Anticancer activity of Pupalia lappacea on chronic myeloid leukemia K562 cells

Alvala, Ravi; Alvala, Mallika; Venkatesh, Sama; Kalle, Arunasree M.; Irlapati, Vamshi K.; Reddy, B. Madhava

doi:10.1186/2008-2231-20-86

Cited by 21 publications

(13 citation statements)

References 31 publications

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“…G2/M arrest and a marked increase in apoptotic rate were noted in neuroblastoma LAN-5 cells [ 24 ]. Rutin present in ethanolic extract of aerial parts of Pupalia lappacea also exerted effects on leukemia K562 cells by functionalizing intrinsic pathway mediated apoptosis [ 25 ]. Extract of Cyrtosperma johnstonii contains rutin as a bioactive ingredient and has potent biological activity against small cell lung carcinoma cells as evidenced by cell cycle arrest and apoptosis [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Rutin mediated targeting of signaling machinery in cancer cells

et al. 2014

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Progress in our understanding of molecular oncology has started to shed light on dysregulation of spatio-temporally controlled signaling pathways, inactivation of tumor suppressor genes, tumour and normal stem cell quiescence, overexpression of oncogenes, extracellular and stromal microenvironments, epigenetics and autophagy. Sequentially and characteristically it has been shown that cancer cells acquire the ability to escape from apoptotic cell death, proliferate uncontrollably, sustain angiogenesis and tactfully reconstitute intracellular pathways to avoid immune surveillance. We have attempted to provide a recent snapshot of most recent progress with emphasis on how rutin modulates wide ranging intracellular signaling cascades as evidenced by in-vitro and in-vivo research. It is worth describing that 'single-cell proteomics' analysis has further improved our understanding regarding intracellular signaling pathways frequently activated in cancer cells resistant to therapeutics and can provide biomarkers for cancer diagnosis and prognosis. Data obtained from preclinical studies will prove to be helpful for scientists to bridge basic and translational studies.

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Section: Introductionmentioning

confidence: 99%

Rutin mediated targeting of signaling machinery in cancer cells

et al. 2014

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“…Late apoptotic cell exhibited cytoplasmic blebbing and irregularity in shape apoptotic bodies. In the same way, Pupalialappacea, containing flavonoid rutin as the main component, caused the morphological changes in K562 cell by cell shrinkage and membrane blebbing when treated with the extract for 24 h (Ravi et al 2012).…”

Section: Discussionmentioning

confidence: 77%

Flavonoid Component Determination and Apoptotic Induction Evaluation of Houttuynia cordata Thunb Extract on Human Acute Leukemic Cells

Chanprasert¹

2017

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ABSTRAK Kejadian ketahanan dadah masa kini dan kesan samping beberapa dadah alopati telah meningkatkan penekanan ke atas penggunaan bahan tumbuhan sebagai sumber perubatan ke atas pelbagai penyakit termasuk leukemia. Houttuynia cordata Thunb (H.cordata) ialah tumbuhan setempat di utara Thailand yang dikenali sebagai & Health Dec 2017;12(2): 193-201 Boonyawee N. et al. for reducing the treatment side effects are significant and needed (Russo et al. 2011). Currently, herbal and natural product compounds are used as alternative medicine. Houttuynia cordata Thunb or Plucao in Thai, is in the Saururaceae family, and mostly found in Northern of Thailand and Asia. It has many bioactivities including anti-inflammation, antioxidative, anti-diabetes and anticancer ( ABSTRACTDevelopment of resistance to currently used drugs and side effects of several allopathic drugs have led to increased emphasis on plant materials uses as a source of medicines for a wide variety of human illnesses including leukemia. Houttuynia cordata Thunb (H.cordata), a Northern Thailand local plant and commonly known as Plucao, has various biological activities such as anti-inflammatory, anti-cancer and anti-leukemic activities. We aimed to determine active flavonoid components of H.cordata and to investigate the effect of H.cordata ethanolic extract on apoptotic induction on human acute lymphoblastic leukemia cells. In this study, we found that H.cordata ethanolic extract had total flavonoid of 231.21 ± 4.19 mg QE/g dried H.cordata. The extract analyzed by quantitative LC-MS consists of several flavonoid components including hyperin 6.35 ± 0.41, quercetin 0.34 ± 0.02, isoquercetin 1.10 ± 0.03, and rutin 0.88 ± 0.04 (%w/w). The cytotoxicity results showed dose dependent decrease in growth of Jurkat leukemic cells. Blebbing pattern of cell apoptosis was found in cells treated with H.cordata ethanolic extract for 24 and 48 hrs. Moreover, we found that the extract could substantially induce Jurkat cell death through apoptosis at both 12 and 24 hrs. In conclusion, these results indicated that H.cordata ethanolic extract which is composed of several flavonoids, possesses anti-leukemic activity through apoptotic induction in Jurkat leukemia cells.

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“…A wide variety of human disorders is currently being treated with the use of plant materials due to their decreased toxicity levels, cost-effectiveness as well as minimized side effects in order to avoid drug resistance caused by pharmacological agents [61][62][63].…”

Section: Effects Of Phytomedicinal Plants On Erectile Dysfunctionmentioning

confidence: 99%

“…Plants and herbs are persistently being studied for the identification of novel therapeutic agents. Among the 250,000 higher plant species on earth, more than 80,000 plants have medicinal values [62]. Herbal medicine is still the mainstay of about 75-80% of the global population, mainly in developing countries, for primary health care because of better cultural acceptability, better compatibility with the human body and lesser side effects.…”

Section: Effects Of Phytomedicinal Plants On Erectile Dysfunctionmentioning

confidence: 99%

Potentials of Phytotherapeutic Treatment of Erectile Dysfunction

Aboua¹,

Manirafasha²,

Mosito³

et al. 2014

Antioxidant-Antidiabetic Agents and Human Health

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Additional information is available at the end of the chapter http://dx.doi.org/10.5772/57174 . IntroductionErectile dysfunction ED or male impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis [ ]. There are various underlying causes, such as a compromised cardiovascular system and diseases such as diabetes and chronic kidney disease CKD , many of which are medically treatable. The causes of erectile dysfunction may be physiological or psychological [ ]. Sexual function includes libido, penile erection, ejaculation, and orgasm. While each of these parameters may be of concern to an individual patient, the vast majority of men complain of ED. Testosterone deficiency frequently is associated with decreased libido and ED. ED is a clinical problem that is underdiagnosed, under-evaluated, and under-treated. The prevalence of ED increases with age, and it is associated with multiple medical conditions including diabetes, hypertension, and heart disease that also increase with age. ED is a highly prevalent and often underreported condition. The prevalence of ED varies in different countries and approximately million men worldwide are estimated to be affected with ED. More than half of US men between the ages of and years are estimated to have ED. The worldwide ED prevalence in men with diabetes ranges from % to % and it is estimated that the prevalence of ED will double in the next years [ ]. There is a strong link between ED and atherosclerotic disease due to the fact that they share similar risk factors. In a study where patients referred for myocardial perfusion single-photon emission computed tomography were screened for ED with a questionnaire, it was found out that . % of the patients had ED. Patients with ED showed more severe coronary heart disease. In diabetic patients, ED has been shown to predict silent coronary artery disease, and in asymptomatic men without cardiovascular risk factors or

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Anticancer activity of Pupalia lappacea on chronic myeloid leukemia K562 cells

Cited by 21 publications

References 31 publications

Rutin mediated targeting of signaling machinery in cancer cells

Rutin mediated targeting of signaling machinery in cancer cells

Flavonoid Component Determination and Apoptotic Induction Evaluation of Houttuynia cordata Thunb Extract on Human Acute Leukemic Cells

Potentials of Phytotherapeutic Treatment of Erectile Dysfunction

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