Anticancer cyclometalated complexes of platinum group metals and gold

Cutillas, Natalia; Yellol, Gorakh S.; Haro, Concepción de; Vicente, Consuelo; Rodrı́guez, Venancio; Ruiz, José

doi:10.1016/j.ccr.2013.03.024

Cited by 312 publications

(181 citation statements)

References 174 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…Gold(III) complexes, those are isoelectronic and isostructural to platinum(II) complexes, show promising antitumor activity (Sadler 1976;Ott 2009;Bindoli et al 2009;Cutillas et al 2013). Surprisingly, only a few reports exist in the literature describing the cytotoxic properties and the in vivo antitumor effects of gold(III) complexes (Buckley et al 1996;Calamai et al 1998;Cossu et al 1994).…”

Section: Introductionmentioning

confidence: 90%

Synthesis, characterization and theoretical calculations of (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride complexes: in vitro cytotoxic evaluations against human cancer cell lines

et al. 2015

View full text Add to dashboard Cite

The gold(III) complexes of the type (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride, [(DACH)Au(pn)]Cl3, [where DACH = cis-, trans-1,2- and S,S-1,2-diaminocyclohexane and pn = 1,3-diaminopropane] have been synthesized and characterized using various spectroscopic and analytical techniques including elemental analysis, UV-Vis and FTIR spectroscopy; solution as well as solid-state NMR measurements. The solid-state (13)C NMR shows that 1,2-diaminocyclohexane (1,2-DACH) and 1,3-diaminopropane (pn) are strongly bound to the gold(III) center via N donor atoms. The stability of the mixed diamine ligand gold(III) was checked by UV-Vis spectroscopy and NMR measurements. The molecular structure of compound 1 (containing cis-1,2-DACH) was determined by X-ray diffraction analysis. The structure of 1 consists of [(cis-DACH)Au(pn)](3+) complex ion and chloride counter ions. Each gold atom in the complex ion adopts a distorted square-planar geometry. The structural details and relative stabilities of the four possible isomers of the complexes were also estimated at the B3LYP/LANL2DZ level of theoretical calculations. The computational study demonstrates that trans- conformations are slightly more stable than the cis- conformations. The antiproliferative effects and cytotoxic properties of the mixed ligand gold(III) complexes were evaluated in vitro on human gastric SGC7901 and prostate PC3 cancer cells using MTT assay. The antiproliferative study of the gold(III) complexes on PC3 and SGC7901 cells indicate that complex 3 (containing 1S,2S-(+)-1,2-(DACH)) is the most effective antiproliferative agent. The IC50 data reveal that the in vitro cytotoxicity of complex 3 against SGC7901 cancer cells manifested similar and very pronounced cytotoxic effects with respect to cisplatin. Moreover, the electrochemical behavior, and the interaction of complex 3 with two well-known model proteins, namely, hen egg white lysozyme and bovine serum albumin is also reported.

show abstract

Section: Introductionmentioning

confidence: 90%

Synthesis, characterization and theoretical calculations of (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride complexes: in vitro cytotoxic evaluations against human cancer cell lines

et al. 2015

View full text Add to dashboard Cite

show abstract

“…[4][5][6] The antitumor activity of the rhodium(III) salt RhCl 3 ·xH 2 O, was first mentioned in 1953, more than a decade before the antitumor activity of a platinum complex was reported. 7,8 The main drawback of the metal complexes from the 9 th group of the Periodic Table is that they have shown inertness and only recently Rh III complexes have received increasing attention.…”

Section: -3mentioning

confidence: 99%

Synthesis and structures of a pincer-type rhodium(iii) complex: reactivity toward biomolecules

et al. 2016

View full text Add to dashboard Cite

with 22mer GG duplex DNA. In addition, a higher reactivity is achieved with a DNA duplex with a centrally located GG-sequence than with a 22GTG duplex DNA, in which the GG-sequence is separated by a T base. Furthermore, the interaction of this metal complex 1 with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) was examined by absorption (UV-Vis) and emission spectral studies (EthBr displacement studies). Overall, the studied complex exhibited good DNA and BSA interaction ability.

show abstract

“…[11][12][13][14] Pt compound, cisplatin (cis-diaminedichloroplatinum) is a well known anticancer agent although it has high possibilities of treatment associated side effects. 15 Similarly, another such noble metal, Pd is also well known for its catalytic properties in carbon-carbon and carbon-heteroatom coupling reactions. It is also used for synthesizing complex organic molecules.…”

Section: Introductionmentioning

confidence: 99%

Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities

Ghosh

Nitnavare

Dewle

et al. 2015

IJN

View full text Add to dashboard Cite

Medicinal plants serve as rich sources of diverse bioactive phytochemicals that might even take part in bioreduction and stabilization of phytogenic nanoparticles with immense therapeutic properties. Herein, we report for the first time the rapid efficient synthesis of novel platinum–palladium bimetallic nanoparticles (Pt–PdNPs) along with individual platinum (PtNPs) and palladium (PdNPs) nanoparticles using a medicinal plant, Dioscorea bulbifera tuber extract (DBTE). High-resolution transmission electron microscopy revealed monodispersed PtNPs of size 2–5 nm, while PdNPs and Pt–PdNPs between 10 and 25 nm. Energy dispersive spectroscopy analysis confirmed 30.88%±1.73% elemental Pt and 68.96%±1.48% elemental Pd in the bimetallic nanoparticles. Fourier transform infrared spectra indicated strong peaks at 3,373 cm −1 , attributed to hydroxyl group of polyphenolic compounds in DBTE that might play a key role in bioreduction in addition to the sharp peaks at 2,937, 1,647, 1,518, and 1,024 cm −1 , associated with C–H stretching, N–H bending in primary amines, N–O stretching in nitro group, and C–C stretch, respectively. Anticancer activity against HeLa cells showed that Pt–PdNPs exhibited more pronounced cell death of 74.25% compared to individual PtNPs (12.6%) or PdNPs (33.15%). Further, Pt–PdNPs showed an enhanced scavenging activity against 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and hydroxyl radicals.

show abstract

Anticancer cyclometalated complexes of platinum group metals and gold

Cited by 312 publications

References 174 publications

Synthesis, characterization and theoretical calculations of (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride complexes: in vitro cytotoxic evaluations against human cancer cell lines

Synthesis, characterization and theoretical calculations of (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride complexes: in vitro cytotoxic evaluations against human cancer cell lines

Synthesis and structures of a pincer-type rhodium(iii) complex: reactivity toward biomolecules

Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities

Contact Info

Product

Resources

About

Anticancer cyclometalated complexes of platinum group metals and gold

Cited by 312 publications

References 174 publications

Synthesis, characterization and theoretical calculations of (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride complexes: in vitro cytotoxic evaluations against human cancer cell lines

Synthesis, characterization and theoretical calculations of (1,2-diaminocyclohexane)(1,3-diaminopropane)gold(III) chloride complexes: in vitro cytotoxic evaluations against human cancer cell lines

Synthesis and structures of a pincer-type rhodium(iii) complex: reactivity toward biomolecules

Novel platinum&ndash;palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities

Contact Info

Product

Resources

About

Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities