Anticancer Potential of Brassinosteroids

Panibrat, Olesya V.; Жабинский, В. Н.; Хрипач, В. А.

doi:10.1007/978-981-13-6058-9_14

Cited by 6 publications

(9 citation statements)

References 59 publications

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“…Analysis of SAR of 22,23-dihydroxy derivatives of C-27 -C-29 steroids have revealed that the derivatives 2a-2d ( Figure 1) containing a Δ 2double bond in the A cycle obtain better cytotoxicity towards number of cancer cell lines. [11] It should be noted that similar compounds (in particular, secasterol 2a) were found in plants as biosynthetic precursors of BS with a complete set of functional groups. [12] Compounds 2a and 2b have demonstrated significant cytotoxic effects on MCF-7 breast cancer cell lines with IC 50 below 2 μM.…”

Section: Introductionmentioning

confidence: 91%

Biological Evaluation of a New Brassinosteroid: Antiproliferative Effects and Targeting Estrogen Receptor α Pathways

Scherbakov

Жабинский

Хрипач

et al. 2019

Chemistry & Biodiversity

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Brassinosteroids (BS), a class of plant‐specific steroid hormones, are considered as new potential anticancer agents for the treatment of tumors of different origin, including hormone‐dependent cancers. Effects of a synthetic brassinosteroid BS4 ((22R,23R,24R)‐22,23‐dihydroxy‐24‐methyl‐B‐homo‐7‐oxa‐5α‐cholest‐2‐en‐6‐one ((3aS,7aR,7bS,9aS,10R,12aS,12bS)‐10‐[(2S,3R,4R,5R)‐3,4‐dihydroxy‐5,6‐dimethylheptan‐2‐yl]‐7a,9a‐dimethyl‐1,3a,4,7,7a,7b,8,9,9a,10,11,12,12a,12b‐tetradecahydro‐3H‐benzo[c]indeno[5,4‐e]oxepin‐3‐one)) on hormone‐dependent breast cancer cells and normal epithelial cells and its impact on the estrogen receptor signaling were evaluated. Cytotoxicity was assessed by MTT‐test; expression of estrogen receptor α and survivin was measured by immunoblotting. Transactivation analysis of luciferase reporter gene was performed for ERα and AP‐1 factors after the brassinosteroid treatment. Dock6 and Autodock Vina were used for molecular docking. BS4 revealed a significant antiproliferative effect towards the hormone‐dependent breast cancer cells and was not active against normal epithelial cells. BS4 action on MCF‐7 breast cancer cells was found to be complex: a decrease in ERα expression as well as in its transcription activity was accompanied by inhibition of ERα‐related signaling pathways (AP‐1 complex and survivin). BS4 binding mode to ERα ligand‐binding domain was analyzed by molecular docking. The obtained results show that antiproliferative and antiestrogenic properties of the brassinosteroid BS4, as well as its ability to inhibit the anti‐apoptotic protein survivin may be of interest for further development of anticancer agents.

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Section: Introductionmentioning

confidence: 91%

Biological Evaluation of a New Brassinosteroid: Antiproliferative Effects and Targeting Estrogen Receptor α Pathways

Scherbakov

Жабинский

Хрипач

et al. 2019

Chemistry & Biodiversity

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“…The fungal kingdom is a unique biological association of living organisms that produces a wide variety of metabolites, many of which exhibit diverse biological activities that are beneficial to human health [ 131 , 132 , 133 , 134 ]. Fungi are known to produce steroids and isoprenoid lipids, which can possess both toxic and valuable biological activities [ 134 , 135 , 136 , 137 ]. It is worth noting that fungal endophytes, which widely inhabit plants [ 138 , 139 , 140 ], are likely responsible for the synthesis of these steroids and isoprenoid lipids.…”

Section: Miscellaneous Steroids With αβ-Epoxy Group Derived From Diff...mentioning

confidence: 99%

Bioactive Steroids Bearing Oxirane Ring

Dembitsky

2023

Biomedicines

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This review explores the biological activity and structural diversity of steroids and related isoprenoid lipids, with a particular focus on compounds containing an oxirane ring. These natural compounds are derived from fungi, fungal endophytes, as well as extracts of plants, algae, and marine invertebrates. To evaluate their biological activity, an extensive examination of refereed literature sources was conducted, including in vivo and in vitro studies and the utilization of the QSAR method. Notable properties observed among these compounds include strong anti-inflammatory, antineoplastic, antiproliferative, anti-hypercholesterolemic, antiparkinsonian, diuretic, anti-eczematic, anti-psoriatic, and various other activities. Throughout this review, 3D graphs illustrating the activity of individual steroids are presented, accompanied by images of selected terrestrial or marine organisms. Furthermore, this review provides explanations for specific types of biological activity associated with these compounds. The data presented in this review are of scientific interest to the academic community and carry practical implications in the fields of pharmacology and medicine. By analyzing the biological activity and structural diversity of steroids and related isoprenoid lipids, this review offers valuable insights that contribute to both theoretical understanding and applied research. This review draws upon data from various authors to compile information on the biological activity of natural steroids containing an oxirane ring.

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“…The physiological phenomenon of development of novel blood vessels from previously formed micro vessels is termed as angiogenesis [132]. These are required to meet the demand of oxygen [133] and nutrients supply in animals for their organ growth as well as solid tumors, wound healing, in fetal and embryonal development, placenta formation, and for metastasis [134]. Angiogenesis is a highly regulated process in which endothelial cells are a major component of its tissues [135], which are targeted for antiangiogenic therapy.…”

Section: Antiangiogenic Activities and Antigenotoxicmentioning

confidence: 99%

Therapeutic Potential of Brassinosteroids in Biomedical and Clinical Research

Kohli

Bhardwaj

et al. 2020

Biomolecules

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Steroids are a pivotal class of hormones with a key role in growth modulation and signal transduction in multicellular organisms. Synthetic steroids are widely used to cure large array of viral, fungal, bacterial, and cancerous infections. Brassinosteroids (BRs) are a natural collection of phytosterols, which have structural similarity with animal steroids. BRs are dispersed universally throughout the plant kingdom. These plant steroids are well known to modulate a plethora of physiological responses in plants leading to improvement in quality as well as yield of food crops. Moreover, they have been found to play imperative role in stress-fortification against various stresses in plants. Over a decade, BRs have conquered worldwide interest due to their diverse biological activities in animal systems. Recent studies have indicated anticancerous, antiangiogenic, antiviral, antigenotoxic, antifungal, and antibacterial bioactivities of BRs in the animal test systems. BRs inhibit replication of viruses and induce cytotoxic effects on cancerous cell lines. Keeping in view the biological activities of BRs, this review is an attempt to update the information about prospects of BRs in biomedical and clinical application.

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Anticancer Potential of Brassinosteroids

Cited by 6 publications

References 59 publications

Biological Evaluation of a New Brassinosteroid: Antiproliferative Effects and Targeting Estrogen Receptor α Pathways

Biological Evaluation of a New Brassinosteroid: Antiproliferative Effects and Targeting Estrogen Receptor α Pathways

Bioactive Steroids Bearing Oxirane Ring

Therapeutic Potential of Brassinosteroids in Biomedical and Clinical Research

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