Anticoagulant and antiplatelet properties of the latex of unripe fruits of Carica papaya L. (Caricaceae)

Asare, Frederick; Koffuor, George Asumeng; Nyansah, Wilson Bright; Gyanfosu, Linda; Abruquah, Akua Afriyie

doi:10.18203/2319-2003.ijbcp20151355

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Results of Osoniyi and Onajobi [ 42 ] indicated that the procoagulant and anticoagulant activities were coordinated with J. curcas latex via PT and APPT assays. The current study exhibited findings that disagree with other studies [ 43 , 44 ], which reported the anticoagulant activities of Carica papaya and J. gossypiifolia latex. Khuraishi et al [ 45 ] assessed the anticoagulant potential of latex collected from plants involving T. peruviana , Euphorbia milii , E. pulcherimma , Artocarpus altilis , and J. malacophylla , and recorded the highest anticoagulant activity in last two plants only.…”

Section: Resultscontrasting

confidence: 99%

Anticancer, Anticoagulant, Antioxidant and Antimicrobial Activities of Thevetia peruviana Latex with Molecular Docking of Antimicrobial and Anticancer Activities

et al. 2022

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Natural origin molecules represent reliable and excellent sources to overcome some medicinal problems. The study of anticancer, anticoagulant, and antimicrobial activities of Thevetia peruviana latex were the aim of the current research. An investigation using high-performance liquid chromatography (HPLC) revealed that the major content of the flavonoids are rutin (11.45 µg/mL), quersestin (7.15 µg/mL), naringin (5.25 µg/mL), and hisperdin (6.07 µg/mL), while phenolic had chlorogenic (12.39 µg/mL), syringenic (7.45 µg/mL), and ferulic (5.07 µg/mL) acids in latex of T. peruviana. Via 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical scavenging, the experiment demonstrated that latex had a potent antioxidant activity with the IC50 43.9 µg/mL for scavenging DPPH. Hemolysis inhibition was 58.5% at 1000 µg/mL of latex compared with 91.0% at 200 µg/mL of indomethacin as positive control. Negligible anticoagulant properties of latex were reported where the recorded time was 11.9 s of prothrombin time (PT) and 29.2 s of the activated partial thromboplastin time (APTT) at 25 µg/mL, compared with the same concentration of heparin (PT 94.6 s and APPT 117.7 s). The anticancer potential of latex was recorded against PC-3 (97.11% toxicity) and MCF-7 (96.23% toxicity) at 1000 μg/mL with IC50 48.26 μg/mL and 40.31 µg/mL, respectively. Disc diffusion assessment for antimicrobial activity recorded that the most sensitive tested microorganisms to latex were Bacillus subtilis followed by Escherichia coli, with an inhibition zone (IZ) of 31 mm with minimum inhibitory concentration (MIC) (10.2 μg/mL) and 30 mm (MIC, 12.51 μg/mL), respectively. Moreover, Candida albicans was sensitive (IZ, 28 mm) to latex, unlike black fungus (Mucor circinelloides). TEM examination exhibited ultrastructure changes in cell walls and cell membranes of Staphylococcus aureus and Pseudomonas aeruginosa treated with latex. Energy scores of the molecular docking of chlorogenic acid with E. coli DNA (7C7N), and Rutin with human prostate-specific antigen (3QUM) and breast cancer-associated protein (1JNX), result in excellent harmony with the experimental results. The outcome of research recommended that the latex is rich in constituents and considered a promising source that contributes to fighting cancer and pathogenic microorganisms.

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Section: Resultscontrasting

confidence: 99%

Anticancer, Anticoagulant, Antioxidant and Antimicrobial Activities of Thevetia peruviana Latex with Molecular Docking of Antimicrobial and Anticancer Activities

et al. 2022

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“…[62] CODEN (USA): AJPRHS of a platelet plug (platelet activation and aggregation), conversion of serine proteases (zymogens) to active forms, active forms of clotting factors (such as Xa and thrombin), the release of calcium from the cytosol or increase in natural anticoagulant effects such as fibrinolysis inhibitors that can activate thrombin, AT III, and protein C. The results show that the sap from the unripe fruit of C. papaya L. has anticoagulant and antiplatelet properties which are useful as adjunctive therapy in the treatment of blood clotting disorders (33) .…”

Section: Carica Papaya Lmentioning

confidence: 97%

Review: Phytochemical of Some Plants with Anticoagulant

Sitiawani¹,

Azizah²,

Asra³

et al. 2022

Asian J Pharm Res Dev

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Background: Anticoagulants are drugs used to treat hypertension and cardiovascular disease.This review article aims to discuss several types of natural plants with anticoagulant activity. Materials and Methods: The method used is the study of relevant literature(national and international journals) which is accessed through online sites such as Google Scholar, Research Gate, Science Direct, Springer Link, and NCBI, published in the last 10 years (2011-2021) with the keyword “herbal plant” or “medicinal plant” and “anticoagulant” and “cardiovascular”. Results: Based on in vitro and in vivo tests, some plants such as Allium sativum L., Averrhoa bilimbi, Persea americana Mill., Tridax procumbens L., Carica papaya L., Rhizophora sp, Syzygiumcumini L., Piper batle L., Erigeron canadensis L., Ainsliaea fragrans, Averrhoa bilimbi, Carica papaya L., are types of plants with anticoagulant activity. Conclusion: Herb can be used as alternative sources of new anticoagulant agents cause of their biological activity. The use of medicinal plants with therapeutic effects and minimal side effects can be the best choice for the prevention and treatment of various diseases including cardiovascular disorders.

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“…30,31 Anticoagulant activity Researchers utilized PT time and powered incomplete thromboplastin time assays to assess the cell viability anticoagulation action of PT mucilage, and it was discovered that it possesses effective anticoagulant properties. [32][33][34][35] Antifungal activity T. peruviana seedlings were examined for antifungal photoactivity. Thin-layer chromatography was employed for further examination, and column chromatography has been used to separate decoction prepared using dichloromethane or n-hexane.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Thevetia peruviana: Its Phytochemistry, Traditional and Medicinal Uses, and Pharmacological Activities

Chauhan,

Mazumder,

Chandel

2023

IJDDT

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Thevetia peruviana, a member of the Apocynaceae family, is also known as digoxin, fortunate nut, yellow oleander, and other names. After consumption, T. peruviana plants have the potential to be fatal. In South Asian countries, especially in Sri Lanka and India, T. peruviana is frequently used for international self-harm. Around the world’s tropical and subtropical regions, T. peruviana is a common cause of toxicological emergencies. The entire plant is hazardous due to the presence of several cardiac glycosides, including neriifolin, oleandrin, thevetin A, and thevetin B. Oleander consumption causes hyperkalemia, vomiting, diarrhea, abdominal pain, and all of the above. In the majority of cases, supportive care and the administration of activated charcoal are used in the clinical therapy of either N. oleander or T. peruviana poisoning. T. peruviana-related information is compiled in this article.

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Anticoagulant and antiplatelet properties of the latex of unripe fruits of Carica papaya L. (Caricaceae)

Cited by 6 publications

References 19 publications

Anticancer, Anticoagulant, Antioxidant and Antimicrobial Activities of Thevetia peruviana Latex with Molecular Docking of Antimicrobial and Anticancer Activities

Anticancer, Anticoagulant, Antioxidant and Antimicrobial Activities of Thevetia peruviana Latex with Molecular Docking of Antimicrobial and Anticancer Activities

Review: Phytochemical of Some Plants with Anticoagulant

Thevetia peruviana: Its Phytochemistry, Traditional and Medicinal Uses, and Pharmacological Activities

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