Anticancer, Antiproliferative, Lysosomal and Lactate Dehydrogenase Inhibitory Effects of Fruit Extracts from Sumac (Rhus coriaria L.) on Human Lung Cancer Cells

Gezici, Sevgi

doi:10.5505/aot.2019.09326

Cited by 12 publications

(13 citation statements)

References 17 publications

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“…By now, anticancer, antiproliferative, anticholinesterase, antityrosinase, antioxidant, and other biological activities of numerous medicinal and aromatic plants (MAPs) and secondary metabolites isolated from MAPs were analysed in our laboratory (Akgunlu et al, 2016;Sekeroglu et al, 2017;Gezici et al, 2017;Belkhodja et al, 2017;Karik et al, 2018;Gundogdu et al, 2018;Senol et al, 2018;Gezici, 2018;Das et al, 2019;Shida et al, 2019;Gezici and Sekeroglu, 2019a;Gezici and Sekeroglu, 2019b;Gezici, 2019a;Gezici 2019b;Gezici, 2019, Sekeroglu et al, 2019 in press). Take into consideration our ongoing projects, evaluation cancer protective potentials against human cancer cells, investigating neuroprotective activities through enzyme inhibitions on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and TYR (tyrosinase) enzymes, along with determination of antioxidant capacities of extracts obtained from red hulls, kernels and oleo-gum resins of Pistachio (P. vera L.) are the main objectives of the presented research.…”

Section: Introductionmentioning

confidence: 99%

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Gezici¹

2019

International Journal of Agriculture Environment and Food Sciences

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This research was performed to assess cancer prevention and neuroprotective capacities of different parts of Pistachio (Pistachio vera L.). Red hulls, kernels and oleo-gum resins of Pistachio were extracted with methanol-MeOH and distilled water-dH 2 O, and subjected to in vitro biological assays varying from 100 to 1000 μg mL −1 concentrations. Their anticancer activities were evaluated against A549, MCF-7, and HeLa human cancer cells. Neuroprotective activities of the extracts were tested through enzyme inhibition on AChE, BChE, and TYR, which are closely related to pathogenesis of neurobiological disorders, particularly Alzheimer's and Parkinson's diseases. Due to cancer and neurodegenerative diseases are associated with oxidative damage, the extracts were analyzed for their antioxidant activities. With respect to free radical scavenging activities of the extracts, red hull extracts were found as the most potent ones both DPPH (67.95±1.13 to 80.55±0.12%) and ABTS (86.92±0.10 to 92.04±1.06%) radicals. The highest anticancer activity were determined in MeOH and dH 2 O extracts obtained from oleo-gum resin against HeLa cells (IC 50 = 18.50±0.85 and 28.97±0.08 µg mL-1 , p< 0.01, respectively), whilst dH 2 O-kernel extract was found to have the weakest anticancer activity towards A549 cells (IC 50 = 268.66±1.02 µg mL-1 , p< 0.01). Neuroprotective potentials on AChE and BChE enzymes were resulted in the superiority of dH 2 O-red hull extract was exerted the highest inhibition on AChE and BChE enzymes with 81.50±0.08 and 62.96±1.01% inhibition, respectively. However, dH 2 O extract from oleo-gum resin showed the highest inhibitory effect on TYR enzyme (58.16±0.18% inhibition). P. vera is of valuable nutritional source for human diet. Other than kernel parts used as food, waste parts like red hulls and oleo-gum resins have been proven as a potential pharmacological source. Consequently, this study reveals that non-food parts of Pistachio could be valuable source for pharmaceutical industry.

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Section: Introductionmentioning

confidence: 99%

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Gezici¹

2019

International Journal of Agriculture Environment and Food Sciences

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“…In order to determine anticancer activities of the turmeric extracts, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide) assay was performed as described by Mosmann (1983) 29 with minor modifications. 12,16 The absorbance was measured at 570 nm with a Thermo Lab systems 408 Multiskan multiplate spectrophotometer, and the dose response curve was used to generate the IC 50 (μg mL −1 ) values for each cells.…”

Section: 6mentioning

confidence: 99%

“…capacities by our research group. [12][13][14][15][16][17][18][19][20][21][22][23][24][25] The main purpose of these researches are to contribute to discover new and effective natural products for prevention and treatment of oxidative stress-related diseases and disorders. Take into consideration our previous researches on MAPs and plant-derived natural products, total polyphenolic contents, in vitro antioxidant effects, neuroprotective and anticancer activities of the extracts obtained from the rhizomes of C. longa L. were aimed to evaluate in the presented research.…”

Section: Introductionmentioning

confidence: 99%

A study on Turmeric (Curcuma longa L.): Multifunctional agents for the management of oxidative damage, neurodegeneration and cancer

Gezici

2019

Curr. Res. Pharm. Sci.

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The rhizome of Curcuma longa L, (turmeric, curcumin) has been widely used in therapeutic purposes for acne, heal wound, prevent skin damage, reduce cholesterol, treat diabetes, and control blood pressure. From this point of view, this research was aimed to investigate its biological properties including antioxidant, anticancer and neuroprotective properties of the turmeric rhizomes. The rhizomes of turmeric were extracted with methanol-MeOH and distilled water-dH 2 O, and subjected to various assays. Neuroprotective potentials of the extracts were tested through enzyme inhibitory assays on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which are closely linked to pathogenesis of Alzheimer's disease. Their anticancer activities were evaluated using MTT assay against A549, MCF-7, HeLa human cancer cells, and non-tumorous HUVECs. In vitro methods including 2,2diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing capacity (CUPRAC) were performed to reveal antioxidant capacities of the extracts. Total polyphenolic compositions of the extracts were also identified spectrophotometrically. The turmeric extracts were found to have rich polyphenolic quantities, particularly the MeOHextract possessed higher total polyphenolic contents than the dH 2 O-extract. The extracts demonstrated the remarkable inhibition on both of the cholinesterase enzymes even at the lowest concentration (100μg mL −1 ). Moreover, they showed higher enzyme inhibition against AChE, comparing with that of BChE enzyme. In general, a significant correlation was observed between the total antioxidant capacities and neuroprotective potentials of the extracts from turmeric rhizomes. As for the anticancer activity, the extracts were found as a natural anticancer agent with the IC 50 values ranged from 13.01±0.16 to 26.72±1.04 μg mL −1 . In the light of the findings of the presented research, it is clearly concluded that turmeric is an important natural source to fight oxidative stress related diseases, with its excellent cholinesterase-inhibiting properties; strong antioxidant capacities as well as remarkable anticancer activities.

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“…Meyveleri insan ve hayvan gıdası olarak kullanılan kermes meşesinin farklı bitki kısımları yüzyıllardır çeşitli hastalıkların tedavisinde halk ilacı olarak kullanılmakta, bitkinin meyvelerinin; sahip olduğu antimikrobiyal, antiülser, antihelmintik, antiinflamatuvar ve antioksidan aktivitelerinden dolayı, Anadolu Halk Hekimliğinde hemoroit, şeker hastalığı ve böbrek taşı rahatsızlıklarında kullanıldığı belirtilmektedir (Akcan ve ark., 2017; Sohretoglu ve ark., 2007). Çeşitli tıbbi ve etnobotanik kullanımlarının yanı sıra palamut adı verilen meşe meyveleri kavrulup öğütüldükten sonra farklı aroması ile kahve şeklinde de tüketilmektedir (Gezici ve Sekeroglu, 2019a Karik ve ark., 2018;Sekeroglu ve ark., 2018;Senol ve ark., 2018;Gezici, 2018Gezici, , 2019Gezici ve Sekeroglu, 2019a;2019b;Shida ve ark., 2019), meşe palamudunun (Q. coccifera L.) dış kabuk, külah ve iç kısımlarından elde edilen ekstraktların toplam polifenolik içerikleri, in vitro antioksidan kapasiteleri ve nöroprotektif aktiviteleri de önceki çalışmalarımızda tespit edilmiştir (Senol ve ark., 2018;Gezici ve Sekeroglu, 2019b Davis (1982) Türkiye Florası'na göre yapılmış olup; bitki materyali Biyoloji Bölümü Herbaryum'unda saklanmaktadır.…”

Section: Giri̇şunclassified

Anticancer, Antiproliferative and Lactate Dehydrogenase Enzyme Activities of Different Parts of Acorn (Quercus coccifera L.) against A549, MCF-7 and HeLa Human Cancer Cells

Gezici

2019

Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi

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Bu çalışmada, Meşe palamudunun (Q. coccifera) dış-kabuk, külah ve iç kısmından elde edilen özütlerin; A549, MCF-7, HeLa kanser hücreleri ve kanserli olmayan HUVEC hücrelerine karşı potansiyel antikanser, antiproliferatif ve nekrotik kapasiteleri araştırılmıştır. Analizler sonucunda, meşe palamudunun farklı kısımlarından elde edilen ekstrelerin en düşük konsantrasyonda dahi antikanser ve antiproliferatif etkiye sahip oldukları ortaya konulmuştur. Palamut meyvesinin külah kısmından elde edilen etanol özütleri, 5.04±0.02 ile 18.04±0.16 µg/mL arasında değişen IC50 değerleriyle, diğer kısımlarından elde edilen özütlerden daha yüksek antikanser aktivite göstermiştir. En yüksek oranda sitotoksik aktivite MCF-7 hücrelerine karşı gözlenirken; en düşük sitotoksik aktivite ise A549 hücrelerinde gözlenmiştir. Antikanser ve antiproliferatif aktivite sonuçlarının aksine, en yüksek LDH aktivitesi HeLa hücrelerinde belirlenmiştir. MTT ve tripan mavisi analiz sonuçlarıyla uyumlu olarak, en yüksek LDH salınım kapasitesi külah kısmından elde etanol özütlerinde saptanmıştır. Bu çalışma; meşe palamudunun, kanser hücrelerinde hücre büyümesini konsantrasyon ve zamana bağlı olarak engelleme potansiyeline sahip olduğunu ortaya koyan, özgün bir çalışmadır.

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Anticancer, Antiproliferative, Lysosomal and Lactate Dehydrogenase Inhibitory Effects of Fruit Extracts from Sumac (Rhus coriaria L.) on Human Lung Cancer Cells

Cited by 12 publications

References 17 publications

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

Cancer preventive and neuroprotective potentials of red hulls, kernels and oleo-gum resins from Pistachio

A study on Turmeric (Curcuma longa L.): Multifunctional agents for the management of oxidative damage, neurodegeneration and cancer

Anticancer, Antiproliferative and Lactate Dehydrogenase Enzyme Activities of Different Parts of Acorn (Quercus coccifera L.) against A549, MCF-7 and HeLa Human Cancer Cells

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