Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

Eilertsen, Karl‐Erik; Larsen, Roger B.; Mæhre, Hanne K; Jensen, Ida‐Johanne; Elvevoll, Edel O.

doi:10.5772/47865

Cited by 3 publications

(2 citation statements)

References 113 publications

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“…The oldest and best-documented function of taurine is its conjugation with bile acids in bile salt synthesis [80]. The hypolipidemic effect of taurine is partly due to the inhibition of cholesterol absorption in the intestine [81]. It also works by increasing the conversion of cholesterol to bile acid by enhancing 7-α hydroxylase, the rate-limiting enzyme of hepatic cholesterol catabolism, and conjoining with bile acids, this is indicated by enhanced mRNA expression and enzymatic activity of 7a-hydroxylase [82].…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Abdel-Reheim

2016

Int J Pharm Pharm Sci

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Objective: The present study aimed to evaluate the effect of pre-treatment with taurine on rats in which MI had been induced using isoproterenol (ISO).Methods: Rats were randomly allocated into three groups; the 1st group is the normal control (C) one, the 2nd is the isoproterenol cardiotoxic (ISO) one and the 3rd group is the taurine pretreated (T-ISO) one. Results:The activities of the cardiac biomarker enzymes, AST, LDH, CK and CK-MB were elevated in the ISO-treated group. The membrane-bound Na + -K + and Ca 2+ ATPase enzyme activities were decreased in the ISO-treated group. The lipid profile either in sera or cardiac tissues was increased in ISO-treated rats except for HDL-cholesterol and phospholipids. The cholesterol ester synthetase (CES) activity was elevated, while lecithin: Cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) activities were decreased in the myocardial infarcted rats. In addition, the high level of the troponins I and T was an indication of cardiac necrosis. Pre-treatment with Taurine, however, ameliorated all of these changes, in addition to its effect in improving the oxidation process, as measured by lipid peroxidation and the antioxidant enzymes, superoxide dismutase and peroxidase enzymes. Conclusion:Taurine showed amelioration effects on the changes in lipid profile, oxidative stress and myocardial infarction biomarkers and therefore, can be protected against cardiotoxicity.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Abdel-Reheim

2016

Int J Pharm Pharm Sci

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“…Taurine is indispensable during growth and can be found in pure milk, eggs, meat, and fish, as well as food or beverage supplement products. Taurine is formed by the body in the liver followed by the oxidation reaction of the amino acid decarboxylation 7 .…”

Section: Taurinementioning

confidence: 99%

Comparison Study Between HPLC and Uhplc Methods for Testing the Level of Amino Acid

Kurniawansyah¹,

Paramita²,

Prasaja³

2018

Int. Res. J. Pharm.

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Fitamino product from PT. Novell Pharmaceutical is a product formulated in powder form. This product contains a variety of vitamins and amino acids that aim to meet the nutritional needs of consumers for 12 h. Amino acids contained in the product are Branched Chain Amino Acid (BCAA) consisting of isoleucine, leucine, valine and taurine. In this study, the measurement of amino acid levels was done using different instruments. The instruments used were HPLC (High Performance Liquid Chromatography) and UHPLC (Ultra High Performance Liquid Chromatography). The research was done on preparation stage of test sample and test of sample rate using HPLC and UHPLC. The difference between these two methods lied in the derivatisation process. In HPLC, derivatization process was done manually while in UHPLC derivatization, process was done automatically in UHPLC machine. The results of the test showed that the amino acid content tested by HPLC method was greater than the amino acid level tested by UHPLC method that were: taurin 102.2%; valine 102.6%; isoleucine 95.72%; and leucine 101.79% while in UHPLC method: taurine 79.164%; valine 67.763; isoleucine 67.569%; and leucine 72.107%. The results on this UHPLC method were well below the 85-115% requirement. That was because there were different treatments during the test sample preparation process but the time required for the process to use UHPLC was faster than the HPLC method.

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Recent insights into the molecular regulators and mechanisms of taurine to modulate lipid metabolism: a review

Martin

2022

Critical Reviews in Food Science and Nutrition

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Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

Cited by 3 publications

References 113 publications

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Comparison Study Between HPLC and Uhplc Methods for Testing the Level of Amino Acid

Recent insights into the molecular regulators and mechanisms of taurine to modulate lipid metabolism: a review

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