Anticoagulant Activity of Sodium Aminodeoxycellulose Sulfates

Abstract

Synopsis The anticoagulant activity of sodium aminopolysaccharide sulfates was tested in vitro by Lee and White method. All of them showed an activity in delaying coagulation of blood. Several sodium aminodeoxycellulose sulfates had higher anticoagulant activity than all of the commercial anticoagulants except for sodium heparinate. Some films prepared by treating sodium aminodeoxycellulose sulfates with formalin or polyvinyl alcohol also had an anticoagulant activity.

Staudinger Reduction Chemistry of Cellulose: Synthesis of Selectively O-Acylated 6-Amino-6-deoxy-cellulose

“…One particular benefit to this approach is that the reactions predominantly occur at primary hydroxyl group sites, providing a mechanism for regioselective derivatization of the polysaccharide . This azide substitution and reduction pathway has been used to synthesize both 6-amino-6-deoxy-chitosan , and 6-amino-6-deoxy-cellulose. − The former compound was found to have in vitro gene carrier properties superior to chitosan, while the latter compound has been studied as a precursor to artificial heparin-like polymers in attempts to mimic that compound’s anticoagulant properties. , 6-Amino-6-deoxy-cellulose is also of interest because it is a structural isomer of fully deacetylated chitosan (Figure ). However, despite this structural similarity, there are apparently no reports as yet of its evaluation for drug or nucleic acid delivery applications.…”

“…27−31 The former compound was found to have in vitro gene carrier properties superior to chitosan, while the latter compound has been studied as a precursor to artificial heparinlike polymers in attempts to mimic that compound's anticoagulant properties. 32,33 6-Amino-6-deoxy-cellulose is also of interest because it is a structural isomer of fully deacetylated chitosan (Figure 1). However, despite this structural similarity, there are apparently no reports as yet of its evaluation for drug or nucleic acid delivery applications.…”

Deoxycelluloses and related structures

“…Deoxycelluloses were used as anticoagulants and blood dialysis membranes; examples include aminodeoxycellulose sulfates [66] and various deoxythiocarboxyaryl derivatives [67]. Urokinase was purified with the zinc salt of amindeoxycellulose derivatives [68]. The 2-aminodeoxycelluloses were patented for their use in treatment of neurological disorders [69] and chronic inflammatory diseases such as colitis and arthritis [70].…”

Deoxycelluloses and related structures

“…Urokinase was purified with the zinc salt of amindeoxycellulose derivatives [68]. The 2-aminodeoxycelluloses were patented for their use in treatment of neurological disorders [69] and chronic inflammatory diseases such as colitis and arthritis [70].…”