Antibody responses of rats after immunization with organic acid anhydrides as a model of predictive testing

Abstract

The following articles refer to this text: 2001;27(2):0; 2001;27(5):0

Exposure assessment and sensitisation in workers exposed to organic acid anhydrides

“…As HHPA was used only in plant C and MHHPA in plant A and plant C, the higher sensitising potency of these OAAs could also be a cause for the high prevalence of sensitisation described (Zhang et al 1998) in these two plants.…”

A prospective study of the relationship between exposure and specific antibodies in workers exposed to organic acid anhydrides

“…Differences in the incidence of sensitization between different OAAs may be explained by different exposure levels, but there may also be differences in sensitizing capacity. Thus, a wide variation in antibody titers was found in guinea pigs (24) and rats (25) after equimolar intradermal immunization of varying OAAs. For the evaluation of the sensitizing potential of OAAs in man, the assessment of exposure–response relationships for varying OAAs should give valuable information.…”

Serum albumins are the major site for in vivo formation of hapten‐carrier protein adducts in plasma from humans and guinea‐pigs exposed to type‐1 allergy inducing hexahydrophthalic anhydride

“…It may be questioned whether these adduct levels are sufficient to induce an immunological response. On the other hand, the levels of HPPA‐SA conjugates may be higher in, for example, the airways and administration of HHPA‐SA conjugate to rats has been shown to induce production of HHPA‐specific antibodies [18]. However, there may of course be other more critical protein bindings, from an immunological point of view, giving rise to antibodies and allergic diseases.…”