Anticoagulant and antithrombotic effects of chemically sulfated fucogalactan and citrus pectin

Román, Yony; Barddal, Helyn Priscila de Oliveira; Iacomini, Marcello; Sassaki, Guilherme L.; Cipriani, Thales R.

doi:10.1016/j.carbpol.2017.06.110

Cited by 22 publications

(3 citation statements)

References 35 publications

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“…LM pectin has been beneficially used for the healing of impaired wounds. It has a strong anti‐inflammatory effect originating from the esterified galacturonic acid residues, antimicrobial nature related to the presence of carboxylic acid groups, and antithrombogenic properties owing to sulfated fractions . However, LM pectin films have poor mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Low‐methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Kocaaga

Kürkçüoğlu

Tatlıer

et al. 2019

J of Applied Polymer Sci

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This study presents the design of novel hydrogel films, based on low-methoxyl (LM) pectin and NaA-or ZnA-zeolite particles, to serve as wound dressing materials with controlled drug delivery properties. We studied the effects of the preparation method of hydrogels, the amounts of crosslinker, drug and zeolite, and the type of cation in zeolites on the drug release mechanisms from the hydrogels. Ionic strengths of both film and external medium dictated the drug release behavior of the films, while the other parameters also played essential roles. NaAzeolite hydrogels prepared using membrane diffusion controlled system, could reach a drug release ratio of 86% within 5 h. The drug-free hydrogels displayed no cytotoxicity while supporting cell proliferation and migration. Our cost-effective LM pectin-zeolite hydrogels promise to be effective wound dressing materials with controlled drug delivery ability, transparency, good swelling properties, ability to hold fluids, good oxygen transmission rate, and biocompatibility.Pectin is a water soluble polysaccharide mostly extracted from citrus peels. It is a byproduct or waste product of fruit juice industry; therefore, it is easily available and cheap. It is mainly composed of linear chains of galacturonic acid residues. Pectin is referred to as low-methoxyl pectin (LM-pectin) in case the degree of esterification of the carboxylic acid groups is <50%. LM pectin forms three-dimensional (3D) network gels of Ca 2+ ion-bridged dimers to induce an "egg box shell" structure, 4 which makes it an Additional Supporting Information may be found in the online version of this article.

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Section: Introductionmentioning

confidence: 99%

Low‐methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Kocaaga

Kürkçüoğlu

Tatlıer

et al. 2019

J of Applied Polymer Sci

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“…Thrombosis is the formation of blood clots (thrombus) in the circulatory system caused by the imbalance of homeostatic system. The majority of cardiovascular diseases, including acute coronary syndrome, venous thromboembolism, deep vein thrombosis, pulmonary embolism, myocardial infarction, atherosclerosis, and ischemic stroke, are associated with thrombotic disorders, resulting in serious consequences such as sudden death [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Juglans regia Root Bark Extract on Platelet Aggregation, Bleeding Time, and Plasmatic Coagulation: In Vitro and Ex Vivo Experiments

Amirou

Bnouham

Legssyer

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Platelets have an important role in thrombosis and haemostasis. Hyperactivity of the platelets has been associated with thromboembolic diseases and represents the main cause of complications of cardiovascular diseases. Crude aqueous extract (CAE) of Juglans regia root bark was evaluated for bleeding time, antiaggregant activity by using agonists, thrombin, ADP, collagen, or arachidonic acid (in vitro and ex vivo), and anticoagulant activity by measuring the clotting parameters: activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen dosage (in vitro and ex vivo). The result of this study reported that the strongest antiaggregant effect of CAE in vitro was observed on the ADP-induced aggregation with inhibitions up to 90 %, while, in ex vivo experiments, the inhibition (more than 80 %) was observed with all agonists. Anticoagulant effect of CAE significantly prolonged the TT and decreased the fibrinogen level in vitro and ex vivo without interfering with APTT and PT. The bleeding time in mice and rats was significantly increased by CAE. The antiplatelet and anticoagulant effect observed in this study suggest that Juglans regia could have antithrombotic and/or thrombolytic activities and provide an alternative therapy against thrombotic complications related to cardiovascular diseases.

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“…Pectin, a natural polysaccharide found in citrus fruits as well as in most of the ripened fruits shows antithrombic activity. 6 The pectin is widely used as a pharmaceutical excipient and its role as solid dispersion carrier was so far has been studied and was found to be suitable for the formulation of solid dispersions of aceclofenac and resulted in enhanced solubility of the selected drug. 7 Thus, in this research work, it is hypothesized that solid dispersions containing pectin as the carrier of clopidogrel will result in better bioavailability, faster onset of action and possible dose reduction.…”

Section: Introductionmentioning

confidence: 99%

Development of Solid Dispersions of Clopidogrel using Innate Excipient: Synergistic Antiplatelet Activity

SinghVerma¹,

Verma²,

Ashawat³

et al. 2020

IJPER

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Anticoagulant and antithrombotic effects of chemically sulfated fucogalactan and citrus pectin

Cited by 22 publications

References 35 publications

Low‐methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Low‐methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Effects of Juglans regia Root Bark Extract on Platelet Aggregation, Bleeding Time, and Plasmatic Coagulation: In Vitro and Ex Vivo Experiments

Development of Solid Dispersions of Clopidogrel using Innate Excipient: Synergistic Antiplatelet Activity

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