Antibody response to unconjugated Haemophilus influenzae b and pneumococcal polysaccharide vaccines in children with recurrent infections

Raby, R.B.; Blaiss, Michael S.; Gross, Sharon; Herrod, Henry G.

doi:10.1016/s0091-6749(96)70170-7

Cited by 10 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the 101 patients examined for antibody against serotype 3, 18 had levels below the protective level of 200 ng/mL. For serotypes 14,19,23,26, and 51, the number of patients with antibody levels Ͻ200 ng/mL was 24, 11, 31, 15, and 16, respectively. The individual antibody levels of each patient for each serotype are depicted in There was a positive correlation between total serum IgG levels and age (Fig 2).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, we found geometric mean titers of 565 ng/mL and 649 ng/mL, respectively, in CF patients of a similar age. Raby et al 14 found that 53% and 37% had antibody levels Ͼ200 ng/mL for serotypes 3 and 14, respectively. Imposing the same age restrictions, our CF patients demonstrated a higher proportion of protective levels of antibody, 72% and 61% for serotypes 3 and 14, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Various sources cite levels between 150 and 500 ng/mL as protective. 14,19,28,31,32 Several reports have suggested that anti-pneumococcal titers Ͼ200 to 300 ng/mL afford the minimum amount of protection against bacteremia. 24,25,33 These earlier studies used RIA to measure antibody levels.…”

Section: Discussionmentioning

confidence: 99%

“…14 For each serotype, a linear regression analysis of the logarithmic transformation of anti-pneumococcal antibody level versus age was performed. 15 A linear regression analysis also was performed for total serum IgG versus age.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Lahiri

Waltz

2001

Pediatrics

View full text Add to dashboard Cite

ABSTRACT. Objective. Although invasive pneumococcal disease is infrequent in cystic fibrosis (CF), it is recommended that all patients with CF receive pneumococcal immunization. As part of a comprehensive program to immunize our clinic population, we obtained preimmunization anti-pneumococcal antibody levels. We hypothesized that the percentage of CF patients without protective levels of anti-pneumococcal antibody levels would be high, as they are exposed to frequent antibiotic therapy that may eradicate organisms before generation of an antibody response.Methods. An observational study of 100 patients with CF, aged 1 to 39 years, was conducted in a regional CF center. Preimmunization anti-pneumococcal antibody levels against 6 serotypes were measured by enzymelinked immunosorbent assay. Protective antibody levels were defined as >200 ng/mL.Results. A majority of CF patients-61% to 100%, depending on age and serotype-had protective levels of pneumococcal antibody. There was a significant positive correlation between antibody level and age for 5 of the 6 serotypes tested.Conclusions. In contradistinction to our hypothesis, the majority of CF patients have protective preimmunization anti-pneumococcal antibody levels. However, a significant proportion-between 17% and 39%, depending on the serotype-did not exhibit adequate levels. Therefore, we concur with current recommendations for pneumococcal immunization in CF. Pediatrics 2001; 108(4). URL: http://www.pediatrics.org/cgi/content/full/ 108/4/e62; cystic fibrosis, Streptococcus pneumoniae, immunization, ELISA.ABBREVIATIONS. CF, cystic fibrosis; ELISA, enzyme-linked immunosorbent assay; RIA, radioimmunoassay.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Lahiri

Waltz

2001

Pediatrics

View full text Add to dashboard Cite

show abstract

“…In some of these children, such infections have a recurrent pattern (2). At present, there are no uniform criteria to define recurrent infection, but several repeated infections in a year should be considered to constitute recurrent infection (9).…”

mentioning

confidence: 99%

Serum Antibody Response to Polysaccharides in Children with Recurrent Respiratory Tract Infections

López-Yap¹,

Abdelnour

Lomonte

et al. 2001

Clin Diagn Lab Immunol

View full text Add to dashboard Cite

We evaluated children (15-months old and older) with recurrent upper respiratory tract infections and normal levels of immunoglobulins in serum for specific polysaccharide immunodeficiency using an enzyme-linked immunosorbent assay method. Results showed that of 12 patients vaccinated with Act-HIB vaccine, one did not develop specific antibodies to Haemophilus influenzae type b, demonstrating that such immunodeficiency is present in Costa Rican children.

show abstract

Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and pneumonia with consolidation on x-ray in children under two years of age

Lucero

Dulalia

Parreno

et al. 2004

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Antibody response to unconjugated Haemophilus influenzae b and pneumococcal polysaccharide vaccines in children with recurrent infections

Cited by 10 publications

References 19 publications

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Serum Antibody Response to Polysaccharides in Children with Recurrent Respiratory Tract Infections

Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and pneumonia with consolidation on x-ray in children under two years of age

Contact Info

Product

Resources

About