Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity

Teiten, Marie-Hélène; Mack, Fabienne; Debbab, Abdessamad; Aly, Amal H.; Dicato, Mario; Proksch, Peter; Diederich, Marc

doi:10.1016/j.bmc.2013.04.024

Cited by 83 publications

(41 citation statements)

References 52 publications

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“…Later on its antitumor potential was linked to its pro‐apoptotic and anti‐invasive potential that occurs through the inhibition of NF‐ κ B transcriptional activity (Teiten et al . ).…”

Section: Resultsmentioning

confidence: 97%

“…Altersolanol A inhibits a broad panel of kinases which suggests that the inhibition may be a major mechanism for the cytotoxic activity of this compound (Debbab et al 2009). Later on its antitumor potential was linked to its pro-apoptotic and anti-invasive potential that occurs through the inhibition of NF-jB transcriptional activity (Teiten et al 2013).…”

Section: In Vitro Antitumor Activity Of Altersolanol a In A Panel Of mentioning

confidence: 99%

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Altersolanol A: a selective cytotoxic anthraquinone from a Phomopsis sp.

Prabhu

Verekar

Deshmukh

et al. 2015

Lett Appl Microbiol

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This study confirms the cytotoxic potential of Altersolanol A isolated from the endophyte Phomopsis sp. (PM0409092) of the plant Nyctanthes arbor-tristis. The compound exhibits in vitro cytotoxicity against 34 human cancer cell lines with mean IC50 (IC70) value of 0.005 μg ml(-1) (0.024 μg ml(-1)). This is an in-depth report of Altersolanol A against a panel of 34 human cancer cell lines and extends observations from previous studies indicating that Altersolanol A can be used for the development of chemotherapeutics. Altersolanol A, a kinase inhibitor, induces cell death by apoptosis through the cleavage of Caspase-3 and -9 and by decreased anti-apoptotic protein expression.

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Section: Resultsmentioning

confidence: 97%

Section: In Vitro Antitumor Activity Of Altersolanol a In A Panel Of mentioning

confidence: 99%

Altersolanol A: a selective cytotoxic anthraquinone from a Phomopsis sp.

Prabhu

Verekar

Deshmukh

et al. 2015

Lett Appl Microbiol

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show abstract

“…HRMS (ESI) 206.0,190.9,156.1,143.2,133.9,132.9,131.4,130.8,128.9,128.6,127.5,127.0,113.0,111.4,89.6,44.3,39.2,30.1,28.9,25.2. HRMS (ESI) 8, 191.6, 155.2, 143.5, 133.7, 131.2, 129.8, 129.2, 128.9, 128.5, 126.9, 121.5, 121.0, 120.1, 88.5, 44.4, 39.8, 30.1, 29.0, 25.3, 15. 7,191.4,160.7,158.1,143.3,133.7,131.1,128.8,128.5,128.0,124.5,122.2,106.8,96.5,89.7,55.5,44.8,38.8,30.2,29.0,25.3. HRMS (ESI) 8, 191.4, 154.6, 144.2, 143.4, 133.7, 131.1, 129.7, 128.8, 128.5, 126.9, 125.4, 121.1, 109.0, 89.0, 44.6, 39.6, 34.4, 31.8, 30.2, 29.0, 25.3 4, 191.4, 153.8, 151.1, 143.3, 137.3, 133.7, 131.4, 131.1, 128.8, 128.5, 127.9, 127.5, 126.9, 114.8, 111.9, 109.8, 89.1, 71.0, 44.5, 39.7, 30.2, 29.7, 29.0, 25.3 7, 191.6, 155.1, 143.3, 136.9, 133.6, 131.1, 129.0, 128.8, 128.5, 127.4, 126.9, 125.2, 110.9, 88.8, 44.8, 39.3, 30.2, 28.9, 25.4, 20.1, 19.4 133.6, 131.2, 130.4, 130.3, 129.3, 128.9, 128.5, 126.9, 122.0, 119.5, 88.5, 44.5, 39.8, 30.1, 29.0, 25.4, 20.8, 15. 198.0, 191.3, 156.9, 143.4, 136.5, 133.7, 133.5, 131....…”

Section: General Synthesis Proceduresmentioning

confidence: 98%

“…1, D) also display important biological or pharmaceutical properties, such as antibacterial, 6 anticancer, 7 and indanone derivatives have been proved to act as aceylcholinesterase inhibitors. 8 Especially, spiroindanone scaffolds are also known for their anti-mycobacterial properties, many of them have shown comparable or even better activities than some of the fist-line tuberculosis drugs (Fig.…”

Section: Introductionmentioning

confidence: 99%

One-pot reaction for the concise synthesis of spiro[benzofuran-2,2′-naphthalen]-1′-one derivatives

Liu

et al. 2014

Tetrahedron

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“…An intensive search for effective antimicrobial agents can be pursued by exploring new niches and habitats [2]. In recent past, endophytes represent a diverse group of microbes which inhabits in special and unusual environmental conditions, making them a potential source for new drugs for medicinal and agricultural use [3].…”

Section: Introductionmentioning

confidence: 99%

ASSESSMENT OF BIOACTIVE METABOLITES FROM THE ROOT ENDOPHYTE ISOLATED FROM CASUARINA JUNGHUHNIANA Miq.

Bose¹,

Gowrie²

2017

Asian J Pharm Clin Res

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Objective: Casuarina junghuhniana Miq. is a well-known multipurpose tree belonging to family Casuarinaceae. This tree has the ability to sustain in different edaphic and extreme environmental conditions. The root extract of this tree is a rich source of potential secondary metabolites. Therefore, the main objective of this study is to isolate fungal root endophyte from this tree and to determine its bioactive compound which can be utilized in agriculture and pharmaceutical industries.Methods: C. junghuhniana Miq. root samples were collected from the State Forestry Research Institute, Neyveli (Vridhachalam Research Range, Cuddalore District). Isolation of fungal endophyte was carried out using potato dextrose agar medium. The qualitative and quantitative phytochemicals screening and enzyme assays were carried out using standard procedures. Antimicrobial assay was tested against different pathogens using well diffusion method. Further, the phytochemicals in the root extract were evaluated using Fourier transform infrared (FTIR), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS) studies.Result: Among the isolated endophytes, the dominant isolate (CJN5) was identified as Aspergillus sp. which showed positive result in the production of industrially important enzymes, namely, cellulase, lipase, and amylase. The qualitative screening revealed the presence of various phytoconstituents. Total phenolic content of culture filtrate extract (CFE) (208.20±2 mg/g) was found higher than culture mycelium extract (CME) (165.5±3 mg/g). The total flavonoid content of CFE (25.95±2 mg/g) was also found higher than CME (3.59±2 mg/g) using respective standards. Antimicrobial activity showed maximum zone of inhibition against Pseudomonas aeruginosa (bacterial pathogen) (24±0.1 mm) and Fusarium oxysporum (fungal phytopathogen) (34±0.2 mm). FTIR analysis showed the presence of varied functional groups. HPLC study revealed the presence of gallic acid and salicylic acid. Several peaks were obtained in GC-MS analysis which indicates the presence of different secondary metabolites. Conclusion:Aspergillus sp, isolated from the root of C. junghuhniana Miq. is a promising source of bioactive compounds which can be utilized in agriculture and pharmaceutical industries.

show abstract

Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity

Cited by 83 publications

References 52 publications

Altersolanol A: a selective cytotoxic anthraquinone from a Phomopsis sp.

Altersolanol A: a selective cytotoxic anthraquinone from a Phomopsis sp.

One-pot reaction for the concise synthesis of spiro[benzofuran-2,2′-naphthalen]-1′-one derivatives

ASSESSMENT OF BIOACTIVE METABOLITES FROM THE ROOT ENDOPHYTE ISOLATED FROM CASUARINA JUNGHUHNIANA Miq.

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