Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells

Inada, Masahiro; Shindo, Mika; Kobayashi, K.; Sato, Akira; Yamamoto, Yohei; Akasaki, Yukio; Ichimura, Koichi; Tanuma, Sei Ichi

doi:10.1371/journal.pone.0216358

Cited by 46 publications

(59 citation statements)

References 27 publications

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“…[23,25] Recently, it has also been shown to harbor anti-cancerous properties by inhibiting GBM cell growth in mice models, making it an interesting adjunct in this setting. [17]…”

Section: Discussionmentioning

confidence: 99%

Symptomatic cerebral vasospasm in the setting of carmustine wafer placement for glioblastoma: A case presentation and review of literature

Khan¹,

Cirjan²,

Quadri³

et al. 2020

Surgical Neurology International

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Background: Gliadel placement in glioblastoma resection, particularly with concurrent chemoradiation, has demonstrated an improvement in survival. There have been several reported adverse effects, some of which lend to significantly increased morbidity and mortality. With only two other cases described in literature, cerebral vasospasm secondary to carmustine-impregnated wafers is an extremely rare side effect. Case Description: We report the case of a 51-year-old female who presented with the left lower limb paresis 8 days after high-grade glioma resection provoked by carmustine wafer placement. Conclusion: We urge surgeons to reconsider placement of carmustine wafers in nations where the surgical resection cavity includes exposed large cerebral vasculature. We also propose the early identification of this devastating complication in the postoperative period by maintaining a high clinical suspicion and prompt utilization of computed tomography and digital subtraction angiography in the management and treatment of these patients accordingly.

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“…[23,25] Recently, it has also been shown to harbor anti-cancerous properties by inhibiting GBM cell growth in mice models, making it an interesting adjunct in this setting. [17]…”

Section: Discussionmentioning

confidence: 99%

Symptomatic cerebral vasospasm in the setting of carmustine wafer placement for glioblastoma: A case presentation and review of literature

Khan¹,

Cirjan²,

Quadri³

et al. 2020

Surgical Neurology International

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“…Using RAGE-or dominant-negative RAGE-expressing HT1080 human fibrosarcoma cells, papaverine suppressed RAGE-dependent HT1080 human fibrosarcoma cell proliferation, migration, and invasion in a dose-dependent manner through a significant inhibition of RAGE-dependent NF-κB driven by HMGB1 [11] (Figure 3). Furthermore, papaverine downregulated HMGB1 and RAGE along with significant inhibition of cell proliferation in human glioblastoma (U87MG and T98G) cell lines [153]. Therefore, papaverine could inhibit RAGE and is considered to be a promising anticancer drug.…”

Section: Papaverinementioning

confidence: 99%

“…Papaverine, a non-narcotic opium alkaloid, is isolated from Papaver somniferum. Papaverine exhibited selective anticancer effects against several tumor cells [11,153]. An in vitro study was done to investigate the anti-RAGE effect of papaverine, optimized by the structure-based drug design system named conversion-to-small-molecules-through optimized-peptide strategy (COSMOS), in HT1080 human fibrosarcoma cells.…”

Section: Papaverinementioning

confidence: 99%

Role and Mechanisms of RAGE-Ligand Complexes and RAGE-Inhibitors in Cancer Progression

El‐Far

Sroga

Jaouni

et al. 2020

IJMS

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Interactions of the receptor for advanced glycation end product (RAGE) and its ligands in the context of their role in diabetes mellitus, inflammation, and carcinogenesis have been extensively investigated. This review focuses on the role of RAGE-ligands and anti-RAGE drugs capable of controlling cancer progression. Different studies have demonstrated interaction of RAGE with a diverse range of acidic (negatively charged) ligands such as advanced glycation end products (AGEs), high-mobility group box1 (HMGB1), and S100s, and their importance to cancer progression. Some RAGE-ligands displayed effects on anti- and pro-apoptotic proteins through upregulation of the phosphatidylinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), mitogen-activated protein kinases (MAPKs), matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF), and nuclear factor kappa B (NF-κB) pathways, while downregulating p53 in cancer progression. In addition, RAGE may undergo ligand-driven multimodal dimerization or oligomerization mediated through self-association of some of its subunits. We conclude our review by proposing possible future lines of study that could result in control of cancer progression through RAGE inhibition.

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“…Papaverine, another non-narcotic opium alkaloid with well-established antispasmodic activity, has shown some anti-tumor effects, but its potential has been a matter of controversy. As a high-mobility group box 1 protein (HMGB1)/receptor for advanced glycation end products (RAGEs) inhibitor, papaverine was able to suppress cell proliferation and cancer cell migration in human glioblastoma (GBM) [ 86 ]. These papaverine properties have been observed in other cell lines, but the mechanism of the effect can vary [ 87 - 89 ].…”

Section: The Role Of the Opioid System In Hemato-oncological Conditiomentioning

confidence: 99%

Impact of Opioid Use in Hematological Malignancies: Clinical, Immunological and Concomitant Aspects

Tregubenko

Zvonarev

2020

J Hematol

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Opioid agents play a unique role in pain and symptom management for cancer patients. Research shows that opiate use, especially when associated with underlying cancer, has significant effects on hematological parameters. These changes may lead to greater risk for immunosuppression, tumor growth and progression of metastatic processes. The aim of this review is to explore the effects of opiates on various metabolic and biological processes, as well as the hematopoietic system, especially in cancer patients. Our findings demonstrate that the tumor-promoting effects of opiates remain contradictory, as both growth-promoting and anti-tumor effects have been observed. However, available data suggest that opiates can facilitate the proliferation and migration of tumor cells, and understanding of this process on cancer treatment is tremendously important.

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Anticancer effects of a non-narcotic opium alkaloid medicine, papaverine, in human glioblastoma cells

Cited by 46 publications

References 27 publications

Symptomatic cerebral vasospasm in the setting of carmustine wafer placement for glioblastoma: A case presentation and review of literature

Symptomatic cerebral vasospasm in the setting of carmustine wafer placement for glioblastoma: A case presentation and review of literature

Role and Mechanisms of RAGE-Ligand Complexes and RAGE-Inhibitors in Cancer Progression

Impact of Opioid Use in Hematological Malignancies: Clinical, Immunological and Concomitant Aspects

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