Anticancer potential of dihydrocaffeic acid: a chlorogenic acid metabolite

Santana-Gálvez, Jesús; Villela-Castrejón, Javier; Serna‐Saldívar, Sergio O.; Jacobo‐Velázquez, Daniel A.

doi:10.1080/19476337.2020.1743762

Cited by 36 publications

(25 citation statements)

References 20 publications

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“…In another study, the anticancer potential of dihydrocaffeic acid as a metabolite of chlorogenic acid using several cancer cell lines, including MCF7, HepG2, PC3, and HCT116, was explored. The authors found dihydrocaffeic acid to be significantly more cytotoxic to all cancer cell lines except Hep-G2, with a cytotoxic dose ranging between 162 and 390 M in PC3 [ 68 ]. In a study on the effectiveness of chlorogenic acid as a chemosensitizer in inhibiting tumor growth via metabolic pathways, this agent had the ability to stimulate and suppress many vital signaling pathways in cancer metabolism [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Efficacy of Olive Leaf (Olea europaea L.) Extracts in the Treatment of Colorectal Cancer and Prostate Cancer Using In Vitro Cell Models

Albogami

Hassan

2021

Molecules

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Cancer is one of the most serious public health issues worldwide, ranking second only to cardiovascular diseases as a cause of death. Numerous plant extracts have extraordinary health benefits and have been used for centuries to treat a variety of ailments with few side effects. Olive leaves have a long history of medicinal and therapeutic use. In this study, the anti-cancer properties of an olive leaf extract were investigated in vitro using colorectal and prostate cancer cell lines (HT29 and PC3, respectively). A high-performance liquid chromatography analysis showed that the olive leaf extract contained a high chlorogenic acid content. Accordingly, chlorogenic acid may be related to the observed effects of the aqueous extract on cancer cells, including increased inhibition of cancer cell growth, migration, DNA fragmentation, cell cycle arrest at the S phase, reactive oxygen species (ROS) production, and altered gene expression. The effects of the extracts were greater in HT29 than in PC3 cells. These results suggest that chlorogenic acid, the main constituent in the olive extract, is a promising new anti-cancer agent. Further analyses should focus on its in vivo effects on colorectal tumor models, both alone and in combination with established agents.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Efficacy of Olive Leaf (Olea europaea L.) Extracts in the Treatment of Colorectal Cancer and Prostate Cancer Using In Vitro Cell Models

Albogami

Hassan

2021

Molecules

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“…For example, chlorogenic acid is recognized both for its nutritional and health benefits. Its activity against human breast, lung, colon, bone, and kidney cancers was demonstrated in vitro [ 28 ], while an in vivo study found antitumoral activity against colon cancer in rats [ 29 ]. Vanillic acid inhibited cell proliferation through a G1 phase arrest and an angiogenesis suppression, the antitumor activity was confirmed in a murine xenograft model with no apparent toxicity to the animals [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds

et al. 2021

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Leukemia is a group of hematological neoplastic disorders linked to high mortality rates worldwide, but increasing resistance has led to the therapeutic failure of conventional chemotherapy. This study aimed to evaluate in vitro the antileukemic activity and potential mechanism of action of a polyphenolic extract obtained from the seeds of Coriandrum sativum L. (CSP). A methylthiazoletetrazolium assay was performed to assess the CSP cytotoxicity on chronic (K562) and acute (HL60) myeloid leukemia cell lines and on normal Vero cell line. CSP toxicity was also evaluated in vivo using the OECD 423 acute toxicity model on Swiss albino mice. The results demonstrated a remarkable antitumoral activity against K562 and HL60 cell lines (IC50 = 16.86 µM and 11.75 µM, respectively) although no cytotoxicity was observed for the Vero cells or mice. A silico study was performed on the following receptors that are highly implicated in the development of leukemia: ABL kinase, ABL1, BCL2, and FLT3. The molecular docking demonstrated a high affinity interaction between the principal CSP components and the receptors. Our findings demonstrated that CSP extract has remarkable antileukemic activity, which is mainly mediated by the flavonoids, catechins, and rutin, all of which showed the highest binding affinity for the targeted receptors. This study revealed a promising active compound alternative research-oriented biopharmacists to explore.

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“…In cancer biology, reactive oxygen species (ROS) are known as a double-edged sword, because the imbalance or accumulation of ROS lead to both the survival and death of cancer cells, respectively [ 44 , 45 ]. Particularly, it has been shown that ROS enhances the activation of the Raf/MEK/ERK signaling pathways to promote cancer cell survival, cell proliferation, cell migration, and differentiation [ 46 ], whereas ROS accumulation via pro-oxidants under severe oxidative stress conditions leads to apoptosis and cell death [ 47 ]. BF-treated SK-MEL-2 cells exhibited similar levels of ROS as compared with mock control ( Figure 3 ), suggesting that inactivation of MEK by BF-treatment ( Figure 2 A) was not mediated by ROS levels.…”

Section: Resultsmentioning

confidence: 99%

Anti-Melanoma Activities and Phytochemical Compositions of Sorbus commixta Fruit Extracts

Jin

Kim

et al. 2020

Plants

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Sorbus commixta Hedl. (Rosaceae family) has a long history as a medicinal plant in East Asian countries. In this study, we evaluated the effect of S. commixta fruit extracts prepared with different ethanol concentrations on anti-melanoma activity, and the extraction yield of phenolic compounds and flavonoids. Using the partitioned fractions from the EtOH extract, we found that the butanol fraction (BF) possessed strong cytotoxic activity against SK-MEL-2 cells (human melanoma cells) but not against HDFa cells (human dermal fibroblast adult cells). Additionally, BF-induced cell death was mediated by the inhibition of the mitogen-activated protein kinase/extracellular regulated kinase (MEK/ERK) signaling pathway, coupled with the upregulation of caspase-3 activity in SK-MEL-2 cells. Furthermore, HPLC analysis of polyphenolic compounds suggested that S. commixta fruits contained several active compounds including chlorogenic acid, rutin, protocatechuic acid, and hydroxybenzoic acid, all of which are known to possess anti-cancer activities. Although this study has been carried out by cell-based approach, these results suggest that S. commixta fruits contain promising anti-melanoma compounds.

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Anticancer potential of dihydrocaffeic acid: a chlorogenic acid metabolite

Cited by 36 publications

References 20 publications

Assessment of the Efficacy of Olive Leaf (Olea europaea L.) Extracts in the Treatment of Colorectal Cancer and Prostate Cancer Using In Vitro Cell Models

Assessment of the Efficacy of Olive Leaf (Olea europaea L.) Extracts in the Treatment of Colorectal Cancer and Prostate Cancer Using In Vitro Cell Models

Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds

Anti-Melanoma Activities and Phytochemical Compositions of Sorbus commixta Fruit Extracts

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