Anticlastogenic Effect of Ginkgo Biloba Extract in Graves’ Disease Patients Receiving Radioiodine Therapy

Dardano, Angela; Ballardin, Michela; Ferdeghini, M; Lazzeri, Elisa; Traino, Claudio; Caraccio, N; Mariani, Giuliano; Barale, Roberto; Monzani, Fabio

doi:10.1210/jc.2007-0597

Cited by 39 publications

(18 citation statements)

References 16 publications

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“…This possibility is supported by the genotoxicity associated with radiations which were observed by several studies. Such studies have investigated the level of genome damage and micronucleus in thyroid cancer patients environmentally exposed to radiation after the Chernobyl fallout (Sbrana et al 2006; Tronko et al 2007; Cardis and Hatch 2011), after Fukushema in Japan (Medalia 2011), in patients affected by thyroid cancer who underwent radiotherapy (Livingston et al 1993; Gutierrez et al 1997, 1999; Dardano et al 2007; Hooman et al 2008), and in people affected by thyroid nodules following occupational exposure to ionizing radiation (Brooks et al 2007; Scarpato et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Micronucleus frequency among Iraqi thyroid disorder patients

Al-Faisal

AL-Ramahi²,

Abdul-Hassan

2012

Comp Clin Pathol

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Micronucleus (MN) assay has been extensively used in detection of DNA damage, instability in cancer, and genetic disorders. In the current study, MN, binucleated cells, and nuclear division index (NDI) were investigated in Iraqi patients with thyroid disorders. The results indicated significantly (p < 0.05) increased binucleated cells with micronucleus (BNMN) frequencies in thyroid cancer group (37.58 ± 3.07) versus other thyroid disorder groups (6.60 ± 1.29, 14.90 ± 1.69, 15.56 ± 1.76). On the other hand, the frequency of micronucleus per 1,000 and the NDI were significantly (p < 0.05) decreased in hypothyroidism (MN 1.55 ± 0.36) (NDI 0.009 ± 0.001) versus other thyroid disorder groups (MN: 6.05 ± 0.97, 6.09 ± 0.53, 5.34 ± 0.56) (NDI: 0.049 ± 0.003, 0.032 ± 0.002, 0.025 ± 0.002), with no difference versus healthy group (0.0 ± 0.0). The number of BNMN and MN are parallel to the severity of thyroid disorders which were 6.60 ± 1.29, 14.90 ± 1.69, 15.56 ± 1.76, and 37.58 ± 3.07 for hypothyroidism, thyroid toxic goiter, thyroid nontoxic goiter, and thyroid cancer, respectively. The number of BNMN and MN are parallel to the severity of thyroid disorders which were 6.60 ± 1.29, 14.90 ± 1.69, 15.56 ± 1.76, and 37.58 ± 3.07 for hypothyroidism, thyroid toxic goiter, thyroid nontoxic goiter, and thyroid cancer, respectively. The results also indicate that there were no significant differences among age and sex groups as related with BNMN formation within each thyroid disorder groups and healthy control group.

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Section: Discussionmentioning

confidence: 99%

Micronucleus frequency among Iraqi thyroid disorder patients

Al-Faisal

AL-Ramahi²,

Abdul-Hassan

2012

Comp Clin Pathol

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“…Although many studies analyze the effects of EGb 761 in brain and nervous system, EGb 761 actually possesses multifaceted effects and has different benefits in different organs. For examples, it attenuates testicular injury and intestinal epithelial apoptosis, as well as neutralizes the genotoxic damage induced by radioiodine in patients with Grave's disease (Akgul et al, 2007;Dardano et al, 2007;Liu et al, 2007). However, these studies analyze the effects of EGb 761 in a single organ.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis of EGb 761-regulated neuroactive receptor pathway in vivo

Su¹,

Hsieh²,

Wu³

et al. 2009

Journal of Ethnopharmacology

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“…The anticlastogenic effect of the EGb761 extract was verified by the micronucleus test in patients with hyperthyroidism that underwent radiation therapy with iodine-131. It was found that supplementation reduces the genotoxic damage induced by radiation, without compromising the clinical recovery of the patients (Dardano et al, 2007). Sener et al (2006) analyzed the same radioprotective effect in which the G. biloba extract reduced the oxidative damage induced by ionizing radiation and the level of DNA fragmentation in the ileum of rats supplemented for 15 days before exposure to radiation.…”

Section: Resultsmentioning

confidence: 99%