Anticancer and apoptosis-inducing effects of &lt;i&gt;Moringa concanensis&lt;/i&gt; using hepG2 cell lines

Balamurugan, V.; Balakrishnan, V.; Robinson, J. Philip; Ramakrishnan, Muthannan Andavar

doi:10.3329/bjp.v9i4.20481

Cited by 15 publications

(13 citation statements)

References 32 publications

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“…Crude plant extracts are screened on cell culture, to determine their efficiency as a potential alternate drug and also to check their efficiency in clinical application as suggested by Balamurugan et al (2014). Plants are primary resources for antioxidants like carotenes, phenolic acids, etc., the phytochemical analysis Tecoma stans revealed that the plant has alkaloids, steroids, glycosides and carbohydrates as suggested by (Prajapati, Patel, 2010).…”

Section: Resultsmentioning

confidence: 99%

“…An extensively used treatment for cancer is chemotherapy and one of the major drawbacks is the toxicity that is caused to the normal cells due to the inability of the chemical drugs to differentiate between normal and cancerous cells (Balamurugan et al, 2014). Traditional medicines have been tested and researched upon to obtain an effective drug against cancer.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549)

Robinson¹,

Kumaresan²,

Subbaiya³

et al. 2017

Braz. J. Pharm. Sci.

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Human have been constantly using plants and plant products to overcome many diseases. The antioxidant property of the plant sources is studied to obtain an efficacious drug against cancer. The objectives of the present study is to evaluate the antioxidant and cytotoxic activity of the Tecoma stans extracts against lung cancer cell line in comparison with vincristine drug. The antioxidant activity was studied using the standard DPPH assay and the cytotoxic activity using MTT assay. DPPH assay results show that methanolic extract of T. stans in higher concentration show better antioxidant potential than the standard L-ascorbic acid. They exhibited strong antioxidant potential at 20 µg/mL concentration. The absorbance at 517 nm showed that in the range of 0.201-0.0203 compared to that of absorbance of ascorbic acid at 0.023.Cytotoxic activity was studied using MTT assay which showed that the increase in concentration of extract increases the cell death. At 100µg/mL concentration there is an increased cytotoxic activity, i.e., 99% of cell inhibition. The results of antioxidant and anticancerous activity may be positively correlated.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549)

Robinson¹,

Kumaresan²,

Subbaiya³

et al. 2017

Braz. J. Pharm. Sci.

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“…Several reports show that plant crude extracts replicate at tumor sites under hypoxic conditions and stimulate the host immune response and gene expression and leads to the inhibition of tumor growth [21]. In this research, C. gynandra a common medicinal plant used in the treatment of tumor was selected and evaluated for its cytotoxic potential employing in vitro methods.…”

Section: Resultsmentioning

confidence: 99%

Gas Chromatography-Mass Spectrometry Analysis, in Vitro Cytotoxic and Antioxidant Efficacy Studies on Cleome Gynandra L. (Leaves): A Traditional Drug Source

Saravanan

Brindha

Narayanan

et al. 2017

Asian J Pharm Clin Res

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Objective: This study was aimed to assess the phytoconstituents, cytotoxic, and antioxidant efficacy of ethyl extract of Cleome gynandra leaves.Methods: Qualitative phytochemical analysis with different solvent extracts was performed. Quantitative and gas chromatography-mass spectrometry (GC-MS) analysis of the extract was performed with ethyl acetate extract. The cytotoxic effect of the ethyl acetate extract was determined by 3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide (MTT) assay on Michigan Cancer Foundation-7 (MCF-7) cells using taxol as standard and free radical scavenging ability using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Results:Leaves extracts with different solvents revealed the presence of alkaloids, cardiac glycosides, flavonoids, phenols, and tannins. GC-MS analysis of ethyl acetate of the plant leaves showed the presence of n-hexadecanoic acid. The IC 50 value of the ethyl acetate extract was found to be 90.2 μg/ml on MCF-7 cell line, and the extract was found to possess significant DPPH free radical scavenging activity. Conclusion:From the results, we conclude that the C. gynandra extract possesses antioxidant and antiproliferating activity against MCF-7 cells.

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“…Nimmo is one of the Indian medicinal plants belongs to the family of Moringaceae, used to treat various human diseases [5][6][7][8], M. concanensis Nimmo plant have confirmed anti-inflammatory [7,9], anticancer [10], analgesic [9], anti-pyretic [7], anti-implantation [11], anti-convulsant [12], anti-microbial anti-fungal [13] and antihyperglycemic activity [14]. To the best of our knowledge, Moringa concanensis Nimmo leaves extract have not been investigated for phytochemical profiles, free radical scavenging, and in vivo simulated in vitro antioxidant properties.…”

Section: Concanensismentioning

confidence: 99%

Evaluation of Free Radical Screening and Antioxidant Potential of Moringa Concanensis Nimmo-a Medicinal Plant Used in Indian Traditional Medication System

Balakrishnan

Krishnasamy

2018

Int J Pharm Pharm Sci

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Objective: We aimed to investigate the free radical scavenging, antioxidant and hepatoprotective potential of M. concanensis Nimmo leaves.Methods: Free radical scavenging activity was evaluated by employing various accepted in vitro systems, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), hydroxyl (OH) and nitric oxide (NO) radical. Antioxidant potential of M. concanensis Nimmo extract was assessed against H2O2 in goat liver by determination of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glucose-6-phosphatase dehydrogenase (G-6-PDH), total reduced glutathione (GSH), vitamin C, vitamin E activity, and lipid peroxidation (LPO).Results: Results showed that the amount of plant extract of M. concanensis Nimmo required to scavenge 50% of the DPPH radicals was 401.80 μg/ml, ABTS radical was 353.14 μg/ml, OH radical was 433.71 μg/ml and NO radical was 371.24 μg/ml. Also, the pre-treatment of ethanolic extract of M. concanensis Nimmo leaves in goat liver showed a significant protection against H2O2 induced oxidative stress by retaining of antioxidants of SOD (4.76±0.25), CAT (26.81±0.25), GPx (6.41±0.34), GST (2.31±0.10), G-6-PDH (0.84±0.02), GSH (37.30±1.12), vitamin C (3.01±0.07), vitamin E (14.43±0.45) within normal range.Conclusion: In conclusion, promising free radical scavenging, the antioxidant activity of M. concanensis Nimmo leaves can be able to treat various diseases caused by free radicals.

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Anticancer and apoptosis-inducing effects of <i>Moringa concanensis</i> using hepG2 cell lines

Cited by 15 publications

References 32 publications

Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549)

Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549)

Gas Chromatography-Mass Spectrometry Analysis, in Vitro Cytotoxic and Antioxidant Efficacy Studies on Cleome Gynandra L. (Leaves): A Traditional Drug Source

Evaluation of Free Radical Screening and Antioxidant Potential of Moringa Concanensis Nimmo-a Medicinal Plant Used in Indian Traditional Medication System

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