Anticarcinogenic Effects of Indigofera Aspalathoides on 20-Methylcholanthrene Induced Fibrosarcoma in Rats

Kumar, Surendra; Rao, Mudiganti Ram Krishna; Balasubram, M.P.

doi:10.3923/rjmp.2011.747.755

Cited by 16 publications

(8 citation statements)

References 7 publications

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“…The present study was aimed at finding out the curative role of the aqueous extract of Indigofera aspalathoides on 20-MCA-induced fibrosarcoma in rats. Some reports of its anticancer and antioxidant properties are already been studied by us [ 13 – 16 ]. The present study is to further know this plant's chemopreventive role on some more parameters like total DNA and RNA content and on parameters like hexose, hexosamine, and sialic acid.…”

Section: Introductionmentioning

confidence: 99%

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

2012

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The present study was undertaken to test the chemopreventive effects of one herbal medicinal plant, Indigofera aspalathoides, on chemically induced carcinogenesis in rats. A well-known polyaromatic hydrocarbon, namely, 20-methylcholanthrene, which is a known carcinogenic substance, was used to induce fibrosarcoma in Wistar strain of male albino rats. Fibrosarcoma rats were treated with aqueous extracts of Indigofera aspalathoides. The rats were divided into four groups, each consisting of six animals. Group I served as normal control, Group II served as fibrosarcoma-induced animals, Group III were fibrosarcoma-bearing animals treated with aqueous extracts of Indigofera aspalathoides, and Group IV animals, which were normal healthy animals treated with Indigofera aspalathoides aqueous extract, served as drug control set. Group III and Group IV animals were treated with aqueous extract of Indigofera aspalathoides intraperitoneally at a dose of 250 mg/kg. b.w. for 30 days. The fibrosarcoma was proved by pathological examinations. The activity levels of nucleic acids such as total DNA and RNA and hexose, hexosamine, and sialic acid in liver and kidney of treated rats were used to monitor the chemopreventive role of the plant extract. The observed increase in the levels of DNA, RNA, hexose, hexosamine, and sialic acid in liver and kidney tissues of fibrosarcoma-bearing animals reached near normal state after the treatment with aqueous extracts of Indigofera aspalathoides, suggesting that Indigofera aspalathoides does have a chemotherapeutic role.

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Section: Introductionmentioning

confidence: 99%

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

2012

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“…The activity levels of nucleic acids such as total DNA and RNA and hexose, hexosamine, and sialic acid in liver and kidney of treated rats were used to monitor the chemopreventive role of the plant extract. The observed increase in the levels of DNA, RNA, hexose, hexosamine, and sialic acid in liver and kidney tissues of fibrosarcoma-bearing animals reached near normal state after the treatment with aqueous extracts of Indigofera aspalathoides 15,16 .…”

Section: Anti-cancer Activitymentioning

confidence: 99%

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2013

IJPSR

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ABSTRACT:Since ancient times, herbal drugs are used in traditional system of medicine such as Siddha, Ayurveda and Unani. The allopathic system of medicine adopted many medicinal plants to derive newer molecules for challenging diseases. The plant Indigofera aspalathoides which is well known as 'Sivanar vembu' is widely used for skin diseases. Phytochemical and Pharmacological researchers have screened it for its anti-cancerous and antioxidant property. This review focuses all updated information about its authentication, phytochemistry and pharmacology. The phytochemical evaluation of the plant showed phenolic compounds, tannin, alkaloides, triterpenes, flavones, saponin and steroids. This drug is widely screened for its anti-cancerous and anti-oxidant activity. Anti-microbial, hypoglycemic, hepatoprotective, anti-inflammatory and antiviral activity were also reported. A thailam (oil prepared by traditional extraction procedure) prepared from this plant is widely used by the Siddha practioners for various ailments. This review focuses the lot of medicinal properties of the plant through the scientific validation and strongly supports the traditional claim.

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“…In another research, the flavonoid fraction of methanolic extract of I.tinctoria has been reported to have chemo protective effect against lung cancer [29]. So based on supported links regarding targeted anti-viral activity the current study is carried out to explore another specie Indigoferra gerardiana (IG) for possible antiviral activity [30], [31], [32], [33], [34], [35].…”

Section: Introductionmentioning

confidence: 99%

Anti-viral effect of Indigoferra gerardiana on core protein of HCV and clinical significance of serum markers in chronic HCV genotype 3a patients in district Peshawar

Mumtaz¹,

Ahmed²,

Tariq³

et al. 2020

Preprint

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Background/aim: Hepatitis C virus (HCV) disease is a health challenge due resistance cases globally. Many plant-derived natural compounds have demonstrated antiviral effects. These plants can provide an alternative way to new antiviral. Core protein of HCV has ability to interact with a wide range of viral and cellular proteins, including proto-oncogenes. Materials and Methods: In this cross-sectional study, total of 421 Hepatitis C Virus (HCV) positive patients were subjected by Polymerase Chain Reaction (PCR). The correlation of genotype with continuous and categorical variables was analyzed. Furthermore, antiviral activity of indigoferra gerardiana (IG) was tested against core protein of HCV. The amplified complete core protein of HCV genotype 3a was sequenced and cloned. IG was extracted and screened against core protein of HCV 3a genotype in cell line. Results: Genotype 3a was the common genotype type of HCV (n=363, 86%). Significant differences were observed in viral load among 3a genotype of HCV (< P 0.05). Frequently detected age group was 21-40 (59.4%) Sex and age were statistically associated with HCV infection (49% males and 37% in females). The results of RT-PCR demonstrated that methanolic extract of IG showed 57% reduction of infecting cells. Conclusions: Methanolic extract of IG showed good antiviral activity i.e. 57% reduction of infecting cells.

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Anticarcinogenic Effects of Indigofera Aspalathoides on 20-Methylcholanthrene Induced Fibrosarcoma in Rats

Cited by 16 publications

References 7 publications

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

Chemotherapeutic Efficacy ofIndigofera aspalathoideson 20-Methylcholanthrene-Induced Fibrosarcoma in Rats

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Anti-viral effect of Indigoferra gerardiana on core protein of HCV and clinical significance of serum markers in chronic HCV genotype 3a patients in district Peshawar

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