2022
DOI: 10.12688/f1000research.128048.1
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Anticancer and antiretroviral activities of methanolic extract from Theobroma cacao L pod husk: focusing on the ethyl acetate partition

Abstract: Background: Many researchers have paid attention to Theobroma cocoa pod husk for its bioactive phytoconstituents which have several medicinal benefits. Herein, we aim to evaluate the methanolic extract from T. cocoa pod husk and its partitions for their anticancer and antiretroviral activities. Methods: The T. cocoa pod husk was macerated using methanol, and then sequentially partitioned with n-hexane and ethyl acetate. MCF-7 and HeLa cells were used to assess the anticancer activities, while the simian retrov… Show more

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Cited by 3 publications
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“…Theobroma cacao extract (TCEA) exhibited weak cytotoxicity against HeLa cells and moderate to MCF-7 cells. Additionally, the ethyl acetate extract with a concentration of 125 μg/mL demonstrated higher anti-SRV-2 activity than 25 μg/mL of lamivudine [17]. In this study, TCM extract was extracted with acetone to obtain Theobroma cacao acetone (TCA) extract.…”
Section: Introductionmentioning
confidence: 99%
“…Theobroma cacao extract (TCEA) exhibited weak cytotoxicity against HeLa cells and moderate to MCF-7 cells. Additionally, the ethyl acetate extract with a concentration of 125 μg/mL demonstrated higher anti-SRV-2 activity than 25 μg/mL of lamivudine [17]. In this study, TCM extract was extracted with acetone to obtain Theobroma cacao acetone (TCA) extract.…”
Section: Introductionmentioning
confidence: 99%