Anticancer activity of fungal taxol derived from Botryodiplodia theobromae Pat., an endophytic fungus, against 7, 12 dimethyl benz(a)anthracene (DMBA)-induced mammary gland carcinogenesis in Sprague dawley rats

Pandi, Mohan; Manikandan, R.; Muthumary, J.

doi:10.1016/j.biopha.2009.03.001

Cited by 55 publications

(19 citation statements)

References 34 publications

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“…Moreover, Navarro et al reported that SOD and GRx activities were increased in the blood of tumor-bearing mice compared with non-tumor-bearing controls (Navarro et al, 1999). In the present study, higher SOD and GRx activities were observed in DMBA rats, although this finding was contrary to that of some previous studies (Pandi et al, 2010;Nandakumar & Balasubramanian, 2012). The discrepancy between SOD and GRx activities in DMBA rats in this study and the previously published studies (Pandi et al, 2010;Nandakumar & Balasubramanian, 2012) which can explain the activation of gene expression by oxidants through antioxidant responsive elements (AREs) (Rushmore et al, 1991).…”

Section: Discussioncontrasting

confidence: 99%

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

Chen¹,

Wu²,

Tseng³

et al. 2017

JAS

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Puerariae Radix (PR) is the root of Pueraria lobata, an herb widely used in traditional Chinese medicine and as a food seasoning. Owing to its potential anti-oxidative ability, the effects of PR on the inhibition of breast tumors were investigated in this study using the 7,12-dimethylbenz[a]anthracene (DMBA)-treated rat model. Thirty-two female Sprague-Dawley rats were randomly assigned to one of four different treatment groups, with or without PR and/or DMBA administration. At the age of 177 days, all rats were sacrificed, the number and size of tumors were recorded, and blood and tissue samples were collected for assessment of hematological parameters, redox status, and tumorigenesis-related factors. We found that PR supplementation decreased tumor incidence and WBC count but increased the IgM levels, and significantly altered the redox status, elevated serum TGF-β levels, and reduced serum VEGF-C and ICAM-1 levels. The mechanism by which PR decreased the incidence of DMBA-induced rat breast tumors might include ameliorating immunity, enhancing the antioxidant status, increasing the hepatic excretion of carcinogenic metabolites of DMBA, and influencing the expression of tumorigenesis-related factors.

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Section: Discussioncontrasting

confidence: 99%

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

Chen¹,

Wu²,

Tseng³

et al. 2017

JAS

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“…The animals were subjected to a single dose of 25 mg DMBA (dissolved in 5 mL of mineral oil)/kg b.wt as described previously 17–19. They were also administered 0.9% saline (5 mL/kg b.wt) for 10 weeks (every other day).…”

Section: Methodsmentioning

confidence: 99%

<em>Ulva lactuca</em> polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation

Abd-Ellatef¹,

Ahmed²,

Abdel-Reheim³

et al. 2017

BCTT

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BackgroundRecently, several research studies have been focused on the isolation and function of the polysaccharides derived from different algal species, which revealed multiple biological activities such as antioxidant and antitumor activities. This study assesses the possible breast cancer chemopreventive properties of common seaweeds, sea lettuce, Ulva lactuca (ulvan) polysaccharides using in vitro bioassays on human breast cancer cell line (MCF-7) and an in vivo animal model of breast carcinogenesis.MethodsCytotoxic effect of ulvan polysaccharides on MCF-7 was tested in vitro. For an in vivo investigation, a single dose of 25 mg/kg body weight 7,12-dimethylbenz[a]anthracene (DMBA) and ulvan polysaccharides (50 mg/kg body weight every other day) for 10 weeks were administered orally to the Wistar rats.ResultsDeleterious histopathological alterations in breast tissues including papillary cyst adenoma and hyperplasia of ductal epithelial lining with intraluminal necrotic materials and calcifications were observed in the DMBA-administered group. These lesions were prevented in the DMBA-administered group treated with ulvan polysaccharides. The immunohistochemical sections depicted that the treatment of DMBA-administered rats with ulvan polysaccharides markedly increased the lowered pro-apoptotic protein, p53, and decreased the elevated anti-apoptotic marker, bcl2, expression in the breast tissue. The elevated lipid peroxidation and the suppressed antioxidant enzyme activities in DMBA-administered control were significantly prevented by the treatment with ulvan polysaccharides. The elevated levels of inflammatory cytokines tumor necrosis factor-α and nitric oxide were significantly ameliorated in DMBA-administered rats treated with ulvan polysaccharides as compared to DMBA-administered control.ConclusionIn conclusion, ulvan polysaccharides at the level of initiation and promotion might have potential chemopreventive effects against breast carcinogenesis. These preventive effects may be mediated through the augmentation of apoptosis, suppression of oxidative stress and inflammation, and enhancement of antioxidant defense system.

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“…The isolation of Taxol-producing endophyte Taxomyces anderanae has provided a different approach to find a cheaper and additional product via microorganism fermentation [130]. Taxol has also been found in a amount of unusual genera of fungal endophytes either related or not to yews, such as Taxodium distichum [93] ;Wollemia nobilis [134]., Phyllosticta spinarum [94]; Bartalinia robillardoides [42] ;Pestalotiopsis terminaliae [42] ;Botryodiplodia theobromae [95].…”

Section: Anticancer Compoundsmentioning

confidence: 99%

Current Understanding of Endophytes: Their Relevance, Importance, and Industrial Potential

Tidke¹,

KL²,

Ramakrishna³

et al. 2017

IOSR JBB

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Anticancer activity of fungal taxol derived from Botryodiplodia theobromae Pat., an endophytic fungus, against 7, 12 dimethyl benz(a)anthracene (DMBA)-induced mammary gland carcinogenesis in Sprague dawley rats

Cited by 55 publications

References 34 publications

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

Suppressive Effects of Puerariae Radix on the Breast Tumor Incidence in Rats Treated with DMBA

<em>Ulva lactuca</em> polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation

Current Understanding of Endophytes: Their Relevance, Importance, and Industrial Potential

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