2010
DOI: 10.1186/ar3190
|View full text |Cite
|
Sign up to set email alerts
|

Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferasein a cross-sectional study

Abstract: IntroductionA deletion polymorphism in glutathione S-transferase Mu-1 (GSTM1-null) has previously been implicated to play a role in rheumatoid arthritis (RA) risk and progression, although no prior investigations have examined its associations with anticitrullinated protein antibody (ACPA) positivity. The purpose of this study was to examine the associations of GSTM1-null with ACPA positivity in RA and to assess for evidence of interaction between GSTM1 and HLA-DRB1 shared epitope (SE).MethodsAssociations of G… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
24
1

Year Published

2011
2011
2018
2018

Publication Types

Select...
10

Relationship

5
5

Authors

Journals

citations
Cited by 39 publications
(26 citation statements)
references
References 43 publications
1
24
1
Order By: Relevance
“…In contrast , heavy smokers expressing functional GSTT1 were just 1.4 times as likely to develop seropositive RA. Although we found no evidence of an interaction between GSTM1-null status and smoking, we recently observed significant interactions between the GSTM1-null genotype and SE status in ACPA positivity, underscoring the potential pathogenic role of DMEs and increased oxidative stress in RA [23].…”
Section: Cigarette Smokingcontrasting
confidence: 63%
“…In contrast , heavy smokers expressing functional GSTT1 were just 1.4 times as likely to develop seropositive RA. Although we found no evidence of an interaction between GSTM1-null status and smoking, we recently observed significant interactions between the GSTM1-null genotype and SE status in ACPA positivity, underscoring the potential pathogenic role of DMEs and increased oxidative stress in RA [23].…”
Section: Cigarette Smokingcontrasting
confidence: 63%
“…The association between oxidative stress and anti-CCPs was also validated by a recent study showing that a deletion polymorphism in glutathione S-transferase Mu-1 (antioxidant enzyme) was associated with anti-CCP positivity, 32 suggesting that oxidative stress might be involved in the development of RA-specific autoimmunity in genetically susceptible subjects. Moreover, a recent study showed an increased synovial oxidant activity in anti-CCP-positive RA patients compared with RA patients negative for anti-CCPs.…”
Section: Discussionmentioning
confidence: 76%
“…Rheumatoid factor (positivity ≥ 15 IU/ml) and high sensitivity C-reactive protein (hsCRP, mg/l) were determined by nephelometry (Siemens Healthcare Diagnostics, Munich, Germany). The presence of HLA-DRB1 shared-epitope (SE) containing alleles was determined using banked DNA as described 24 . Additional measures collected at enrollment included tender and swollen joint counts (range 0-28), erythrocyte sedimentation rate (ESR; mm/h), pain (range 0-10), a 10-item multidimensional Health Assessment Questionnaire score (MD-HAQ; range 0-3) 25 , and patient and physician global well-being scores (100-mm visual analog scales).…”
Section: Methodsmentioning
confidence: 99%