Anticancer Properties of Curcumin Against Colorectal Cancer: A Review

Ojo, Oluwafemi Adeleke; Adeyemo, Temiloluwa Rhoda; Rotimi, Damilare; Batiha, Gaber El‐Saber; Mostafa‐Hedeab, Gomaa; Iyobhebhe, Matthew; Elebiyo, Tobiloba Christiana; Atunwa, Bukola; Ojo, Adebola Busola; Lima, Clara Mariana Gonçalves; Conté-Júnior, Carlos Adam

doi:10.3389/fonc.2022.881641

Cited by 58 publications

(51 citation statements)

References 68 publications

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“…Similarly, Cur exerts several antitumor properties against CRC acting through a variety of cellular signaling pathways [17]. First, Cur could interrupt the cell cycle and accelerate cell death, and this effect can assist in inhibition of the metastatic ability of CRC cells [11]. Second, the anticancer potential of Cur on CRC can be mediated by activating the cell death pathway [11].…”

Section: Discussionmentioning

confidence: 99%

“…Third, Cur can reduce chemoresistant cancer cells by acting on the population of CRC stem cells [11]. Finally, Cur can regulate gut ora, thus in uencing CRC progression [11]. A randomized controlled trial reported that supplementation with 500 mg curcuminoids/day for 8 weeks can improve the functional scales and global quality of life compared to placebo in patients with stage 3 CRC [30].…”

Section: Discussionmentioning

confidence: 99%

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Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Qin

et al. 2022

Preprint

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Background: Curcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer (CRC) is one of the leading causes of cancer mortality worldwide. Intestinal cholesterol homeostasis is associated with CRC. A variety of side effects have been observed in patients with CRC because of treatment with chemotherapeutic drugs. Therefore, natural products can be an important strategy for potentially developing a com-plementary option for the primary prevention of CRC. Methods: The present study used Cur as a therapeutic approach against CRC using the Caco-2 cell line. Based on the relative cell viability assessment up to a 100 μM concentration of Cur, a low-toxic concentration of 10 μM was adopted for further investigation. Results: Cur inhibited cell proliferation in Caco-2 cells in a dose-dependent manner by activating the TRPA1 channel. Furthermore, the Cur-activated TRPA1 channel led to increased intracellular calcium, PPARγ upregulation, and the subsequent downregulation of the SP-1/SREBP-2/NPC1L1 signaling pathway-related proteins, and finally reduce cholesterol absorp-tion in Caco-2 cells. Conclusions: Cur inhibits cell proliferation and reduces cholesterol absorption in Caco-2 cells through the Ca2+/PPARγ/SP-1/SREBP-2/NPC1L1 signaling by activating the TRPA1 channel, suggesting that Cur can be used as a dietary supplement for the primary prevention of CRC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Qin

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Curcumin (CUR)-an active polyphenol extracted from the dried rhizomes of Curcuma longa-has been traditionally used for dietary and medical purposes worldwide (Li KX. et al, 2022;Jin et al, 2022;Ojo et al, 2022). CUR shows a wide range of pharmacological activities, including anti-inflammatory and antioxidant activities, in various disease models (Yang et al, 2020;Uddin et al, 2021;Fan and Lei, 2022).…”

Section: Curcuminmentioning

confidence: 99%

Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals

et al. 2022

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Low back pain is a major cause of disability worldwide that declines the quality of life; it poses a substantial economic burden for the patient and society. Intervertebral disc (IVD) degeneration (IDD) is the main cause of low back pain, and it is also the pathological basis of several spinal degenerative diseases, such as intervertebral disc herniation and spinal stenosis. The current clinical drug treatment of IDD focuses on the symptoms and not their pathogenesis, which results in frequent recurrence and gradual aggravation. Moreover, the side effects associated with the long-term use of these drugs further limit their use. The pathological mechanism of IDD is complex, and oxidative stress and inflammation play an important role in promoting IDD. They induce the destruction of the extracellular matrix in IVD and reduce the number of living cells and functional cells, thereby destroying the function of IVD and promoting the occurrence and development of IDD. Phytochemicals from fruits, vegetables, grains, and other herbs play a protective role in the treatment of IDD as they have anti-inflammatory and antioxidant properties. This article reviews the protective effects of phytochemicals on IDD and their regulatory effects on different molecular pathways related to the pathogenesis of IDD. Moreover, the therapeutic limitations and future prospects of IDD treatment have also been reviewed. Phytochemicals are promising candidates for further development and research on IDD treatment.

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“…Curcumin (CUR) is known for its therapeutic properties; among these, antioxidant, anti-inflammatory and anti-cancer ones stand out [ 1 , 2 ]. Unfortunately, curcumin is poorly water-soluble and bioavailable [ 3 ]; these are the drawbacks that hamper its great therapeutic properties and hold back its use in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs

et al. 2022

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Curcumin is known for its therapeutic properties; among these, antioxidant, anti-inflammatory and anti-cancer ones stand out. Besides, curcumin metal complexes have shown widespread application in medicine and can be exploited as lead structures for developing metal-based drugs. Unfortunately, curcumin is poorly bioavailable, mainly due to its instability in physiological conditions; this weakness is tightly connected to the presence of the β-diketo moiety undergoing tautomeric equilibrium. Stability and metal-chelating ability can be tuned by modulating the electronic effects and steric hindrance close to the β-diketo moiety; in addition, formation of a metal complex shifts the tautomeric equilibrium towards the β-keto–enol form and increases stability in biological media. Among the metals used in clinical therapy, gallium nitrate has shown to have significant antitumor activity against non-Hodgkin lymphoma and bladder cancer, thus indicating that gallium-based drugs have potential for further development as antineoplastic agents with improved therapeutic activity. Curcuminoids have demonstrated high affinity for gallium(III), allowing the formation of stable positively charged M:L 1:2 β-diketonate complexes that benefit from the therapeutic activity of both the metal and the ligand. Seven new curcumin derivatives were synthesized and completely characterized. The new derivatives retain the solvent-dependent keto–enol tautomerism, with the prevalence of the diketo form in aqueous solution. Enhanced stability in simulated physiological conditions was observed in comparison to the lead compound curcumin. The presence of Ga3+ anticipates the dissociation of the enolic proton, allowing chelate complex formation, and simultaneously it shifts the tautomeric equilibrium towards the keto–enol form. A complete 1H/13C NMR and UV–Vis study was performed to define the metal-to-ligand stoichiometry ratio and the overall stability constants. In addition, we demonstrated that some of the derivatives have increased antiproliferative activity on colon cancer cells compared to curcumin and antioxidant properties. On the whole, the synthesized curcumin-based molecules may act as new gallium(III) chelators with improved stability with respect to curcumin and could open interesting perspectives for the development of novel therapeutic agents for cancer.

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Anticancer Properties of Curcumin Against Colorectal Cancer: A Review

Cited by 58 publications

References 68 publications

Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals

Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs

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