Anticancer activity of galactoxyloglucan polysaccharide-conjugated doxorubicin nanoparticles: Mechanistic insights and interactome analysis

Galactoxyloglucan-doxorubicin nanoparticles exerts superior cytotoxic effects on cancer cells⿿A mechanistic and in silico approach

“…Dox encapsulation with PST001 by the process of ionic gelation with TPP fashioned PST-Dox nanoparticles that possessed greater therapeutic effectiveness in terms of excellent in vitro cytotoxicity, pHresponsive Dox release, tumor specific bio-distribution and a higher LD 50 in mice compared to parental Dox [9] with significant tumor load reduction in both ascetic and solid tumor bearing mice [10]. A detailed mechanistic and interactome network exploration of PST-Dox action exposed the down-regulation of kinases, indicating the potential inhibitory action on tyrosine kinase oncogenic pathways, which was confirmed in the translational level also [11].…”

“…The superior cytotoxicity of the nanoparticles on cervical and ovarian cancer cells over the parent counterparts PST0001 and Dox could be an additive effect acquired at the time of formulation. However, the cytotoxic effect of PST-Dox on normal cell lines was not yet performed even though the toxicity of the nanoparticles on mice models was done previously [9][10][11]. The non-toxic behaviour illustrated by of PST-Dox on normal cells could be due to the presence of PST001 which is a strong immunomodulator and non-toxic polysaccharide.…”

An Overview of Naturally Synthesized Metallic Nanoparticles

“…A PST-Dox nanoparticle was reported with non-toxic to normal lymphocytes up to certain dosage (Joseph et al, 2015). DPM@PL (DTX loaded methoxy polyethylene glycol-ss-vitamin E succinate (PSV) micelles (DPM) @ PPV-based liposomes) have shown inhibition of in situ tumour growth and pulmonary metastasis formation by DTX-inducing the apoptosis and decreased level of metastasis-promoting protein formation.…”

“…Currently, the field of nanotechnology plays a major role in the cancer treatment through drug delivery method because of the good pharmacokinetic activity, better drug solubility, increased the halflife period of drugs. In addition to that they also have less toxic phytochemicals with target-specific nanoparticles which provide a new way of treating cancer (Joseph et al, 2015). Benelli, 2016 stated that nanodrugs with multipotency against mosquito-borne diseases and cancers are required.…”

Folate-decorated poly(3-hydroxybutyrate-co-3-hydroxyoctanoate) nanoparticles for targeting delivery: optimization andin vivoantitumor activity

“…Various formulations are available to reduce these side effects and improve therapeutic efficacy, e.g. using of microspheres, micelles, nanoparticles or targeted nanoparticles (Yoo & Park, 2004;Tan et al, 2005;Sadighian et al, 2014;Joseph et al, 2015). Polymers may also play an important role in preparing various drug formulations.…”