Anticancer and Antibacterial Properties of Verthemia Iphionides Essential Oil /Silver Nanoparticles

Cancer is a major public health problem worldwide, and it is one of the leading cause of morbidity globally. 1-3 According to the international agency for research on cancer (IARC), there were 8.2 million cancer death worldwide in 2012, and by 2030 this burden is expected to grow to reach 13 million cancer death, 4 cancer cells are characterized by the unchecked division and survival of abnormal cells. 5 Therefore, there are ceaseless effort to search for new anticancer agents, since the chemotherapy might damage the normal cells while killing the cancer cell, which could lead to unfavourable side effect. 6,7 Herbs are considered as alternative source for treatment since they have fewer side effects and less cost. In the developing countries, and Jordan in particular, a large portion of the population relies on different herbal natural plants such as S. palaestina, O. dayi and B. chrysogonum, for their primary healthcare as antioxidant, antiinflammatory as well as in the treatment of cancer. 8-10 Herbal natural plants that are used in traditional medicine have a wide range of compounds; which can be used to treat infectious and chronic diseases. 11

Section: In Vitro Cytotoxicity Of Ethanolic Extracts Of Plants On T47mentioning

confidence: 99%

Section: In Vitro Cytotoxicity Of Ethanolic Extracts Of Plants On T47mentioning

confidence: 99%

Evaluation of Cytotoxic, Antioxidant and Antibacterial Activities of Origanum dayi, Salvia palaestina and Bongardia chrysogonum Plants Growing Wild in Jordan

2021

“…The test was done in duplicate and the cytotoxic effect was observed daily up to 72 hr of cultivation. 28,29 Changes in cell shape morphology including loss of monolayer, rounding, and shrinking was considered signs of cytotoxic effect of the tested samples under microscopy. Cultures of cell line without tested extract was used as a negative control.…”

Section: Culturing Of Cell Linesmentioning

confidence: 99%

Evaluation of Anti-inflammatory Activity of Methanol Extract of Rhus coriaria L. in Diabetic Rats

2021

commonly known as Sumac in the Mediterranean countries. It is used as a traditional spice due to its souring taste. 11 It is also used in folk medicine in Jordan as an astringent and anti-inflammatory agent. 12 It has several pharmacological activities including antimicrobial, antidiabetic, hepatoprotective, hypoglycemic, and DNA protective effect .13, 14 Several studies have demonstrated that the extract of Rhus species is a rich source of bioflavonoids, 15,16 hydrolyzable tannins, and gallotannins. 17 Moreover, in order to realize the dietary value of R. coriaria, its mineral contents, as well as the physical and chemical properties of gallotannins and flavonoid isomers in its fruits, were characterized. 18,19 Additionally, other studies showed that R. coriaria extracts have a high potential for wound healing activity in rats and have significant therapeutic activity against dyslipidemia, lipid peroxidation, and hyperglycemia in type 2 diabetic rats. 20 The present study evaluated the efficacy of R. coriaria methanol extract against carrageenan-induced paw oedema in an experimental diabetic rat model. Materials and Methods Collection of plant samplesFruits of R. coriaria were collected in August 2020 from theAjloun region north of Jordan and were identified and authenticated by Prof.

“…The test was done in duplicate and the cytotoxic effect was observed daily up to 72 hr of cultivation. 37,38 Changes in cell shape morphology including loss of monolayer, rounding, and shrinking was considered signs of cytotoxic effect of the tested samples under microscopy. Cultures of cell line without tested extract was implemented as negative controls.…”

Section: Culturing Of Cell Linesmentioning

confidence: 99%

Inhibitory Effects of Some Jordanian Medicinal Plants on In Vitro Viability of Protoscolices of Hydatid Cysts

2021

The common scolicidal agents used for the immobilization of protoscolices of hydatid cyst are mostly associated with side effects. The purpose of the current study was to investigate the methanol extracts of Ruta graveolens, Peganum harmala L. and seeds of Citrullus colocynthis L effects on hydatid cysts. The protoscolices were collected from hydatid cyst-infected sheep and goats and subjected to various concentrations of methanol extracts of the three plants (10, 20, 30 and 40 mg/mL) at different exposure times in vitro. Albendazole (ABZ) was used as a control. R. graveolens extract (40 mg/mL) killed 100% of the protoscolices in 75 minutes (1.25 hour) while the other concentrations (10, 20, 30 mg/mL) led to 100% mortality of the protoscolices at the maximum period of 12 hours, after treatment. Whereas, a 21% and maximum scolicidal effect (95%) were obtained using 20 mg/mL ABZ as control after 2 and 24-hour exposure period, respectively. The highest deadly effects obtained from P. Harmala and C. colocynthis extracts were 50 and 15%, respectively, using maximum concentrations (40 mg/mL), after 24 hours of treatment. Moreover, various concentrations of the R. graveolens extracts were very superior (P < 0.05) to the two plants and ABZ as control. The anti-fibroblast study showed that the use of 100 mg/mL of R. graveolens extract resulted in extremely low cytotoxicity with IC50 values of 65.78 mg/mL. Thus, the significant effects of this extract on the protoscolices reveal a new antihydatic activity using R. graveolens as a source of scolicidal agents.