Anticholinesterase activity of endemic plant extracts from Soqotra

Bakthir, Hussein; Ali, Nasser A. Awadh; Arnold, Norbert; Teichert, Axel; Wessjohann, Ludger A.

doi:10.4314/ajtcam.v8i3.65292

Cited by 18 publications

(21 citation statements)

References 10 publications

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“…B. socotrana essential oil showed the higher AChE inhibitory activity at 59.3% at a concentration of 200 lg/mL in comparison to the essential oils of B. elongata and B. ameero (29.6% and 41.6% enzyme inhibition, respectively). It has been shown that at 200 mg/L, chloroform extracts of B. socotranus and B. elongata (Bakthira et al 2011) inhibited AChE by 71.2% and 46.3%, respectively, but methanol extracts showed an inhibitory activity below 50%. Our essential oil was more active than those mentioned above (IC 50 ¼ 67.10 ± 0.03 mg/L).…”

Section: Biological Activitiesmentioning

confidence: 99%

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves

Kohoude

Gbaguidi

Agbani

et al. 2016

Pharmaceutical Biology

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Context: Boswellia dalzielii Hutch. (Burseraceae) is an aromatic plant. The leaves are used for beverage flavouring.Objective: This study investigates the chemical composition and biological activities of various extracts. Materials and methods: The essential oil was prepared via hydrodistillation. Identification and quantification were realized via GC-MS and GC-FID. Consecutive extractions (cyclohexane, dichloromethane, ethyl acetate and methanol) were carried out and various chemical groups (phenolics, flavonoids, tannins, antocyanins and sugar) were quantified. The volatile compounds of organic extracts were identified before and after derivatization. Antioxidant, antihyperuricemia, anti-Alzheimer, anti-inflammatory and anticancer activities were evaluated. Results: In the essential oil, 50 compounds were identified, including 3-carene (27.72%) and a-pinene (15.18%). 2,5-Dihydroxy acetophenone and b-D-xylopyranose were identified in the methanol extract. Higher phenolic (315.97 g GAE/kg dry mass) and flavonoid (37.19 g QE/kg dry mass) contents were observed in the methanol extract. The methanol extract has presented remarkable IC 50 ¼ 6.10 mg/L for antiDPPH, 35.10 mg/L for antixanthine oxidase and 28.01 mg/L for anti-5-lipoxygenase. For acetylcholinesterase inhibition, the best IC 50 (76.20 and 67.10 mg/L) were observed, respectively, with an ethyl acetate extract and the essential oil. At 50 mg/L, the dichloromethane extract inhibited OVCAR-3 cell lines by 65.10%, while cyclohexane extract inhibited IGROV-1 cell lines by 92.60%. Discussion and conclusion: Biological activities were fully correlated with the chemical groups of the extracts. The ethyl acetate and methanol extracts could be considered as potential alternatives for use in dietary supplements for the prevention or treatment of diseases because of these extracts natural antioxidant, antihyperuricemic and anti-inflammatory activities.ARTICLE HISTORY

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Section: Biological Activitiesmentioning

confidence: 99%

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves

Kohoude

Gbaguidi

Agbani

et al. 2016

Pharmaceutical Biology

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“…An inhibitory activity has been reported for green leaves of C. sinensis previously [29]. The occurrence of flavonoid saponins, polyphenols, and catechins is well documented in different preparations of C. sinensis .…”

Section: Resultsmentioning

confidence: 85%

“…The finding of this study shows that the four most active herbal extracts contained not only nitorgenic compound such as alkaloid but also these extracts also contain rich components of saponin, flavonoid, and essential oils [29-34]. The new area of interest in research involves both AChE inhibitors and BuChE inhibitors after recognition of BuChE activity in hippocampus of patients with AD [33,42,43].…”

Section: Resultsmentioning

confidence: 99%

A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine

et al. 2014

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BackgroundThe aim of this study was to evaluate acetylcholinesterase inhibitory activity of some commonly used herbal medicine in Iran to introduce a new source for management of Alzheimer’s disease. A total of 18 aqueous-methanolic extract (1:1; v/v) from the following plants: Brassica alba, Brassica nigra, Camellia sinensis, Cinchona officinalis, Citrus aurantifolia, Citrus x aurantium, Ferula assafoetida, Humulus lupulus, Juglans regia, Juniperus sabina, Myristica fragrans, Pelargonium graveolens, Pistacia vera, Punica granatum, Rheum officinale, Rosa damascena, Salix alba, and Zizyphus vulgaris were prepared and screened for their acetylcholinesterase inhibitory activity using in vitro Ellman spectrophotometric method.ResultsAccording to the obtained results, the order of inhibitory activity (IC50 values, μg /ml) of extracts from highest to the lowest was: C. sinensis (5.96), C. aurantifolia (19.57), Z. vulgaris (24.37), B. nigra (84.30) and R. damascena (93.1).ConclusionsThe results indicated and confirmed the traditional use of these herbs for management of central nervous system disorders. C. sinensis showed the highest activity in inhibition of acetylcholinesterase. However, further investigations on identification of active components in the extracts are needed.

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“…[22][23][24] Plant based compounds have been used as cognition enhancers herbs like Withania somnifera, Centella asiatica, Curcuma longa, Bacopa monnieri, Convolvulus pluricaulis, Celastrus paniculatus, Nardostachys jatamansi have been reported to be used in management of cognitive impairment in Ayurvedic system of medicine. 25,26 Acetyl cholinesterase inhibitory activity is dose dependently increasing at a concentration ranging from 50 µg/ml to 300 µg/ml and when compared to standard Galanthamine the inhibitory activity is moderate even though the tested extract shows significant activity. The results are depicted in Table 1 and Figure 1 and can be used for treating neurodegenerative disorders.…”

Section: Resultsmentioning

confidence: 99%

In vitro Acetyl Cholinesterase Inhibitory assay of Acacia catechu Willd Ethanolic Seed Extract

Thangavelu¹,

Ramasamy²

2015

Phcog J

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Aim & objective:The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of Acacia catechu ethanolic seed extract to introduce a new source for management of Alzheimer's disease. Background: Alzheimer's disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50-60% of dementia cases in persons over 65 years of age. It is likely that the inhibition of acetyl cholinesterase by Acacia catechu ethanolic seed extract that is rich in flavonoids and antioxidants may aid in the protection of neurodegenerative disorders and ultimately Alzheimer's disease. Methods: Anti cholinesterase activity is determined by adopting In vitro standard protocol. Results: According to the obtained results, the inhibitory activity (IC 50 values, μg /ml) of extracts was 204.38 ± 2.54 µg/ ml. Conclusion: The results indicated and confirmed the traditional use of Acacia catechu ethanolic seed extract for management of central nervous system disorders. It showed the moderate activity in inhibition of acetyl cholinesterase at various concentrations. However, further investigations on identification of active components in the extracts are needed.

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Anticholinesterase activity of endemic plant extracts from Soqotra

Abstract: Abstract:A total of 30 chloroform and methanol extracts from the following endemic Soqotran

Cited by 18 publications

References 10 publications

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves

Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves

A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine

In vitro Acetyl Cholinesterase Inhibitory assay of Acacia catechu Willd Ethanolic Seed Extract

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