Anticholinergic and antioxidant activities of avocado (<i>Folium perseae</i>) leaves – phytochemical content by LC-MS/MS analysis

Köse, Leyla Polat; Bingöl, Zeynebe; Kaya, Rüya; Gören, Ahmet; Akıncıoğlu, Hülya; Durmaz, Lokman; Köksal, Ekrem; Alwasel, Saleh; Gülçın, İlhami

doi:10.1080/10942912.2020.1761829

Cited by 48 publications

(43 citation statements)

References 89 publications

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“…The FRAP method is a simple, cheap, and fast method that is used to determine the antioxidant capacity of many phenolic, flavonoid, and similar molecules under in vitro conditions. [ 37,56–58 ] Using this method, we analyzed the reduction of Fe 3+ by naphthol‐derived molecules. Fe 2+ in a reduced form gives absorbance at 593 nm by forming a colored complex with TPTZ.…”

Section: Resultsmentioning

confidence: 99%

“…As with DPPH• radical scavenging activity, the ABTS •+ radical scavenging activity method is widely used in pure substances, extracts, and beverages. [ 37,57,58 ] In this method, ABTS •+ cation radical must be created first. The method is based on the direct formation of the blue‐green colored ABTS •+ solution from the interaction of ABTS and K 2 S 2 O 8 and the measurement of this cation radical spectrophotometrically.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and biological evaluation of some 1‐naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors

Erdoğan

Köse

Eşsiz

et al. 2021

Archiv der Pharmazie

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A series of some naphthol derivatives 4a–f, 5a,f, 6a, and 7a,b (six novel ones: 4c,d, 5a, 6a, 7a,b) bearing F, Cl, Br, OMe, and dioxole substituents at different positions of the aromatic rings was designed, synthesized, and characterized. The naphthol derivatives were synthesized in three steps, namely the addition reaction of furan via Diels–Alder cycloaddition reaction, copper(II) trifluoromethanesulfonate (Cu(OTf)2)‐catalyzed aromatization reaction, and the bromination reaction, respectively. The structures of the newly obtained compounds (4c,d, 5a, 6a, 7a,b) were characterized by spectroscopic techniques. In addition, some biological activity studies were investigated under in vitro conditions. Inhibition studies of these compounds were performed on human carbonic anhydrase (hCA) I and II isoenzymes purified from human erythrocytes as a biological evaluation. Moreover, their potential antioxidant and antiradical activities were studied by analytical methods like ABTS•+ and DPPH• scavenging, and it was determined that some molecules showed good activity. Also, inhibition of acetylcholinesterase (AChE), which is a marker of many degenerative neurological diseases, was tested and the results were discussed. Excellent enzyme inhibition results were recorded for most of the molecules. These 1‐naphthol derivatives were found as effective inhibitors for hCA I, hCA II, and AChE with K i values ranging from 0.034 ± 0.54 to 0.724 ± 0.18 µM for hCA I, 0.172 ± 0.02 to 0.562 ± 0.21 µM for hCA II, and 0.096 ± 0.01 to 0.177 ± 0.02 µM for AChE.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Synthesis and biological evaluation of some 1‐naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors

Erdoğan

Köse

Eşsiz

et al. 2021

Archiv der Pharmazie

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“…Cu 2+ -reducing ability of EEFO and WEFO and standards at the same concentration (30 μg/mL) demonstrated the following order: BHT (λ700: 1.561±0.089, r 2 : 0.9978) >ascorbic acid (λ700: 1.069±0.007, r 2 : 0.9722) > α-tocopherol (λ700: 0.785±0.061, r 2 : 0.9986) > EEFO (λ700: 0.954±0.017, r 2 : 0.9928) and WEFO (λ700: 0.236± 0.020, r 2 : 0.9998). The iron-chelating ability is very significant due to ionic species like ferrous ion (Fe 2+ ) facilitating the production of free ROS in the organism [67]. This binding assay is a significant antioxidant method used for prevention or delaying of oxidation processes catalyzed by metal ions, however excessive metal ions can cause cell damage.…”

Section: Resultsmentioning

confidence: 99%

Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Kızıltaş¹,

Gören²,

Bingöl³

et al. 2021

Rec.Nat.Prod.

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To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS•+ scavenging activity, DPPH· scavenging activity, Fe3+reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, α-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 µg/mL against acetylcholinesterase (AChE), 0.815 µg/mL against α-glycosidase, and 0.675 µg/mL against α-amylase.

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“…With all this, it is well established that polyphenols also have anti-AD properties and α-glycosidase inhibition profiles. Therefore, one of the most important therapy approaches for neurodegenerative diseases and DM is natural compounds and products including phenolic compounds [28,29,30,31]. However, current evidence demonstrates that patients with DM have an increased risk of developing AD.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

Bingöl

Kızıltaş

Gören

et al. 2021

Heliyon

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In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract (WESB) of Shaggy bindweed (Convulvulus betonicifolia Mill. Subs), some putative antioxidant methods such as DPPH⋅ scavenging activity, ABTS þ scavenging effect, ferric ions (Fe 3þ ) reduction method, cupric ions (Cu 2þ ) reducing capacity, and ferrous ions (Fe 2þ ) binding activities were separately performed. Also, ascorbic acid, α-tocopherol and BHT were used as the standard compounds. Additionally, some phenolic compounds that responsible for antioxidant abilities of EESB and WESB were screened by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At the same concentration, EESB and WESB demonstrated effective antioxidant abilities when compared to standards. In addition, EESB demonstrated IC 50 values of 1.946 μg/mL against acetylcholinesterase (AChE), 0.815 μg/mL against α-glycosidase and 0.675 μg/mL against α-amylase enzymes.

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Anticholinergic and antioxidant activities of avocado (Folium perseae) leaves – phytochemical content by LC-MS/MS analysis

Cited by 48 publications

References 89 publications

Synthesis and biological evaluation of some 1‐naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors

Synthesis and biological evaluation of some 1‐naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors

Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

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