Antibody responses of swine following infection with Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae and M. flocculare

Gomes-Neto, João Carlos; Strait, Erin L.; Raymond, Matthew; Ramirez, Alejandro; Minion, F. Chris

doi:10.1016/j.vetmic.2014.08.008

Cited by 43 publications

(26 citation statements)

References 26 publications

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“…hyopneumoniae infection by vertical transmission from sow to piglet during lactation is suggested as the main transmission factor in piglets [18]. The infection can either be followed by clearance of the infection with bacterial maintenance in subclinical animals or be enhanced with subsequent prevalence of lung lesions at slaughter [18, 19, 22]. However, the airborne transmission is an important mechanism of M .…”

Section: Discussionmentioning

confidence: 99%

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Microbiome overview in swine lungs

et al. 2017

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Mycoplasma hyopneumoniae is the etiologic agent of swine enzootic pneumonia. However other mycoplasma species and secondary bacteria are found as inhabitants of the swine respiratory tract, which can be also related to disease. In the present study we have performed a total DNA metagenomic analysis from the lungs of pigs kept in a field condition, with suggestive signals of enzootic pneumonia and without any infection signals to evaluate the bacteria variability of the lungs microbiota. Libraries from metagenomic DNA were prepared and sequenced using total DNA shotgun metagenomic pyrosequencing. The metagenomic distribution showed a great abundance of bacteria. The most common microbial families identified from pneumonic swine’s lungs were Mycoplasmataceae, Flavobacteriaceae and Pasteurellaceae, whereas in the carrier swine’s lungs the most common families were Mycoplasmataceae, Bradyrhizobiaceae and Flavobacteriaceae. Analysis of community composition in both samples confirmed the high prevalence of M. hyopneumoniae. Moreover, the carrier lungs had more diverse family population, which should be related to the lungs normal flora. In summary, we provide a wide view of the bacterial population from lungs with signals of enzootic pneumonia and lungs without signals of enzootic pneumonia in a field situation. These bacteria patterns provide information that may be important for the establishment of disease control measures and to give insights for further studies.

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Section: Discussionmentioning

confidence: 99%

“…hyopneumoniae may remain in the respiratory tract and the pigs are then called ‘carriers’. Therefore, previous infections will not be detected during slaughter [22, 27] and under the field experimental conditions there are no M . hyopneumoniae -free pigs.…”

Section: Discussionmentioning

confidence: 99%

Microbiome overview in swine lungs

et al. 2017

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“…This approach prevented potential confounders such as the presence of cross-reactive antibodies with other swine mycoplasmas, as well as co-infections with other major swine pathogens from impacting the study outcome [5]. As age had been previously shown to not influence disease severity of M. hyosynoviae -associated arthritis, six to twelve week-old CDCD-SPF pigs were used in this study [12].…”

Section: Discussionmentioning

confidence: 99%

“…Control animals (n = 4) received the same medium used to grow this bacterium either IN (n = 3) or IV (n = 1). For this study, six to twelve week old cesarean-derived colostrum-deprived (CDCD) specific-pathogen-free (SPF) pigs were acquired from a herd known to be free of all major swine mycoplasmas including, M. hyopneumoniae , M. hyosynoviae , M. hyorhinis , and M. flocculare , as determined by serology and species-specific conventional or quantitative polymerase chain reaction assays (qPCR) of nasal swab and tonsil scraping fluid samples from all experimental animals [3521]. The pigs were housed in a BSL-2 facility at the ISU-VDL and all husbandry procedures were carried out following routine SPF facility biosecurity protocols to prevent cross-contamination.…”

Section: Methodsmentioning

confidence: 99%

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Two clinical isolates ofMycoplasma hyosynoviaeshowed differing pattern of lameness and pathogen detection in experimentally challenged pigs

et al. 2016

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Mycoplasma (M.) hyosynoviae is known to colonize and cause disease in growing-finishing pigs. In this study, two clinical isolates of M. hyosynoviae were compared by inoculating cesarean-derived colostrum-deprived and specific-pathogen-free growing pigs. After intranasal or intravenous inoculation, the proportion and distribution pattern of clinical cases was compared in addition to the severity of lameness. Tonsils were found to be the primary site of colonization, while bacteremia was rarely detected prior to the observation of clinical signs. Regardless of the clinical isolate, route of inoculation, or volume of inocula, histopathological alterations and tissue invasion were detected in multiple joints, indicating an apparent lack of specific joint tropism. Acute disease was primarily observed 7 to 10 days post-inoculation. The variability in the severity of synovial microscopic lesions and pathogen detection in joint cavities suggests that the duration of joint infection may influence the diagnostic accuracy. In summary, these findings demonstrate that diagnosis of M. hyosynoviae-associated arthritis can be influenced by the clinical isolate, and provides a study platform to investigate the colonization and virulence potential of field isolates. This approach can be particularly relevant to auxiliate in surveillance and testing of therapeutic and/or vaccine candidates.

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Mycoplasmosis

Pieters¹,

Maes²

2019

Diseases of Swine

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Antibody responses of swine following infection with Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae and M. flocculare

Cited by 43 publications

References 26 publications

Microbiome overview in swine lungs

Microbiome overview in swine lungs

Two clinical isolates ofMycoplasma hyosynoviaeshowed differing pattern of lameness and pathogen detection in experimentally challenged pigs

Mycoplasmosis

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