer, and probably gastric adenocarcinoma. Infection with H. pylori during childhood is considered an important risk factor for gastric carcinoma in adult life. To examine the epidemiologic characteristics of H. pylori infection among preschool children in central Taiwan, a community-based survey was carried out in 54 kindergartens in 10 urban townships, 10 metropolitan precincts, and 2 aboriginal townships randomly selected through stratified sampling. Serum specimens of 2,551 healthy preschool children (3-6 years old) randomly sampled from study kindergartens were screened for antibodies to H. pylori by latex agglutination and ELISA methods. Multivariate-adjusted odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression analysis. A total of 207 subjects were antibody-positive, giving a prevalence of 8.1%. The overall seropositive rates were 4.5% in 3-year-old group, 4.4% in 4-year-old group, 9.4% in 5-year-old group, and 11.7% in 6-year-old group. The older the age, the higher the seroprevalence (OR ϭ 3.2, 95% CI ϭ 1.5-6.8 for 3-year-old children versus the 6-year-old children). Seroprevalence was not different between boys and girls. The aboriginal townships had a seroprevalence greater than the urban townships and metropolitan precincts (OR ϭ 2.6, 95% CI ϭ 1.9-3.7). The larger the number of siblings, the higher the seroprevalence (OR ϭ 2.4, 95% CI ϭ 1.0-5.8 for those with no sibling versus those with Ն 3 siblings). In the multiple logistic regression analysis, the seroprevalence of H. pylori remained significantly increased with age, aboriginal township, and large sibship size after multivariate adjustment. A poor water supply system, sewage disposal, and other environmental hygiene in the aboriginal townships might have played some role in infection with H. pylori. The early childhood transmission among siblings might also be an important determinant of H. pylori seropositivity in Taiwan.Infection with Helicobacter pylori has been causally related to chronic gastritis and peptic ulcer, and indirectly related to gastric adenocarcinoma and primary gastric B cell lymphoma.

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Section: Discussionmentioning

confidence: 49%

Seroepidemiology of Helicobacter pylori infection among preschool children in Taiwan.

Lin¹,

Nieh²,

Wang³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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“…Several studies have also shown that there are marked differences in the prevalence and ageSpecific frequency of Helicobacter pylori in different populations or in different ethnic groups within a definite population (5,6,23,24). However, most data that are available have been the result of the evaluation of anti-Helicobacter Pylori antibodies in serum samples obtained from Uncharacterized populations, such as blood donors (1)(2)(3)(4)(5)(6)(7)(8)(9), so that selection biases may not have been excluded.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that there are marked differences in the prevalence and age-specific frequency of Helicobacterpylori in different populations. However, most data available have resulted largely from the evaluation of the presence of anti-Helicobacter pylori antibodies in serum samples obtained from uncharacterized populations, such as blood donors, or from subjects that were not randomly selected, so that many biases may not have been excluded (3)(4)(5)(6)(7)(8)(9). Serology has been the most widely employed method for diagnosis of Helicobacterpylori infection, since it is well suited for screening a large number of individuals.…”

Section: Introductionmentioning

confidence: 99%

Use of a urea breath test versus invasive methods to determine the prevalence ofHelicobacter pylori in zaire

Glupczynski

Bourdeaux²,

Verhas

et al. 1992

Eur. J. Clin. Microbiol. Infect. Dis.

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The prevalence of Helicobacter pylori infection in Zaire was determined by means of a [14C] urea breath test in 133 asymptomatic subjects, by culture and histological examination of biopsies in 324 consecutive endoscopy patients with chronic epigastric complaints, and by both the breath test and culture/histology in a subset of 92 patients. Sixty healthy Belgian students or hospital laboratory workers were also included for comparison. The prevalence of Helicobacter pylori was significantly higher in asymptomatic Zairian subjects (77.4%) than in the Belgians (30%; p less than 10(-6)). Infection was also acquired much earlier in life in Africans, 66% of the children aged 5 to 9 years already being infected versus none of the Belgian subjects below the age of 20 years. In Zaire, however, the prevalence of Helicobacter pylori in patients with gastroduodenal disorders (87.5%) was similar to that in the group of asymptomatic subjects (77.5%) after adjustment for age and other epidemiological parameters (gender, place of residency, education level, smoking and drinking habits) in a multivariate analysis. The high rate of acquisition of Helicobacter pylori infection in Zaire emphasizes the need to consider the baseline prevalence of Helicobacter pylori in a defined population when studying its association with various diseases.

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“…Gastric colonization by the organism has been found in 33-79% of patients with functional dyspepsia (4), but similar rates are also found in symptomless individuals (5). The need for careful control of possible confounding by age, socioeconomic status, and ethnicity has been pointed out by several authors (5)(6)(7)(8)(9)(10). Since only about half of the individuals with abdominal symptoms ever see a physician for these complaints (1 l), and because the decision to consult involves selection mechanisms that may also act as confounders in the association between H. pylori and abdominal symptoms (such as socioeconomic factors, education), the role of H. pylori infection is best studied in the general population.…”

mentioning

confidence: 99%

Helicobacter pyloriSeropositivity among Swedish Adults with and without Abdominal Symptoms: A Population-Based Epidemiologic Study

Agréus

Engstrand

Svärdsudd

et al. 1995

Scandinavian Journal of Gastroenterology

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Antibody Response to Campylobacter pylori in Diverse Ethnic Groups

Cited by 54 publications

References 3 publications

Seroepidemiology of Helicobacter pylori infection among preschool children in Taiwan.

Seroepidemiology of Helicobacter pylori infection among preschool children in Taiwan.

Use of a urea breath test versus invasive methods to determine the prevalence ofHelicobacter pylori in zaire

Helicobacter pyloriSeropositivity among Swedish Adults with and without Abdominal Symptoms: A Population-Based Epidemiologic Study

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