Anticancer activity of pomegranate extract: effect on hematological and antioxidant profile against ehrlich-ascites-carcinoma in Swiss albino mice

Uddandrao, V. V. Sathibabu; Parim, Brahmanaidu; Nivedha, P. R.; Swapna, K.; Rameshreddy, P.; Vadivukkarasi, S.; Begum, Mustapha Shabana; Saravanan, G.

doi:10.1007/s13596-018-0348-4

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…It is increasingly used in cosmetic, pharmaceutical and nutraceutical fields for its antioxidant, anti-inflammatory, anti-microbial and antiproliferative properties, related to the presence of several bioactive phytochemicals of very different size and polarity [42]. In particular, pomegranate peel extract has attracted much attention for colorectal cancer preventive properties related to the anti-inflammatory, pro-apoptotic and antiproliferative activity of the bioactive tannins both in vitro and in vivo [43][44][45]. However, the potential role of pomegranate polyphenols present in juice extract in current chemotherapeutic anticancer protocols to prevent and alleviate intestinal injury induced by 5-fluorouracil (5-FU) on non-tumorigenic intestinal epithelial cells has been scarcely reported.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

et al. 2020

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Intestinal epithelial cells (IECs) play a pivotal role in maintaining intestinal homeostasis. Different noxious agents, among them also anticancer therapies, can impair intestinal epithelial integrity triggering inflammation and oxidative stress. A frequent complication of chemotherapy is gastrointestinal mucositis, strongly influencing the effectiveness of therapy, increasing healthcare costs, and impairing patients’ quality of life. Different strategies are used to treat gastrointestinal mucositis, including products from natural sources. Our study focused on the effect of pomegranate (Punica granatum L.) juice extract on IEC-6 cells, both during inflammatory conditions and following treatment with 5-fluorouracil (5-FU). The polyphenolic profile of pomegranate juice was characterized in detail by Online Comprehensive two dimensional Liquid Chromatography-Mass Spectrometry. The evaluation of pomegranate juice extract in IEC-6 indicates a significant inhibition in proinflammatory factors, such as cytokines release, cyclooxygenase-2 and inducible nitric oxide synthase expression, and nitrotyrosine formation. Pomegranate also inhibited oxidative stress and adhesion protein expression. In 5-FU-treated IEC-6, pomegranate also inhibited both inflammatory and oxidative stress parameters and apoptosis. It promoted wound repair and tight junction expression. These results suggest a potential use of pomegranate as an adjuvant in the treatment of intestinal inflammatory and oxidative stress states, which also occur during chemotherapy-induced mucositis.

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Section: Discussionmentioning

confidence: 99%

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

et al. 2020

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“…Uddandrao et al 6 examined the Ehrlich-ascites-carcinoma (EAC)-bearing Swiss albino mice and the aqueous pomegranate (Punica granatum extract) fruit extract's (PGET) anticancer efficacy. PGET was given intraperitoneally to EAC-bearing mice at dosages of 100, 200, and 400 mg/kg body weight (BW) for 14 days in a row.…”

Section: Resultsmentioning

confidence: 99%

“…Pomegranate (Punica granatum L.) extract's anti-cancer properties were examined by Uddandrao et al 6 in Ehrlich-Ascitescarcinoma (EAC)-carrying Swiss albino mice. Pomegranate significantly reduced tumor size, viable cell count, tumor weight, and prolonged life in mice suffering EAC.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the Growth of Tumors Induced Ehrlich Ascites by Pre-Treatment with Pomegranate and Beetroot Juice in Mice

Hemdan¹

2022

PJMHS

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The present study was to investigate the antioxidant and antitumor effects of three natural juice (pomegranate, beetroot, and both of them pomegranate and beetroot) injected with Ehrlich ascites carcinoma (EAC) - bearing female mice. The results show that pomegranate and beetroot juice extract is notable sources of phenolic acids and flavonoids. The biological experimental were distributed into six mice groups, the control negative group, and the resultant mice were injected with EAC. The mice were divided into a control EAC positive, group (3) EAC and injected with cisplatin, in addition, the EAC (4, 5, and 6) groups were separately taken orally with pomegranate, beetroot, and both pomegranate and beetroot. The total blood count, hepatic lipid peroxidation index, thiobarbituric acid-reactive substances (TBARS), catalase enzyme activity (CAT), and glutathione peroxidase (GPx) levels were evaluated, as well as liver sections were histopathological examined. In mice harboring EAC, there was a reduction in CAT and GPx activity and an increase in TBARS content. Pomegranate, beetroot, and both pomegranate and beetroot juice treatments improved the complete blood count, the negative changes in the liver enzymes, and the histopathological changes in liver sections. These improvements included increased antioxidant activities, decreased lipid peroxidation, inhibition of EAC cell proliferation, and induction of apoptosis. From the results, it could be concluded that the pomegranate and beetroot had the highest contained phenolic and flavonoid content. As a result, it can prevent the biochemical and histological alterations brought on by EAC without having any negative side effects. Keywords: Pomegranate, Beetroot juice, Ehrlich Ascites carcinoma, Cisplatian, Cancer

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Section: Pomegranate (Punica Granatum)mentioning

confidence: 99%

“…Moreover, an in vivo study has shown that aqueous extract of pomegranate fruit has anticancer activity against Ehrlich-ascites-carcinoma (EAC)-bearing Swiss albino mice. After intraperitoneal injection of mice with pomegranate aqueous extract, a significant reduction has occurred in tumor volume and weight, as well as, decreased viable cell count and improvement in the life span of EAC bearing mice [ 145 ]. In another study, pomegranate fruit juice and two of its components (ellagic acid and luteolin) have been shown to reduce cell viability of ovarian cancer cell line (A2780), inhibit metastasis via down-regulation of matrix metalloproteinases MMP2 and MMP9.…”

Section: Herbal Infusions Antioxidant and Anticancer Capacitiesmentioning

confidence: 99%

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

et al. 2020

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The release of reactive oxygen species (ROS) and oxidative stress is associated with the development of many ailments, including cardiovascular diseases, diabetes and cancer. The causal link between oxidative stress and cancer is well established and antioxidants are suggested as a protective mechanism against cancer development. Recently, an increase in the consumption of antioxidant supplements was observed globally. The main sources of these antioxidants include fruits, vegetables, and beverage. Herbal infusions are highly popular beverages consumed daily for different reasons. Studies showed the potent antioxidant effects of plants used in the preparation of some herbal infusions. Such herbal infusions represent an important source of antioxidants and can be used as a dietary protection against cancer. However, uncontrolled consumption of herbal infusions may cause toxicity and reduced antioxidant activity. In this review, eleven widely consumed herbal infusions were evaluated for their antioxidant capacities, anticancer potential and possible toxicity. These herbal infusions are highly popular and consumed as daily drinks in different countries. Studies discussed in this review will provide a solid ground for researchers to have better understanding of the use of herbal infusions to reduce oxidative stress and as protective supplements against cancer development.

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Anticancer activity of pomegranate extract: effect on hematological and antioxidant profile against ehrlich-ascites-carcinoma in Swiss albino mice

Cited by 12 publications

References 26 publications

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

Inhibition of the Growth of Tumors Induced Ehrlich Ascites by Pre-Treatment with Pomegranate and Beetroot Juice in Mice

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

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