Anticancer activity of protein fractions from chia (<i>Salvia hispanica L</i>.)

Quintal-Bojórquez, Nidia del Carmen; Carrillo-Cocom, Leydi Maribel; Hernández-Álvarez, Alan Javier; Campos, Maira Rubí Segura

doi:10.1111/1750-3841.15780

Cited by 19 publications

(9 citation statements)

References 40 publications

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“…In a model of mammary gland adenocarcinoma in mouse, Espada et al 24 investigated the effects of Carthamus tinctorius and Salvia hispanica oil on eicosanoid synthesis, growth, and metastasis. In the present study, the aqueous extract of Chia seeds crude inhibited cell proliferation and induced apoptotic cell death of the cancer cell lines, Quintal-Bojórquez et al 25 demonstrated that the present low molecular weight peptides , obtained from chia seeds, as a potential adjuvant option for treatment of cancer.…”

Section: Discussionsupporting

confidence: 53%

Potential effect of Chia Seeds Crude Extract Nanoparticles on Mcf-7 Breast Cancer Cell Line

Shaer¹,

Al-Abbas²

2022

Al-Azhar International Medical Journal

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Section: Discussionsupporting

confidence: 53%

Potential effect of Chia Seeds Crude Extract Nanoparticles on Mcf-7 Breast Cancer Cell Line

Shaer¹,

Al-Abbas²

2022

Al-Azhar International Medical Journal

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“…Seed mucilages may reduce the risk of colon cancer and rectal cancer, and could help protect against coronary heart diseases [76]. Salvia (sage), from the family Lamiaceae, comprises about 1000 species and is wellrecognized for its medical, food, and feed applications [77]. Two species of sage-Salvia hispanica and S. macrosiphon-have attracted the greatest interest from researchers and industry.…”

Section: Application Of Plant-derived Mucilagementioning

confidence: 99%

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

et al. 2021

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Plant mucilage is a renewable and cost-effective source of plant-based compounds that are biologically active, biodegradable, biocompatible, nontoxic, and environmentally friendly. Until recently, plant mucilage has been of interest mostly for technological purposes. This review examined both its traditional uses and potential modern applications in a new generation of health-promoting foods, as well as in cosmetics and biomaterials. We explored the nutritional, phytochemical, and pharmacological richness of plant mucilage, with a particular focus on its biological activity. We also highlighted areas where more research is needed in order to understand the full commercial potential of plant mucilage.

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“…Karami, Peighambardoust, Hesari, Akbari‐Adergani, and Andreu ( 2019a ) also reported that wheat germ protein hydrolysates obtained by alcalase, pepsin, or proteinase K had significant antioxidant activities and the ability to decrease A549 cell viability in a concentration‐dependent manner. In a very recent study, anticancer activity and apoptotic potential of pepsin and pancreatin polypeptides from chia ( Salvia hispanica ) protein (Quintal‐Bojórquez et al, 2021 ) and pepsin hydrolysates from Amaranthus cruentus protein (Ramkisson et al, 2020 ) were proven.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical, antioxidant, antimicrobial, and in vitro cytotoxic activities of corn pollen protein hydrolysates obtained by different peptidases

Akbarmehr

Peighambardoust

Ghanbarzadeh

et al. 2023

Food Science & Nutrition

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The applications of protein hydrolysates as food preservatives and nutraceutical ingredients have attracted much attention because of their beneficial effects. The interest in these ingredients has shifted toward their biological activities with benefits to human health. Bioactive peptides are known as antioxidant agents that could promote health‐promoting effects and prolong food shelf‐life beyond their basic nutritional value. Thus, the aim of this study was to investigate antioxidant, antimicrobial, and in vitro cytotoxic properties of corn pollen protein (CPP) hydrolysates obtained by different enzymes. Proteolytic activity in terms of degree of hydrolysis (DH) and SDS‐PAGE analysis was measured in pancreatin (H‐Pan), pepsin (H‐Pep), and trypsin (H‐Tri) hydrolysates. Amino acid composition, antioxidant and antimicrobial activities, and cytotoxicity of hydrolysates were evaluated. DH and SDS‐PAGE revealed higher proteolytic activity of pepsin compared to other enzymes. Amino acid analysis showed that the functional amino acids such as antioxidant types were most predominant in H‐Pep compared to two other samples. Antioxidant activity of hydrolysates was found to be affected by the type of enzyme and the concentration of hydrolysates. There was a significant difference ( p < 0.05) between antioxidant activity of different hydrolysates. The highest antioxidant activity in terms of Trolox equivalent antioxidant capacity (0.23–2.75 mM), DPPH (33.3%–64.8%), and hydroxyl (33.7%–63.2%) radical scavenging activities, chelation of iron (33.2%–62.5%) and copper (30.2%–50.5%) metals, and total antioxidant activity (0.65–0.85) was obtained for H‐Pep followed by H‐Pan and H‐Tri samples. Antibacterial tests showed that pepsin‐hydrolyzed protein was not significantly ( P > 0.05) effective against E. coli at any concentrations, however, it showed significant ( P < 0.05) concentration‐dependent effect against S. aureus (with inhibition zones of 15–25 mm). Cytotoxicity results revealed that CPP, as a nonhydrolyzed protein, did not generally show antiproliferative activity, however, a significant ( P < 0.05) ability of H‐Pep hydrolysate in decreasing HT‐29 colon cancer cell line viability was seen in a concentration‐dependent manner (the lowest cell viability of 32% at 5 mg/mL). Overall, investigating the application of protein‐based hydrolysates is one of the possible strategies that govern their applied intentions as preservatives and nutraceuticals in the food and pharmaceutical industries.

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Anticancer activity of protein fractions from chia (Salvia hispanica L.)

Cited by 19 publications

References 40 publications

Potential effect of Chia Seeds Crude Extract Nanoparticles on Mcf-7 Breast Cancer Cell Line

Potential effect of Chia Seeds Crude Extract Nanoparticles on Mcf-7 Breast Cancer Cell Line

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

Physicochemical, antioxidant, antimicrobial, and in vitro cytotoxic activities of corn pollen protein hydrolysates obtained by different peptidases

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