Anticardiolipin antibodies and ulcerations of the leg

Barbaud, A.; Gobert, B.; Reichert, Sophie; Schmutz, J.‐L.; Béné, Marie Christine; Weber, Max; Fauré, G

doi:10.1016/s0190-9622(08)81737-9

Cited by 13 publications

(10 citation statements)

References 9 publications

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“…33 aCLs often appear to be associated with venous ulcerations of the lower extremities and not with ulcerations due to isolated arteritis. 54 They may trigger the release of platelet activating factor by the endothelial cells, and may initiate platelet aggregation and activation thus favoring the formation of microthrombi.…”

Section: Dermatologic Findingsmentioning

confidence: 99%

Dermatologic aspects of antiphospholipid syndrome

Gantcheva

1998

Int J Dermatology

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Section: Dermatologic Findingsmentioning

confidence: 99%

Dermatologic aspects of antiphospholipid syndrome

Gantcheva

1998

Int J Dermatology

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“…There have been numerous reports documenting the cutaneous changes in APS. Common cutaneous manifestations include livedo reticularis (racemosa), 9 –11 thrombophlebitis 12 and cutaneous ulcers, gangrene or necrosis 13 –18 . Alegre et al 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Common cutaneous manifestations include livedo reticularis (racemosa), [9][10][11] thrombophlebitis 12 and cutaneous ulcers, gangrene or necrosis. [13][14][15][16][17][18] Alegre et al 12 presumed to be associated with lupus anticoagulant. The most frequent cutaneous manifestation was spontaneous thrombophlebitis syndrome (34%), followed by skin ulcer (30%), gangrene (19%), haemorrhage (14%) and cutaneous necrosis (3%).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous papules and nodules in the diagnosis of the antiphospholipid syndrome

et al. 1999

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Of 11 patients with primary or secondary antiphospholipid syndrome (APS), four exhibited papules or nodules on the finger, sole or leg as the initial cutaneous manifestation. Histological examination demonstrated thrombosed vessels or vessels containing organized thrombi in the dermis or in the subcutaneous fat tissue. Cutaneous papules and nodules should be recognized as skin manifestations of APS. Screening tests for antiphospholipid antibodies and lupus anticoagulant are required in patients with cutaneous papules or nodules of unknown aetiology. In cases of positive antiphospholipid antibodies and/or lupus anticoagulant, histological examination is critical in the establishment of the diagnosis of APS.

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“…Several factors causing clotting abnormalities, e.g. protein C, S and AT III deficiency, factor V mutation, prothrombin mutation and anticardiolipin antibody (ACA), have been reported to be associated with cutaneous ulcerations of the leg 2–8 . To our knowledge, lupus anticoagulant, which, like ACA, belongs to the group of antiphospholipid antibodies, has not been previously reported in leg ulcer patients.…”

mentioning

confidence: 93%

“…Thus, it appears that additional factors are involved in the pathogenesis of this condition. Recent reports have suggested that hypercoagulation states may be an important risk factor for leg ulceration 2–7 . Several factors causing clotting abnormalities, e.g.…”

mentioning

confidence: 99%