Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies

A comparative study on 2-(2-benzylidenehydrazinyl)-4-(3-methyl-3-phenylcyclobutyl) thiazole : X-ray, HF and DFT studies

“…The chemistry of aminothiazoles and their derivatives has attracted the attention of chemists, because they exhibit important biological activity in medicinal chemistry [5]. Thiazole derivatives exhibit different pharmaceutical properties such as anticancer [6,7], anticonvulsant [8], antipsychoticlike [9], antibacterial, antifungal [10,11], antitubercular [12], antimicrobial [13], analgesic and antiinflammatory [14] activities.…”

Synthesis of new oxindole derivatives containing benzothiazole and thiazolidinone moieties using nano silica-bonded 5-n-propyl-octahydro-pyrimido[1,2-a]azepinium chloride (NSB-DBU) as catalyst

“…1,2 They are reported to have antitumor, 3,4 anticonvulsant, 5 antibacterial, 6 antiviral, 7 cardiotonic, 8,9 and antidiabetic 10,11 properties. In particular, thiazolidinone-linked benzothiazole analogs have recently proven to be attractive compounds considering that benzothiazole derivatives have a wide spectrum of pharmacological activities.…”

New thiopyrano[2,3-d][1,3]thiazole derivatives as potential antiviral agents

“…A series of novel thiopyrano [2,3-d] [1,3] [2,3-d] [1,3] [4',3':4,5]thiopyrano [2,3- [2,3-d] [1,3]thiazoles, screening, antiviral activity. V iruses are known as common pathogens that cause a variety of diseases.…”

“…To overcome the drawbacks of the current antiviral drugs and to obtain more efficacious drugs, new antiviral drugs with a novel mode of action should be developed. Thiopyrano [2,3-d] [1,3]thiazoles have become a promising area of research because of their diverse biological activities, such as anticancer, antitrypanosomal, antimycobacterial, anti-inflammatory and antioxidant 1-7 ( Fig. 1).…”

“…In the last two decades, there has been an increase in the number of studies on 4-thiazolidinone derivatives as potential antiviral agents 8-13 . Thiopyrano [2,3-d] [1,3]thiazoles could be of special interest as cyclic mimetics of biologically active (including antiviral) 4-thiazolidinones. The aim of present study was to estimate the antiviral activity of new thiopyrano [2,3-d] [1,3]thiazole derivatives.…”