Anticancer mechanism of Pisangulin angulata through in silico and development as teaching material

Abstract

This study aims to reveal the anticancer mechanism of the bioactive compound of Pisangulin angulata and to assess the feasibility of that results as teaching material. This research includes descriptive explorations. In the first stage, an in silico analysis was performed by molecular docking method between physalin compounds and GLI1 protein. The second steps of this study aim to develop teaching materials based research using the Analysis, Reorganizing, Piloting Class, and Evaluating (ARPE models). Feasibility test was carried out by experts and practitioners. Think Pair Share was used in the pilot project. Student motivation and misconception were recorded using SMI and CRI instrument. This study reveals that physalin B has higher activities than controls. The type of chemical bond that is formed between GLI1 amino acids residues with physalin is hydrogen bonds and hydrophobic bonds. The visualization of the types of bonds in that molecular docking between GLI1 amino acid residues and physalin has a high degree of feasibility (89) and can be used to enrich Chemistry for Biology lectures. The visualization of these chemical bonds can increase learning motivation and can improve the understanding of the concept of chemical bonds.

Nephrotoxicity effect of Ginseng Bugis (Talinum paniculatum (Jacq) Gaertn) leaves ethanolic extract on creatinine, urea, and kidney histopathological features

“…In South Sulawesi province of Indonesia, the plant is called Ginseng Bugis (Emelda et al, 2020). The root is known to possess a tonic effect, and believed to have benefits to the body system (Santoso et al, 2016;Sulistiono et al, 2017). Ginseng leaves contain protein, magnesium, potassium, ascorbic acid, phenonugrlic, flavonoids, and iron, which provide beneficial effects (Moura et al, 2020;Menezes et al, 2021).…”

Lactagogue Activity of Aqueous Extract of Javanese Ginseng Leaves on Wistar Mice

“…4 Javanese ginseng (Talinum paniculatum Gaertn) is a succulent plant that originates from Indonesia. 5 Javanese Ginseng plants can be easily propagated and sometimes cultivated in pots and community gardens. Ginseng is an adaptogen; it provides overall balance by increasing the body's ability to heal.…”