Anticardiolipin antibodies and antiphospholipid syndrome in chronic discoid lupus erythematosus

Ruffatti, Amelia; Veller-Fornasa, C; Patrassi, G; Sartori, Elena; Tonello, Marta; Tonetto, S.; Peserico, Andrea; Todesco, S

doi:10.1007/bf02207672

Cited by 18 publications

(9 citation statements)

References 6 publications

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“…Patients with cutaneous forms of lupus are less likely to have positive serology, although antiRo/Sjögren's syndrome A (SS-A) antibodies are noted in up to 70% of cases of subacute cutaneous LE [18] and about 50% of cases of discoid LE have a positive ANA [19]. Anticardiolipin antibodies are also described in discoid lupus, with a frequency of 68% [20]. In our cohort the ANA was negative in most carriers (73%) and of low titre in the others.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology

Cale

Morton

Green

2007

Clinical and Experimental Immunology

137

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SummaryThe objective of this study was to determine the utility of anti-nuclear antibody (ANA) testing in the investigation of cutaneous and other lupus symptoms in female carriers of X-linked chronic granulomatous disease (CGD). We undertook a prospective study of 19 carrier mothers attending our institution, with direct questioning of carriers concerning symptoms and testing for anti-nuclear and anti-phospholipid antibodies. A total of 58% reported significant photosensitive skin rashes, 42% reported mouth ulcers and 37% complained of joint pains that could not be attributed to other known causes. Anti-nuclear antibody (ANA) testing was negative in 73% of all carriers. The five positive ANAs were of low titre (maximum 1 : 320 on Hep 2 cells in two women) and only one weak positive double-stranded DNA antibody and no extractable nuclear antibodies were found. Several of the mothers, despite negative serology, benefited from referral to a specialist, and in some cases to specific treatment. A history of skin rashes, joint pain, fatigue and mouth ulcers should be sought actively in the female relatives of X-CGD patients but negative lupus serology should not preclude referral to appropriate dermatology or rheumatology services. as symptoms may respond well to appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology

Cale

Morton

Green

2007

Clinical and Experimental Immunology

137

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“…Anticorpos ACL têm sido detectados em até 40% dos pacientes com LES (1) . Anticorpos ACL tipo IgG têm sido demonstrados com uma freqüência variável de 39,4% a 67,8% nos pacientes com LECD, e ACL tipo IgM com uma freqüência de 15,2% a 50% nos pacientes (24,25,26) . No entanto, pacientes com síndrome antifosfolípide raramente apresentam lúpus discóide sem evidência clínica ou sorológica de LES (10) .…”

Section: Discussionunclassified

Marcadores de envolvimento sistêmico no lúpus eritematoso crônico discóide

Marçon¹,

Moraes²,

Lanzelotti³

et al. 2004

Rev. Bras. Reumatol.

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“…7 Elevated titers of IgG or IgM aCL have been demonstrated in over 50% of patients with DLE, 8,9 and a single study found that 1 of 28 patients with DLE fulfilled the criteria for primary APS. 9 Longitudinal follow-up studies in DLE, however, are lacking. Progression from APS through to SLE is not common.…”

Section: The Casementioning

confidence: 98%

Conversion of discoid lupus to antiphospholipid syndrome and SLE

Fernando

Isenberg

2008

Nat Rev Rheumatol

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Pulsed intravenous methylprednisolone and a single infusion of intravenous cyclophosphamide, followed by oral prednisolone, were initially administered for presumed cerebral lupus. When renal biopsy revealed dual pathology, another dose of intravenous cyclophosphamide was administered with intravenous heparin therapy to treat systemic lupus erythematosus and APS, respectively. Intravenous immunoglobulin was used to treat thrombocytopenia, which was unresponsive to immunosuppression and anticoagulation. Gradual improvement occurred with maximal antihypertensive therapy and supportive treatment. The patient was discharged after 9 months of hospital treatment. His medication at this stage included warfarin, clopidogrel, prednisolone, carbamazepine, ramipril, atenolol, calcium and vitamin D supplements, and alendronate.

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Anticardiolipin antibodies and antiphospholipid syndrome in chronic discoid lupus erythematosus

Cited by 18 publications

References 6 publications

Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology

Cutaneous and other lupus-like symptoms in carriers of X-linked chronic granulomatous disease: incidence and autoimmune serology

Marcadores de envolvimento sistêmico no lúpus eritematoso crônico discóide

Conversion of discoid lupus to antiphospholipid syndrome and SLE

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