Anticancer Potential of Thymoquinone: A Novel Bioactive Natural Compound from
<i>Nigella sativa</i> L.

Mir, Prince Ahad; Mohi-ud-din, Roohi; Banday, Nazia; Maqbool, Mudasir; Raza, Syed Naeim; Farooq, Saeema; Afzal, Suhaib; Mir, Reyaz Hassan

doi:10.2174/1871520622666220511233314

Cited by 13 publications

(2 citation statements)

References 174 publications

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“…Moreover, CD treatment inhibited the translation and promoted the degradation of TMPRSS2. CD, TQ, and TQFL12 have anti-cancer suppressive roles both in vitro and in vivo [ 38 , 39 , 40 , 41 ]. Natural product CD is a derivative (analog) from AD, while TQFL12 is a novel synthetic derivative from TQ [ 38 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2

Tan

Liu

et al. 2022

Molecules

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As a cellular protease, transmembrane serine protease 2 (TMPRSS2) plays roles in various physiological and pathological processes, including cancer and viral entry, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we conducted expression, mutation, and prognostic analyses for the TMPRSS2 gene in pan-cancers as well as in COVID-19-infected lung tissues. The results indicate that TMPRSS2 expression was highest in prostate cancer. A high expression of TMPRSS2 was significantly associated with a short overall survival in breast invasive carcinoma (BRCA), sarcoma (SARC), and uveal melanoma (UVM), while a low expression of TMPRSS2 was significantly associated with a short overall survival in lung adenocarcinoma (LUAD), demonstrating TMPRSS2 roles in cancer patient susceptibility and severity. Additionally, TMPRSS2 expression in COVID-19-infected lung tissues was significantly reduced compared to healthy lung tissues, indicating that a low TMPRSS2 expression may result in COVID-19 severity and death. Importantly, TMPRSS2 mutation frequency was significantly higher in prostate adenocarcinoma (PRAD), and the mutant TMPRSS2 pan-cancer group was significantly associated with long overall, progression-free, disease-specific, and disease-free survival rates compared to the wild-type (WT) TMPRSS2 pan-cancer group, demonstrating loss of functional roles due to mutation. Cancer cell lines were treated with small molecules, including cordycepin (CD), adenosine (AD), thymoquinone (TQ), and TQFL12, to mediate TMPRSS2 expression. Notably, CD, AD, TQ, and TQFL12 inhibited TMPRSS2 expression in cancer cell lines, including the PC3 prostate cancer cell line, implying a therapeutic role for preventing COVID-19 in cancer patients. Together, these findings are the first to demonstrate that small molecules, such as CD, AD, TQ, and TQFL12, inhibit TMPRSS2 expression, providing novel therapeutic strategies for preventing COVID-19 and cancers.

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Section: Discussionmentioning

confidence: 99%

Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2

Tan

Liu

et al. 2022

Molecules

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“…A phytochemical found in black seed (Nigella sativa), thymoquinone is widely utilized in traditional medicine in the Middle East, the Mediterranean, South Asia, and Africa. Recent research has discovered that TQ has an adverse effect against many cancer subtypes and suppressed cellular growth in several cancer cell lines, including breast, colon, larynx, lung, myeloblastic leukemia, osteosarcoma, ovary, and pancreatic [126][127][128]. According to a study by Zhu et al, TQ inhibited the expression of multiple STAT3-regulated genes in gastric cancer HGC27 cells, including proliferative (cyclin D1), anti-apoptotic (Bcl-2, survivin), and angiogenic (VEGF) gene products [61].…”

Section: Monoterpenementioning

confidence: 99%

Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies

Khan,

Pandey,

Verma

et al. 2024

Biomolecules

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Cancer has become one of the most multifaceted and widespread illnesses affecting human health, causing substantial mortality at an alarming rate. After cardiovascular problems, the condition has a high occurrence rate and ranks second in terms of mortality. The development of new drugs has been facilitated by increased research and a deeper understanding of the mechanisms behind the emergence and advancement of the disease. Numerous preclinical and clinical studies have repeatedly demonstrated the protective effects of natural terpenoids against a range of malignancies. Numerous potential bioactive terpenoids have been investigated in natural sources for their chemopreventive and chemoprotective properties. In practically all body cells, the signaling molecule referred to as signal transducer and activator of transcription 3 (STAT3) is widely expressed. Numerous studies have demonstrated that STAT3 regulates its downstream target genes, including Bcl-2, Bcl-xL, cyclin D1, c-Myc, and survivin, to promote the growth of cells, differentiation, cell cycle progression, angiogenesis, and immune suppression in addition to chemotherapy resistance. Researchers viewed STAT3 as a primary target for cancer therapy because of its crucial involvement in cancer formation. This therapy primarily focuses on directly and indirectly preventing the expression of STAT3 in tumor cells. By explicitly targeting STAT3 in both in vitro and in vivo settings, it has been possible to explain the protective effect of terpenoids against malignant cells. In this study, we provide a complete overview of STAT3 signal transduction processes, the involvement of STAT3 in carcinogenesis, and mechanisms related to STAT3 persistent activation. The article also thoroughly summarizes the inhibition of STAT3 signaling by certain terpenoid phytochemicals, which have demonstrated strong efficacy in several preclinical cancer models.

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Therapeutic potential of plant-derived flavonoids against inflammation

Mir

Mohi-ud-din

Mir

et al. 2023

Recent Developments in Anti-Inflammatory Therapy

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Anticancer Potential of Thymoquinone: A Novel Bioactive Natural Compound from Nigella sativa L.

Cited by 13 publications

References 174 publications

Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2

Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2

Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies

Therapeutic potential of plant-derived flavonoids against inflammation

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