Antichlamydial and Antisperm Antibodies in Patients with Chlamydial Infections

Dimitrova, D.; Kalaydjiev, S.; Hristov, L.; Nikolov, K; Boyadjiev, T. L.; Nakov, L

doi:10.1111/j.1600-0897.2004.00230.x

Cited by 27 publications

(8 citation statements)

References 31 publications

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“…Opinions about the relevance of ASA in semen, as measured by the mixed antiglobulin reaction (MAR) and immunobead tests in urogenital tract infections are divided. There are reports demonstrating a significantly higher ASA incidence in seminal plasma from patients with prostatitis and epididymitis, as compared with noninflammatory group [130,131]. In contrast to these studies, others suggested the lack of correlation between the presence of ASA and inflammation/infection in semen [132].…”

Section: Role Of the Immune/autoimmune Reactionsmentioning

confidence: 60%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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The invasion of the male reproductive tract by microorganisms, and its subsequent consequences for sperm fertilizing potential, has been intensely discussed. The role of the bacteria that are responsible for the colonization and contamination of the male urogenital tract, rather than its infection, in diminished sperm parameters raises the most controversy. There are numerous premises suggesting that bacterial semen infection is associated with male infertility. However, the molecular mechanism by which the fertility is affected is complex and multifactorial, and still presents a puzzle. Some authors have suggested that direct interactions between bacteria and human spermatozoa facilitate sperm immobilization, affect sperm morphology, and thus weaken the ability of sperm to fertilize. On the other hand, the massive infiltration of activated leukocytes into the inflammatory site may be associated with impairment of sperm fertilizing potential, due to oxidative, apoptotic, and immune processes. This review presents current research trends and aims to summarize the present knowledge of semen inflammation and causative bacterial agents in the male urogenital tract, with its consequence on seminological parameters, and male fertility status.

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Section: Role Of the Immune/autoimmune Reactionsmentioning

confidence: 60%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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“…Among the risk factors for ASA production, the chronic inflammatory diseases with different localization are believed to play an important role [5][6][7][8]. The inflammatory response is associated with production of antibodies to spermatozoal and microbial antigens.…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Dimitrova-Dikanarova

Lazarov

Tafradjiiska-Hadjiolova

et al. 2016

Biotechnology & Biotechnological Equipment

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The aim of this study was to investigate the possible association between serum anti-Helicobacter pylori antibodies and anti-sperm antibodies (ASA) in patients with gastroduodenal diseases caused by H. pylori, infertile patients positive for ASA and healthy fertile blood donors as controls. Serum ASA were studied by sperm agglutination tests, sperm immobilization test and ELISA against sperm antigens (ELISAsp). Serum IgG anti-H. pylori antibodies were detected by ELISA (ELISAHp). The tests revealed significantly higher incidence of ASA in patients with gastroduodenal diseases compared to the controls (P < 0.0001). The median levels of both types of antibodies were significantly higher in infertile patients than in patients with upper gastroduodenal diseases in all tests applied (sperm agglutination and immobilization tests P < 0.0001; ELISAsp P D 0.006; ELISAHp, P D 0.0008). Significant linear correlation was found between anti-H. pylori antibodies and ASA detected by sperm immobilization test (r D 0.613, P D 0.05) in the group of patients with gastroduodenal disease, as well as a weak linear correlation was established between anti-H. pylori antibodies and ASA in ELISAsp (r D 0.275, P D 0.0051) in the same group. These results suggest that H. pylori infection may play a role in the induction of ASA.

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“…There are some reports suggesting that human sperm have antigens that cross‐react immunologically with certain microbial antigens, such as those of C. trachomatis 9–12 . However, this is still controversial.…”

Section: Discussionmentioning

confidence: 99%

“…This is the first demonstration that Ct infection could play a role in the production of sperm‐immobilizing antibodies in infertile women. Dimitrova et al 12 . previously described that the genital C. trachomatis infection might play a role in the induction of antisperm antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…It was also found that genital tract infections, including cervicitis caused by Chlamydia trachomatis , might lead to immunopotentiation of antisperm antibodies that could affect fertility 11 . Recently, it was shown that infertile couples with genital C. trachomatis infection had higher incidences of antisperm antibodies 12 . These reports suggest that C. trachomatis infection might play a role in the induction of antisperm antibodies in women; however, the association between C. trachomatis infection and the production of sperm‐immobilizing antibodies, especially those assessed by quantitative‐SIT, 13,14 has not yet been clearly understood.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of Sperm-immobilizing Antibodies in Infertile Women with Past Chlamydia trachomatis Infection

Hirano

Shibahara

Koriyama

et al. 2011

American Journal of Reproductive Immunology

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Antichlamydial and Antisperm Antibodies in Patients with Chlamydial Infections

Abstract: The genital Chlamydia infection may play a role in the induction of ASA. This is probably a result of the inflammatory process, but not of cross-reactivity between sperm and Chlamydia trachomatis antigens.

Cited by 27 publications

References 31 publications

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Incidence of Sperm-immobilizing Antibodies in Infertile Women with Past Chlamydia trachomatis Infection

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