Anticancer Evaluation of Amphipterygium adstringens

Amphipterygium adstringens (Schltdl.) Schiede ex Standl (Anacardiaceae): An Endemic Plant with Relevant Pharmacological Properties

“…A later study reported that the methanolic extract of the stem bark reduced tumor growth 54% in a mammary adenocarcinoma murine model. The antineoplastic activity was identified mainly in polar fractions (aqueous) and was related to glycosylated steroidal saponins [43]. It should be noted that an adverse effect of some fractions of low polarities (petroleum ether and chloroform) that stimulated tumor growth 57 to 113% [43] was also recorded.…”

“…The presence of saponins in the aqueous extract is suggested by the formation of foam when shaken vigorously (Figure 5c). However, only one steroidal saponin has been isolated, which, by comparison with a reference sample, was identified as sarsasapogenin, which is glycosylated with D-glucose and D-rhamnose residues [43]. The Mexican Herbal Pharmacopoeia mentions the use of 3α-hydroxymasticadienonic acid as a specific marker for A. adstringens [31].…”

“…Moreover, the HPLC (high-performance liquid chromatography) and GC/MS (gas chromatography/mass spectrometry) analysis of the ethanolic extract identified the presence of other compounds, such as catechins, cardanols, β-terpineol, catechol, naringenin, pinocembrin, and fatty acids [48]. Likewise, non-hydrolysable tannins with a catechol nucleus were identified [43].…”

“…It should be noted that an adverse effect of some fractions of low polarities (petroleum ether and chloroform) that stimulated tumor growth 57 to 113% [43] was also recorded. Finally, sarsapogenin (Figure 7) was identified (its glycosylated form contains D-glucose and D-rhamnose residues), but no studies were conducted to corroborate its antitumor activity individually [43].…”

Immunostimulating Effect of Aqueous Extract of <em>Amphypterygium Adstringens</em> on Immune Cellular Response in Immunosuppressed Mice

“…Active principles and extracts from bark have been shown to posses anti-ulcer (Navarrete et al, 1998(Navarrete et al, , 2005, anti-inflammatory (Navarrete et al, 2005; OviedoChávez et al, 2004) and antitumor properties. A methanol extract showed an anti-tumor effect in a murine mammary tumor model (González et al, 1962). Further, Makino et al (2004) showed growth inhibitory activity against leukemia cells (L-1210) of five tirucallane-type triterpenes were isolated along with nine known triterpenes from the bark of J. adstringens.…”