Anticarcinogenic potentials of tea catechins

Li, Xiaoxiang; Liu, Chang; Dong, Shuling; Ou, Can-Song; Lu, Jian-Liang; Ye, Jian-Hui; Liang, Yue-Rong; Zheng, Xin-Qiang

doi:10.3389/fnut.2022.1060783

Cited by 30 publications

(11 citation statements)

References 222 publications

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“…Catechins, in turn, have been shown to inhibit tumorigenesis, tumor growth, cancer cell invasion and tumor angiogenesis by inhibiting the induction of proangiogenic factors [54]. Several in vitro cell experiments and in vivo animal experiments have shown that catechins have a strong anticarcinogenic effect and effectively suppress the metastasis and invasion of various cancer cells [55]. It should be noted that the flower extracts of wild plants also show good cytotoxic activity against cancer cells, with no significant damaging effects on control cells, especially at 24 h, but the best ratio (cancer cell cytotoxic activity/no harm to healthy cells) remains attributed to the cultivated flower extract at 48 h at a dosage of 500 µg/mL for the HT-29 and HeLa tumor cell lines.…”

Section: Discussionmentioning

confidence: 99%

Antitumor and Antioxidant Activities of In Vitro Cultivated and Wild-Growing Clinopodium vulgare L. Plants

Petrova

Dimitrova

et al. 2023

Plants

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Clinopodium vulgare L. is a valuable medicinal plant used for its anti-inflammatory, antibacterial and wound-healing properties. The present study describes an efficient protocol for the micropropagation of C. vulgare and compares, for the first time, the chemical content and composition and antitumor and antioxidant activities of extracts from in vitro cultivated and wild-growing plants. The best nutrient medium was found to be Murashige and Skoog (MS) supplemented with 1 mg/L BAP and 0.1 IBA mg/L, yielding on average 6.9 shoots per nodal segment. Flower aqueous extracts from in vitro plants had higher total polyphenol content (29,927.6 ± 592.1 mg/100 g vs. 27,292.8 ± 85.3 mg/100 g) and ORAC antioxidant activity (7281.3 ± 82.9 µmol TE/g vs. 7246.3 ± 62.4 µmol TE/g) compared to the flowers of wild plants. HPLC detected qualitative and quantitative differences in phenolic constituents between the in vitro cultivated and wild-growing plants’ extracts. Rosmarinic acid was the major phenolic constituent, being accumulated mainly in leaves, while neochlorogenic acid was a major compound in the flowers of cultivated plants. Catechin was found only in cultivated plants, but not in wild plants or cultivated plants’ stems. Aqueous extracts of both cultivated and wild plants showed significant in vitro antitumor activity against human HeLa (cervical adenocarcinoma), HT-29 (colorectal adenocarcinoma) and MCF-7 (breast cancer) cell lines. The best cytotoxic activity against most of the cancer cell lines, combined with the least detrimental effects on a non-tumor human keratinocyte cell line (HaCaT), was shown by the leaf (250 µg/mL) and flower (500 µg/mL) extracts of cultivated plants, making cultivated plants a valuable source of bioactive compounds and a suitable candidate for anticancer therapy.

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Section: Discussionmentioning

confidence: 99%

Antitumor and Antioxidant Activities of In Vitro Cultivated and Wild-Growing Clinopodium vulgare L. Plants

Petrova

Dimitrova

et al. 2023

Plants

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“…Flavanols are mostly found in variety of foods, including apples, pears, legumes, tea, cocoa, and wine. 95 NG from grapefruits and HP from oranges are the two most important flavanones. 96 Prenylated flavanones, furanoflavanones, pyranoflavanones, and benzylated flavanones, for example, have distinct substitution patterns, resulting in many substituted derivatives in this subgroup.…”

Section: Classification Of Various Polyphenols and Their Role In Canc...mentioning

confidence: 99%

“…Flavanols are composed of simple monomers (catechins), which consist of epicatechin, epigallocatechin (EGC), EGCG, and polymers and/or oligomers, the latter two of which are identified as pro-ACDs or condensed tannins. Flavanols are mostly found in variety of foods, including apples, pears, legumes, tea, cocoa, and wine . NG from grapefruits and HP from oranges are the two most important flavanones .…”

Section: Classification Of Various Polyphenols and Their Role In Canc...mentioning

confidence: 99%

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

Tomar,

Das,

Balaga

et al. 2024

ACS Appl. Bio Mater.

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Cancer is one of the major causes of death worldwide, even the second foremost cause related to non-communicable diseases. Cancer cells typically possess several cellular and biological processes including, persistence, propagation, differentiation, cellular death, and expression of cellular-type specific functions. The molecular picture of carcinogenesis and progression is unwinding, and it appears to be a tangled combination of processes occurring within and between cancer cells and their surrounding tissue matrix. Polyphenols are plant secondary metabolites abundant in fruits, vegetables, cereals, and other natural plant sources. Natural polyphenols have implicated potential anticancer activity by various mechanisms involved in their antitumor action, including modulation of signaling pathways majorly related to cellular proliferation, differentiation, relocation, angiogenesis, metastatic processes, and cell death. The applications of polyphenols have been limited due to the hydrophobic nature and lower oral bioavailability that could be possibly overcome through encapsulating them into nanocarrier-mediated delivery systems, leading to improved anticancer activity. Nanoemulsions (NEs) possess diverse feasible properties, including greater surface area, modifiable surficial charge, higher half-life, site-specific targeting, and formulation imaging capability necessary to create a practical therapeutic impact, and have drawn increased attention in cancer therapy research. This review has summarized and discussed the basic concepts, classification, delivery approaches, and anticancer mechanism of various polyphenols and polyphenols-encapsulated nanoemulsions with improved cancer therapy.

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“…However, many epidemiological studies have not yielded constant or conclusive results on the health benefits of tea consumption in humans. For example, EGCG has shown anticancer effects both on cultured cancer cells and in mouse tumor models with strong evidence (Li, Liu, et al., 2022), but there are no clear conclusions in humans. The anticancer effects of EGCG are still controversial in human studies at present.…”

Section: Challenges and Future Directions For Stpfcsmentioning

confidence: 99%

Special tea products featuring functional components: Health benefits and processing strategies

Yang

Meng

Shi

et al. 2023

Comp Rev Food Sci Food Safe

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The functional components in tea confer various potential health benefits to humans. To date, several special tea products featuring functional components (STPFCs) have been successfully developed, such as O‐methylated catechin‐rich tea, γ‐aminobutyric acid‐rich tea, low‐caffeine tea, and selenium‐rich tea products. STPFCs have some unique and enhanced health benefits when compared with conventional tea products, which can meet the specific needs and preferences of different groups and have huge market potential. The processing strategies to improve the health benefits of tea products by regulating the functional component content have been an active area of research in food science. The fresh leaves of some specific tea varieties rich in functional components are used as raw materials, and special processing technologies are employed to prepare STPFCs. Huge progress has been achieved in the research and development of these STPFCs. However, the current status of these STPFCs has not yet been systematically reviewed. Here, studies on STPFCs have been comprehensively reviewed with a focus on their potential health benefits and processing strategies. Additionally, other chemical components with the potential to be developed into special teas and the application of tea functional components in the food industry have been discussed. Finally, suggestions on the promises and challenges for the future study of these STPFCs have been provided. This paper might shed light on the current status of the research and development of these STPFCs. Future studies on STPFCs should focus on screening specific tea varieties, identifying new functional components, evaluating health‐promoting effects, improving flavor quality, and elucidating the interactions between functional components.

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Anticarcinogenic potentials of tea catechins

Cited by 30 publications

References 222 publications

Antitumor and Antioxidant Activities of In Vitro Cultivated and Wild-Growing Clinopodium vulgare L. Plants

Antitumor and Antioxidant Activities of In Vitro Cultivated and Wild-Growing Clinopodium vulgare L. Plants

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

Special tea products featuring functional components: Health benefits and processing strategies

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