Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells

Castro-Aceituno, Verónica; Ahn, Sungeun; Simu, Shakina Yesmin; Singh, Priyanka; Mathiyalagan, Ramya; Lee, Hyun A.; Yang, Deok Chun

doi:10.1016/j.biopha.2016.09.016

Cited by 131 publications

(64 citation statements)

References 39 publications

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“…A report by Jeyaraj et al () showed in vitro cytotoxicity of biogenic AgNPs against MCF‐7 (human breast cancer) cells and similar work by Jinu et al () reported AgNPs/ Cineraria prosposis leaf extract, led to the 50% death of MCF7. Other literature refers to the anticancer activity of AgNPs (Castro‐Aceituno et al, ; Datta, Chaudhuri, Malik, & Bandyopadhyay, ; Moulton et al, ; Venkatesan, Subramanian, Tumala, & Vellaichamy, ; Venugopal et al, ).…”

Section: Beneficial Effects Of Silver Nanoparticlesmentioning

confidence: 99%

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

Flores-López

Espinoza-Gómez

Somanathan

2018

J of Applied Toxicology

211

110

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The industry of nanotechnology has had a rapid development in the last decades. In particular, silver nanoparticles (AgNPs) have unique properties so they can be used in different industrial applications, mainly in areas such as electronics, environment, medicine, biosensors and biotechnology; as well as household and healthcare-related products, like cosmetics, due to their antimicrobial properties. These beneficial effects are also offset by the higher chemical reactivity of these NPs due to their surface area to volume ratio, leading to the increased formation of reactive oxygen species (ROS) within cells. AgNPs, however, have a dark side: they increase the formation of reactive oxygen species (ROS). With increased human exposure to AgNPs, the risk and safety standards have attracted much attention. This review highlights the beneficial and toxicological effects of AgNPs in terms of cytotoxicity and genotoxicity.

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Section: Beneficial Effects Of Silver Nanoparticlesmentioning

confidence: 99%

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

Flores-López

Espinoza-Gómez

Somanathan

2018

J of Applied Toxicology

211

110

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“…After treatment, the cells were stained with Hoechst 33258 solution at 2 μg/mL for 20 minutes following our previous protocol. 31 Scale bar (10 μm) was added using ImageJ software.…”

Section: In Vitro Cell Culture and Cell Cytotoxicitymentioning

confidence: 99%

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies

Singh¹,

Kim²,

Singh³

et al. 2017

IJN

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The present study investigates a simple and convenient one-step procedure for the preparation of bovine serum albumin (BSA)-Rh2 nanoparticles (NPs) at room temperature. In this work, ginsenoside Rh2 was entrapped within the BSA protein to form BSA-Rh2 NPs to enhance the aqueous solubility, stability, and therapeutic efficacy of Rh2. The physiochemical characterization by high-performance liquid chromatography, nuclear magnetic resonance, Fourier transform infrared spectroscopy, field emission transmission electron microscopy, dynamic light scattering, and thermogravimetric analysis confirmed that the prepared BSA-Rh2 NPs were spherical, highly monodispersed, and stable in aqueous systems. In addition, the stability of NPs in terms of different time intervals, pHs, and temperatures (20°C–700°C) was analyzed. The results obtained with different pHs showed that the synthesized BSA-Rh2 NPs were stable in the physiological buffer (pH 7.4) for up to 8 days, but degraded under acidic conditions (pH 5.0) representing the pH inside tumor cells. Furthermore, comparative analysis of the water solubility of BSA-Rh2 NPs and standard Rh2 showed that the BSA nanocarrier enhanced the water solubility of Rh2. Moreover, in vitro cytotoxicity assays including cell viability assays and morphological analyses revealed that Rh2-entrapped BSA NPs, unlike the free Rh2, demonstrated better in vitro cell viability in HaCaT skin cell lines and that BSA enhanced the anticancer effect of Rh2 in A549 lung cell and HT29 colon cancer cell lines. Additionally, anti-inflammatory assay of BSA-Rh2 NPs and standard Rh2 performed using RAW264.7 cells revealed decreased lipopolysaccharide-induced nitric oxide production by BSA-Rh2 NPs. Collectively, the present study suggests that BSA can significantly enhance the therapeutic behavior of Rh2 by improving its solubility and stability in aqueous systems, and hence, BSA-Rh2 NPs may potentially be used as a ginsenoside delivery vehicle in cancer and inflammatory cell lines.

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“…A key point in anticancer therapy is to have drugs or molecules that are highly selective to kill cancer cells. In the literature there are green silver nanoparticles with anticancer activity but their cytotoxic effects have not been evaluated in normal cells [21,30,33,37,39,42], others show that there is little selectivity for cancer cells [14,34] and other studies show encouraging anticancer activity due to a better degree of selectivity [32,35,36,40,41,43,45]. An advantage of the use of medicinal plant extracts is the opportunity to be able to functionalize silver nanoparticles to enhance their anticancer effect and improve their specificity of action on cancer cells without affecting nontumor cells; this represents a challenge for scientists.…”

Section: Anticancer Activitymentioning

confidence: 99%

Green Silver Nanoparticles: Novel Therapeutic Potential for Cancer and Microbial Infections

Ortiz¹

2017

JNMR

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The nanomedicine is opening borders by designing and testing both novel devices for clinical diagnosis and new therapies based on chemical nanostructures that exert their direct biological action or acting as pharmacological carriers. The development of new eco-friendly chemical synthesis methods opened a field of opportunity for nanomedicine and in the last years a great number of metallic nanoparticles have been synthesized through green chemical synthesis using natural plant extracts (leaf, stem, peel, bark, fruits). This review it shows an overview of the current status with silver nanoparticles synthesized by green chemical methods regarding their therapeutic potential for use in the treatment of microbial infections and cancer. The analysis carried out in recent publications shows that green silver nanoparticles have high antimicrobial activity (antibacterial, antifungal and antiviral) which can be enhanced with the addition of functional groups contained in the natural extracts used during the synthesis. In addition, there are many studies in different types of cancer that show the anticancer activity of green silver nanoparticles. This study shows that green synthesis has improved the selectivity of biological action and the biocompatibility of silver nanoparticles, these results are encouraging for treatment of cancer and microbial infections in humans.

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Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells

Cited by 131 publications

References 39 publications

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies

Green Silver Nanoparticles: Novel Therapeutic Potential for Cancer and Microbial Infections

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