Anticancer Activity of New Copper(ii) Complexes Incorporating a Pyridoxal-Semicarbazone Ligand

Jevtović, Violeta; Ivković, Sonja; Kaišarević, Sonja; Kovačević, Radmila

doi:10.5767/anurs.cmat.100102.en.133j

Cited by 15 publications

(9 citation statements)

References 33 publications

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“…These results indicate that metal complexes of Schiff bases derived from pyridoxal and various amino acids are involved in biological reactions. Copper complexes of pyridoxal Schiff base derivatives exhibit potential antimicrobial [19] and anticancer activities [20].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, spectral characterization and biological exploration of water soluble Cu(II) complexes of vitamin B6 derivative

Annaraj¹,

Neelakantan²

2015

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, spectral characterization and biological exploration of water soluble Cu(II) complexes of vitamin B6 derivative

Annaraj¹,

Neelakantan²

2015

European Journal of Medicinal Chemistry

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“…Most bacterial diseases can be treated with antibiotics, although antibiotic-resistant strains have started to emerge [22,23]. Cancer is undoubtedly one of the main health concerns facing our society and is a leading cause of death worldwide [24]. It is a disease characterised by the uncontrolled cell proliferation and the ability to invade other tissues and organs [25,26].…”

Section: Introductionmentioning

confidence: 99%

Growth, characterisation and applications of L lysine zinc sulphate crystals

Sagunthala¹,

Yasotha²

2019

SN Appl. Sci.

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L lysine zinc sulphate single crystals were developed by solution growth slow evaporation method at ambient temperature using deionised water solvent. Single and powder XRD confirmed the crystalline nature and the lattice parameters identified that the grown crystal crystallised in monoclinic crystal system with the space group of C 2/c. FTIR analysis substantiated the findings of XRD. Optical analysis proved that the grown crystal had wide transparency window (78%) with the lower cut off value 230 nm and its band gap energy was 5.3 eV. High dielectric constant and high dielectric loss at low frequency and vice versa guaranteed their applications. When assayed against select bacterial strains and in vitro human cervical cancer cell line (HeLa), the grown crystal established its efficiency as potential pharmaceutical drug. It showed 100% cancer cell inhibition at very low sample concentration of 50 μg/ml with the IC 50 value of 28.84 μg/ml.

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“…It is endowed with multiple applications like antihistamine activity, pharmacological activities such as antifungal, antiinflammatory, antimicrobial, anticonvulsant, antitumor, anticancer etc. It shows increased potency upon complexation with copper soaps [1][2][3][4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Surface Active Properties of Some Bioactive Azole Series Complexes of Copper in Binary Solvent Mixture

2017

JCBSC

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The importance of colloidal surfactants containing nitrogen and sulphur donor ligands in applied areas of research and many industrial processes cannot be under estimated. Colloido chemical behavior of complexes derived from copper (II) palmitate with substituted phenylthiourea and substituted 2-amino Benzothiazole in benzenepropanol mixture of varying composition has been investigated by viscometric measurement. The combination is found to posses fungicidal, insecticidal, pesticidal and nematocidal activities. The azole and azine ring compounds are very good pharmacological agents and can be used as antimalarial, antimotion sickness, antihistaminic and analgesic. The combination of copper soap and ligand makes complexes which are highly biodegradable and play important role in biological activities. The interaction of these N donor ligands with metal ion gives complexes of different geometries and literature survey reveals that these complexes are potentially more biologically active. Complexes of copper (II) palmitate with N-donor ligands were synthesized and characterized by their elemental analysis, metal weight, m.pt, IR and NMR spectral studies. Copper soaps due to their surface active properties play a vital role in various fields. Complexes containing copper palmitate show remarkable applications in industries and are used as emulsifiers, foaming and wetting agents and dispersing agents. In the present work benzene and propanol have been chosen as the cosolvent as mixed solvents have tendency to interact with complex molecules and affect the aggregation of complex molecules.

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Anticancer Activity of New Copper(ii) Complexes Incorporating a Pyridoxal-Semicarbazone Ligand

Cited by 15 publications

References 33 publications

Synthesis, crystal structure, spectral characterization and biological exploration of water soluble Cu(II) complexes of vitamin B6 derivative

Synthesis, crystal structure, spectral characterization and biological exploration of water soluble Cu(II) complexes of vitamin B6 derivative

Growth, characterisation and applications of L lysine zinc sulphate crystals

Surface Active Properties of Some Bioactive Azole Series Complexes of Copper in Binary Solvent Mixture

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