The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

Talib, Wamidh H.; Al-ataby, Israa A.; Mahmod, Asma Ismail; Jawarneh, Sajidah; Kury, Lina T. Al; Al-Yasari, Intisar Hadi

doi:10.3390/molecules25184207

Cited by 21 publications

(17 citation statements)

References 219 publications

(216 reference statements)

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“…Various techniques used for this purpose differ in terms of repeatability and costs associated with the necessity of using specialized equipment. Valuable reviews, published in recent years, describe problems related to (i) the mechanisms responsible for the antioxidant activity [ 17 ]; (ii) the antioxidant activity of natural extracts prepared from various plant species [ 36 ], microorganisms [ 37 ], and food ingredients [ 38 ]; and (iii) the preventive role of antioxidants in various diseases such as diabetes [ 39 ], human gut diseases [ 40 ], and cancer [ 41 ], as well as the use of natural extracts for the synthesis of nanoparticles [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

et al. 2021

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Natural extracts are the source of many antioxidant substances. They have proven useful not only as supplements preventing diseases caused by oxidative stress and food additives preventing oxidation but also as system components for the production of metallic nanoparticles by the so-called green synthesis. This is important given the drastically increased demand for nanomaterials in biomedical fields. The source of ecological technology for producing nanoparticles can be plants or microorganisms (yeast, algae, cyanobacteria, fungi, and bacteria). This review presents recently published research on the green synthesis of nanoparticles. The conditions of biosynthesis and possible mechanisms of nanoparticle formation with the participation of bacteria are presented. The potential of natural extracts for biogenic synthesis depends on the content of reducing substances. The assessment of the antioxidant activity of extracts as multicomponent mixtures is still a challenge for analytical chemistry. There is still no universal test for measuring total antioxidant capacity (TAC). There are many in vitro chemical tests that quantify the antioxidant scavenging activity of free radicals and their ability to chelate metals and that reduce free radical damage. This paper presents the classification of antioxidants and non-enzymatic methods of testing antioxidant capacity in vitro, with particular emphasis on methods based on nanoparticles. Examples of recent studies on the antioxidant activity of natural extracts obtained from different species such as plants, fungi, bacteria, algae, lichens, actinomycetes were collected, giving evaluation methods, reference antioxidants, and details on the preparation of extracts.

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Section: Introductionmentioning

confidence: 99%

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

et al. 2021

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“…Natural products are widely used as health supplements and drugs worldwide, particularly in Asia. They are safe and relatively inexpensive, and investigators support the opinion that natural products exhibit anticancer effects and improve prognosis in various types of cancers [ 84 , 85 , 86 , 87 ]. In recent years, increased risk of toxicity and reduction of antioxidant activity by uncontrolled and excessive consumption of natural products and their extracts has become problematic [ 86 ].…”

Section: Natural Productsmentioning

confidence: 99%

“…They are safe and relatively inexpensive, and investigators support the opinion that natural products exhibit anticancer effects and improve prognosis in various types of cancers [ 84 , 85 , 86 , 87 ]. In recent years, increased risk of toxicity and reduction of antioxidant activity by uncontrolled and excessive consumption of natural products and their extracts has become problematic [ 86 ]. Therefore, it is essential to understand the detailed molecular mechanisms of their biological activities for application of natural products and their extracts in cancer therapy.…”

Section: Natural Productsmentioning

confidence: 99%

“…Therefore, it is essential to understand the detailed molecular mechanisms of their biological activities for application of natural products and their extracts in cancer therapy. Regulation of ROS production is one of the important mechanisms in the pharmacological application of natural products [ 86 , 88 ]. However, most studies have discussed the relationship between ROS production and anticancer effects in terms of intracellular ROS, and not mROS.…”

Section: Natural Productsmentioning

confidence: 99%

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Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers

et al. 2020

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Oxidative stress plays an important role in cellular processes. Consequently, oxidative stress also affects etiology, progression, and response to therapeutics in various pathological conditions including malignant tumors. Oxidative stress and associated outcomes are often brought about by excessive generation of reactive oxygen species (ROS). Accumulation of ROS occurs due to dysregulation of homeostasis in an otherwise strictly controlled physiological condition. In fact, intracellular ROS levels are closely associated with the pathological status and outcome of numerous diseases. Notably, mitochondria are recognized as the critical regulator and primary source of ROS. Damage to mitochondria increases mitochondrial ROS (mROS) production, which leads to an increased level of total intracellular ROS. However, intracellular ROS level may not always reflect mROS levels, as ROS is not only produced by mitochondria but also by other organelles such as endoplasmic reticulum and peroxisomes. Thus, an evaluation of mROS would help us to recognize the biological and pathological characteristics and predictive markers of malignant tumors and develop efficient treatment strategies. In this review, we describe the pathological significance of mROS in malignant neoplasms. In particular, we show the association of mROS-related signaling in the molecular mechanisms of chemically synthesized and natural chemotherapeutic agents and photodynamic therapy.

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“…Os produtos naturais derivados de plantas são considerados os medicamentos mais antigos do mundo. Na medicina popular, as plantas são usadas para tratar diferentes doenças e infecções, ou mesmo para a prevenção das mesmas (Talib et al, 2020). Por conta disso, cerca de 40% dos medicamentos comercializados em farmácias são de origem vegetal, aumentando o interesse de estudos nessa área (Azevedo et al, 2011).…”

Section: Introductionunclassified

Estudo comparativo da composição fenólica e atividades antioxidante e antibacteriana de chás industrializados e artesanais

Piza

Silva

Bruzadelli

et al. 2021

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A demanda por alimentos naturais com atividades biológicas vem crescendo cada vez mais no mundo. Nesse contexto, os chás são considerados as bebidas mais consumidas no mundo todo por conta de suas composições fitoquímicas e atividades biológicas. O presente trabalho visou avaliar e comparar a composição fenólica e atividades antioxidante e antibacteriana de chás industrializados e artesanais de Camellia sinensis, Peumus boldus e Ilex paraguariensis. As infusões foram preparadas adicionando-se 100 mL de água destilada a 100 ºC em 1 g da erva em temperatura ambiente por 10 minutos. A análise de compostos fenólicos totais foi realizada utilizando-se o método do Folin-Ciocalteau. Para a análise de atividade antioxidante, o método do sequestro de radical livre DPPH foi utilizado, sendo os resultados expressos como porcentagem de sequestro. Para a análise de atividade antibacteriana utilizou-se o método de difusão em ágar contra as bactérias Staphylococcus aureus e Escherichia coli. A amostra que apresentou o maior teor fenólico foi a versão industrializada do chá verde, seguida da versão industrializada do chá de boldo e da artesanal do chá verde, que não diferiram estatisticamente. O chá verde artesanal apresentou a maior atividade antioxidante, seguido da sua versão industrializada. Quanto à atividade antibacteriana, não houve a formação de halo de inibição. Por possuir maior teor fenólico, os chás industrializados apresentam-se como uma promissora opção para os consumidores, porém, mais pesquisas são necessárias para evidenciar os compostos destes produtos, além de analisar outras atividades biológicas.

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The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

Cited by 21 publications

References 219 publications

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers

Estudo comparativo da composição fenólica e atividades antioxidante e antibacteriana de chás industrializados e artesanais

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