Anticoagulant Activity of Dayak Onion Bulb (Eleutherine bulbosa) Extract on Human Blood Samples

Abstract

Cardiovascular disease can occur due to disruption of the hemostatic system by forming blood clots in blood vessels, or commonly known as deep vein thrombosis. The curative action that has been carried out in the form of heparin anticoagulant administration had many side effects such as bleeding, hematuria, thrombocytopenia, and hypersensitivity; therefore, alternative anticoagulant ingredients such as onion bulbs have emerged. Dayak onion bulb (Eleutherine bulbosa) is known to contain eleutherinol compound, which has anticoagulant activity. This study aims to determine the potential anticoagulant activity of Dayak onion bulbs extract (Eleutherine bulbosa) on human blood samples. This anticoagulant activity test was carried out by observing the length of time for blood clotting in the extract treatment group with several concentrations (0, 10, 12.5, 16, 25, and 50%) by Clotting Time (Lee-White) method. The results showed a significant delay in blood coagulation time in the group treated with Dayak onion bulbs extract as increasing the concentration. About 50% Dayak onion onion bulb extract was showed a twofold increase in blood coagulation time thanthat of no extract administration. So that, Dayak bulb onion has the opportunity to be an alternative natural anticoagulant.
 Keywords: anticoagulants; Dayak onion bulbs (Eleutherine bulbosa); clotting time

Callogenesis of Dayak Onion (Eleutherine palmifolia) Bulb in response of Picloram, 2,4-D, and Kinetin

“…The main compounds are isoliquiritigenin, transresveratrol, oxyresveratrol, eleuterol, eleuterin, eleuterinol, isoeleuterin, isoeleuterol, eleukanarol, and eleuterinol (Prayitno et al, 2018;Mutiah et al, 2019). Dayak onions have been scientifically proven to have anticancer bioactivity (Mutiah et al, 2019;Mutiah et al, 2020;Wijayanti et al, 2019), antimicrobial (Puspadewi et al, 2013), antioxidant (Arwati et al, 2018), antidiabetic (Ahmad et al, 2018;Dewi et al, 2016;Harahap et al, 2023), antifungal, anti-inflammatory (Arbain et al, 2022) and anticholesterol (Febrinda et al, 2014). The antidiabetic abilities of this plant are thought to be related to inhibiting alphaglucosidase which can lower postprandial blood glucose levels, and the ability to repair pancreatic beta cell damage, thereby increasing insulin secretion directly (Febrinda et al, 2014).…”