Anticancer potential of oroxylin A: from mechanistic insight to synergistic perspectives

Tuli, Hardeep Singh; Garg, Vivek Kumar; Kumar, Ajay; Aggarwal, Diwakar; Anand, Uttpal; Parashar, Nidarshana Chaturvedi; Saini, Adesh K.; Mohapatra, Ranjan K.; Dhama, Kuldeep; Kumar, Manoj; Singh, Tejveer; Kaur, Jagjit; Sak, Katrin

doi:10.1007/s00210-022-02298-0

Cited by 3 publications

(2 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, the surface of the material can be modified to improve its biological targeting properties by adding chemicals that interact with tumour cells. Finally, the biodegradability of nanomaterials used in biomimetic fabrication and modification of nanomaterials for controlled cancer detection and therapy can be improved by using biomolecules such as proteins, DNA and peptides [204][205][206]. In recent years, there has been a lot of buzz about a new type of cancer treatment called gas therapy (GT).…”

mentioning

confidence: 99%

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Soni

Bhandari

Tripathi

et al. 2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach to improve the drug delivery system for tumour and cancer diseases. In this article, we review current strategies to improve tumour and cancer drug delivery, which mainly focuses on sustaining biocompatibility, biodistribution, and active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, and paclitaxel has its own challenges especially not being able to discriminate between tumour versus normal cells which eventually led to toxicity and side effects in the patients. In contrast to the conventional approach, nanoparticle-based drug delivery provides target-specific delivery and controlled release of the drug, which provides a better therapeutic window for treatment options by focusing on the eradication of diseased cells via active targeting and sparing normal cells via passive targeting. Additionally, treatment of tumours associated with the brain is hampered by the impermeability of the blood-brain barriers to the drugs, which eventually led to poor survival in the patients. Nanoparticle-based therapy offers superior delivery of drugs to the target by breaching the blood-brain barriers. Herein, we provide an overview of the properties of nanoparticles that are crucial for nanotechnology applications. We address the potential future applications

show abstract

mentioning

confidence: 99%

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Soni

Bhandari

Tripathi

et al. 2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…They have been shown to improve cancer prognosis through a variety of biological processes that increase apoptosis and prevent cancer growth [12]. Furthermore, phytochemicals have been shown to have strong anticancer effects, triggering apoptosis and autophagy, and decreasing tumor cell resistance to chemotherapeutic drugs in gastric cancer [15][16][17][18][19][20][21]. Some phytochemicals have been examined for their potential impact on GI cancer, including quercetin, ellagic acid, allicin, curcumins, and others [12,15,[22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The Role of Phytonutrient Kaempferol in the Prevention of Gastrointestinal Cancers: Recent Trends and Future Perspectives

Singh,

Sharma,

Sharma

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

In recent years, kaempferol, a natural flavonoid present in various fruits and vegetables, has received significant attention in gastrointestinal cancer research due to its varied therapeutic effects. Kaempferol has been proven to alter several molecular mechanisms and pathways, such as the PI3/Akt, mTOR, and Erk/MAPK pathway involved in cancer progression, showing its inhibitory effects on cell proliferation, survival, angiogenesis, metastasis, and migration. Kaempferol is processed in the liver and small intestine, but limited bioavailability has been a major concern in the clinical implications of kaempferol. Nano formulations have been proven to enhance kaempferol’s efficacy in cancer prevention. The synergy of nanotechnology and kaempferol has shown promising results in in vitro studies, highlighting the importance for more in vivo research and clinical trials to determine safety and efficacy. This review aims to focus on the role of kaempferol in various types of gastrointestinal cancer and how the combination of kaempferol with nanotechnology helps in improving therapeutic efficacy in cancer treatment.

show abstract