Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice

Liu, Jun; Zhang, Lihua; Ren, Yanling; Gao, Yanli; Li, Kang; Qiao, Qing

doi:10.1016/j.ijbiomac.2014.05.014

Cited by 67 publications

(51 citation statements)

References 31 publications

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“…These results were different from the other known polysaccharides from Ornithogalum caudatum [22], Chlorella pyrenoidosa [23], Portulaca oleracea L. [24] and G. pentaphyllum [25], all of which could directly inhibit the proliferation of cancer in vitro. However, Our result is in agreement with many other findings.…”

Section: Inhibition Of Tumor Cell Proliferation In Vitrocontrasting

confidence: 78%

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Chen

Huang

Cui

et al. 2015

International Journal of Biological Macromolecules

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Section: Inhibition Of Tumor Cell Proliferation In Vitrocontrasting

confidence: 78%

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Chen

Huang

Cui

et al. 2015

International Journal of Biological Macromolecules

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“…Inflammatory and immunity cytokines play a pivotal role in a wide variety of human cancer, including colorectal cancer [17,19]. The levels of IL-1α, IL-1β, IL-6, IL-8, G-CSF and GM-CSF were significantly decreased in the small intestine and colon of genkwanin-treated groups than those in the model group (P b 0.05 or P b 0.01) (Fig.…”

Section: Effects Of Genkwanin On the Levels Of Inflammatory And Immunmentioning

confidence: 89%

Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC Min/+ mice

Wang

Song

et al. 2015

International Immunopharmacology

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“…Accumulating evidence suggests that natural agents could open new avenues for the successful treatment of cancers, especially by combining with conventional therapeutics [6]. Natural agents have been and continued to be important sources of anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

Wang

Lei

et al. 2016

Cell Physiol Biochem

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Background/Aims: Osteosarcoma is the second highest cause of cancer-related death in children and adolescents. Majority of osteosarcoma patients (90%) show metastasis. Previous reports revealed that osthole showed antitumor activities via induction of apoptosis and inhibition of proliferation. However, the potential effects and detailed molecular mechanisms involved remained unclear. Methods: Cell viability was analyzed by MTT assay in osteosarcoma cell lines MG-63 and SAOS-2. Cell cycle was detected by flow cytometry. The effects of migration and invasion were evaluated by wound healing assay and transwell assays. Moreover, the level of proteins expression was determined by Western blot. Results: The cell viability of MG63 and SAOS-2 were markedly inhibited by osthole in a dose- and time-dependent manner. Cell cycle was arrested and the ability of migration and invasion was obviously reduced when cells were exposed to osthole. Moreover, enzymes involved in PTEN/Akt pathway were regulated such as PTEN and p-Akt proteins. Furthermore, osthole inhibited the tumor growth in vivo. Conclusion: Our study unraveled, for the first time, the ability of osthole to suppress osteosarcoma and elucidated the regulation of PTEN/Akt pathway as a signaling mechanism for the anti-tumor action of osthole. These findings indicate that osthole may represent a novel therapeutic strategy in the treatment of osteosarcoma.

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Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice

Cited by 67 publications

References 31 publications

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC Min/+ mice

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

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